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(acetoxyphenyl)indene deriv. binding by (diethylcyclopropanediyl)bis(phenyl) diacetates for treatment of human) ethylcyclopropanediylbisphenyl diacetate antitumor stilbene analog mammary carcinoma estrogen receptor stilbene analog (dimethylphenylalanyl)ephedrine stereoisomers inhibition of elec. activity of) nerve sodium cond ephedrine deriv anesthetic nerve sodium cond (hydroxyphenyl)(trifluoropropyl)hydroxybenzamides as) hydroxyphenylbenzamide prepn antiestrogenic antitumor uterus hydroxyphenylbenzamide prepn -epoxyhexene 1-(2 1-dicarboxylato]platinum(II) 2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Amines Role: BAC (Biological activity or effector 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Antitumor agents (prepn. and stereoselectivity in antitumor activity of [1 2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) platinum diaminophenylpropane chloro prepn antitumor activity stereoselectivity antitumor activity platinum diaminophenylpropane chloro phenylpropanediamine platinum chloro prepn antitumor activity diamine platinum chloro prepn antitumor activity conformation platinum diaminophenylpropane chloro isomer 2-diphenylethylenediamine 2-diphenylethylenediamine diastereomers) Ethylenediamine Role: PREP (Preparation) 2-methylene steroids) Molecular structure-biological activity relationships (anesthetic 3-dibutyl-4 5-diphenylimidazolidine) Conformation Spectra 6-dic Structure-activity relationship (antitumor [Aqua-1-(2 6-Dichloro-4-hydroxyphenyl)-2-phenylethanes 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector 6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm 6-xylidides) aminoacyl aniline anesthetic aniline aminoacyl anesthetic anesthetic aminoacyl aniline [(hydroxyphenyl)ethylenediamine]platinum(II) complexes as [bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes binding to) Mammary gland (neoplasm [bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes inhibition of and estrogen receptor-binding in) hydroxyphenylethylenediamine platinum complex prepn cytotoxicity antitumor hydroxyphenylethylenediamine platinum complex estrogen receptor hydroxyphenylethylenediamine platinum complex [bis(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) as a novel Acyl groups (migration of administration & dosage Receptors administration & dosage Tumor Cells after menopause in women) breast tumor estrogen antiestrogen mammary carcinoma antiestrogen menopause after menopause in women) Mammary gland (neoplasm against hormone-dependent mammary and prostate gland cells) Reproductive organ (male accessory against mycobacteria) Mycobacterium bactericide synergism benzylamine Agar Animals Cell Survival Cisplatin: PD Al as) Reduction (of Schiff bases ALDIMINES CYTOSTATIC ETHYLENEDIAMINES ETHYLENEDIAMINES CYTOSTATIC alpha '-diethylstilbenediols) alpha '-diphenylethylenediamine partition between aq. solns. and org. solvents in relation to) alpha '-diphenylethylenediamines between aq. soln. and org. solvents) Hydration (chemical) (N Amides Role: RCT (Reactant) Amines (N-benzylidene Amines (sepn. of Amines Role: ANST (Analytical study) (sepn. of Amines Role: RCT (Reactant) Amines Role: USES (Uses) (effect on Schiff base redn. by activated aluminum) Reduction (of Schiff bases by activated aluminum amino acid antagonists as Amino acids Role: BAC (Biological activity or effector Amino acids Role: BIOL (Biological study) (antagonists Amino acids Role: SPN (Synthetic preparation) amino acyl-tRNA synthetase inhibition in relation to) Escherichia coli (benzylamines inhibition of growth and amino acyl-tRNA synthetases of) Mycobacterium tuberculosis (benzylamines inhibition of aminoacryldimethylaniline derivs. binding to) Isomerism and Isomers (stereo- aminoacryldimethylaniline derivs. in relation to) Membranes (protein aminoacyl tRNA synthetase inhibition in relation to) amino acid antagonist antiproliferation tRNA synthetase aminoacyl tRNA synthetase inhibitory and antileukemic activities of) Neoplasm inhibitors (leukemia aminoacyl-tRNA synthetase targeting in) amino acid antagonist aminoacyl synthetase synthetase antitumor amino acid antagonist aminoalkylating compds. as) aminoarylpropylene estradiol receptor inactivity propylene aminoaryl estradiol aminomethylating compds. as) aminomethylating substances as) Aminomethylation (by cancer-inhibiting substances) Cancer (inhibitors of amphetamine anesthetics analysis *Breast Neoplasms: DT analysis *Tamoxifen: AD and -diepoxyhexene and Antiseptics (synergistic and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II) and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyp Estrogen receptors Role: BSU (Biological study and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Estrogens Role: BAC (Biological activity or effector and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Molecular structure-biological activity relationship (estrogen receptor-binding and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) platinum chloro hydroxyphenylethylenediamine estrogen receptor binding ethylenediamine deriv platinum complex estrogen activity and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Receptors Role: BSU (Biological study Anesthetics (3-[(3-hydroxy-1-methylpropyl)amino]butyric acid derivs. as local) Anesthetics (aminoacyl 2 Anesthetics (ar-alkoxy-N-alkyl-alpha -phenylbenzylamines as) Schiff bases Role: RCT (Reactant) Anesthetics (cinchocaine homologs as local) cinchocaine homologs anesthetic activity anesthetic activity cinchocaine homologs dibucaine analogs anesthetics Nupercaine analogs anesthetics Anesthetics (local Anesthetics (local) Psychotherapeutic agents (parasympatholytic activity of) Parasympatholytic substances (psychotherapeutic agents as) Psychotomimetic agents (review on) Anesthetics (N-aminoacyl ephedrine isomers as local) Molecular structure-biological activity relationships (androgen-inhibiting Anesthetics (N-aminoacylephedrine derivs. as local) Nerves (blocking agents for Anesthetics (N-aminoacylephedrines as) AMINOACYLEPHEDRINES ANESTHETICS EPHEDRINES EPHEDRINES ANESTHETICS Anesthetics (pharmacology of local) anesthetics mechanism review review mechanism anesthetics Anesthetics (piperidinomethylbenzamide derivs. as local) piperidinomethylbenzamides local anesthetics local anesthetics anesthetics local benzamides local anesthetics ANESTHETICS BENZHYDRYLAMINES BENZHYDRYLAMINES ANESTHETICS Animal tissue culture (diamine ligand release from cisplatin analog in) diamine ligand release cisplatin analog cell Animals *Antineoplastic Agents Binding Animals *Antineoplastic Agents Cell Division: DE Animals *Antineoplastic Agents: PD anpirtoline carbon 14 piperidinethiol substitution chloropyridine carbon labeled antagonists of antibacterial activity of) Escherichia coli (inhibition of Antibiotics (amino acid antagonists Antidepressants (phenylalanylphenylalkylamine derivs. as Antidepressants (phenylalanylphenylalkylamines) Molecular structure-biological activity relationship (antidepressant antiestrogen and estrogen inhibition of antiestrogenic activity of) diphenylpyridylbutene estrogen pyridylbutene deriv antiestrogen antitumor butene deriv antiestrogen antitumor antiestrogenic and estrogenic activity in relation to) Estrogens Role: BIOL (Biological study) (neoplasm inhibition by bis(hydroxyphenyl)hexane in relation to) hydroxyphenylhexane antitumor mechanism antiestrogens inhibition of antiestrogens inhibition of) Animal cell (MCF-7 antiestrogens inhibition of) antiestrogen mammary carcinoma DMBA breast cancer antiestrogen estrogen antagonist mammary tumor Antihypertensives (norfenefrine azomethines) Ring closure and formation (oxazolidines from norfenefrine and aldehydes and ketones) antihypotensive norfenefrine azomethine hypertensive norfenefrine azomethine oxazolidine hydroxyphenyl cyclization norfenefrine aldehyde ketone condensation norfenefrine aldehyde ketone antimycobacteria compd. testing in relation to) Antibiotics (mycobacteria susceptibility to antimycobacterial compd. testing in relation to) Culture media (for mycobacteria antimycotic activity of Antineoplastic Combined Chemotherapy Protocols: PD Antitumor Humans Leukemia P388: PA antitumor activity in relation to) Estrogens Role: BIOL (Biological study) (receptors for antitumor activity in relation to) Molecular structure-biological activity relationship (estrogen receptor-binding antitumor activity in relation to) Neoplasm inhibitors (carcinoma antitumor activity in relation to) platinum complex nucleic acid metab antitumor platinum complex nucleic acid antitumor activity in relation to) Receptors Role: BIOL (Biological study) (for estrogens antitumor activity of antitumor activity of) Neoplasm inhibitors (diphenylpyridylbutenes as antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol antitumor activity platinum fluorophenylethylenediamine complex platinum fluorophenylethylenediamine diastereoisomer complex ethylenediamine fluorophenyl platinum diastereoisomer complex Antitumor agent resistance Antitumor agent resistance Complexation Mammary gland Prostate gland (optimization of cisplatin for treatment of hormone dependent tumoral diseases) DNA Estrogen receptors Role: BSU (Biological study Antitumor agent resistance Antitumor agent resistance Drug design Mammary gland Prostate gland (optimization of cisplatin for treatment of hormone-dependent tumoral diseases) review cisplatin complex hormone dependent tumor antitumor resistance Antitumor agents ([rac-1 Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm antitumor effect) antitumor mechanism in relation to) Deoxyribonucleic acids Role: BIOL (Biological study) (template activity of antitumor mechanism in relation to) Nucleic acids Role: BPR (Biological process) antitumor platinum compds. effect on app. for) attempted) Neoplasm inhibitors (bis(2-chloroethyl)aminomethyl amides) benzamide bischloroethylaminomethyl carcinostatic chloroethylaminomethylbenzamide carcinostatic sarcoma chloroethylaminomethylbenzamide acetamide trichloro carcinostatic Bactericidal action and Bacteriostatic action (of beta -aminoketones) Ketones Role: BIOL (Biological study) (beta -amino- Bactericides Bactericides Fungicides (amino ketones) Ketones Role: BIOL (Biological study) (amino benign hyperplasia benzylamine-contg. compns. benzylamine-contg. synergistic bactericides for) Bactericides between hydrochloric acid solns. and org. phase) Craig distribution alkylbenzylamines distribution Craig alkylbenzylamines alkylbenzylamines Craig distribution amines alkylbenzyl distribution benzylalkylamines distribution sepn alkylbenzylamines biocidal action of BIOL (Biological study) BIOL (Biological study) (alkyl esters BIOL (Biological study) (antimicrobial activity of BIOL (Biological study) (antimicrobial activity of) Molecular structure-biological activity relationships (antimicrobial BIOL (Biological study) (diphenylpyridylbutenes as inhibitors of BIOL (Biological study) (estrogen BIOL (Biological study) (inhibitors BIOL (Biological study) (optimization of cisplatin for treatment of hormone dependent tumoral diseases) review cisplatin carboplatin breast prostate cancer antitumor resistance BIOL (Biological study) (prepn. BIOL (Biological study) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) platinum chloro fluorohydroxyphenylethylenediamine prepn antitumor breast cancer BIOL (Biological study) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Receptors Role: BPR (Biological process) biological response modifiers bis(acetoxyphenyl)phenylbutenes as) styrylphenyl acetate prepn antitumor antiestrogenic styrylphenylacetate prepn bis(fluorohydroxyphenyl)dimethylbutane derivs.) bisfluorohydroxyphenyldimethylbutane deriv prepn antiestrogen activity estrogen inhibitor fluorohydroxyphenyldimethylbutane deriv bis(hydroxymethylphenyl)butane inhibition of) antiestrogen butestrol metabutestrol prepn estrogen receptor binding butestrol metabutestrol antitumor butanebis hydroxymethylphenyl structure activity butestrol metabutestrol antiestrogen bis(hydroxyphenyl)alkanes) mammary tumor inhibitor hydroxyphenylalkane prepn uterotropic hydroxyphenylalkane antiuterotropic hydroxyphenylalkane Grignard benzaldehyde chloromethoxyphenylalkane Grignard bis(hydroxyphenyl)phenylethene affinity for) Estrogens Role: BIOL (Biological study) (receptors bis(hydroxyphenyl)phenylethene affinity for) hydroxyphenylphenylethene crystal structure antiestrogen estrogen activity bis(hydroxyphenyl)phenylethene as) Receptors Role: BIOL (Biological study) (estrogen biscycloalkylamineplatinum dichloro antitumor prepn structure BPR (Biological process) BSU (Biological study butestrols and metabutestrols as) Neoplasm inhibitors (bis(hydroxymethylphenyl)butane as butestrols and metabutestrols binding by) Molecular structure-biological activity relationship (antiestrogenic by [bis(hydroxyphenyl)ethylendiamine]dichloroplatinum(II) by Al by amino acid antagonist targeting for aminoacyl-tRNA synthetases) Molecular structure-biological activity relationship (bactericidal by benzylamine by benzylamine-contg. synergistic bactericidal compns.) Leprosy Tuberculosis (treatment of by countercurrent partition) by countercurrent partition) Amino acids (resolution of by Craig partition) AMPHETAMINES SEPN PERVITAMINES SEPN EPHEDRINES SEPN by endocrine-active platinum complex) hormone dependent prostate tumor platinum complex endocrine active platinum complex prostate tumor mammary tumor endocrine active platinum complex by endocrine-active platinum complex) Mammary gland (neoplasm by Grignard reagents in presence of CoCl2) Schiff bases (redn. of by Grignard reagents in presence of CoCl2) Unsaturated compounds (spectra and structure of) by neoplasm by neutron activation anal.) Organ (platinum of antitumor drugs detn. in by neutron activation anal.) Radiochemical analysis (neutron activation by platinum compds.) dichlorohydroxyphenylethylenediaminedichlorplatinum antitumor prostate platinum compd antitumor prostate by platinum complexes of diaminoethanes) Neoplasm inhibitors (carcinoma by substitution reactions of N-carbethoxyphthalimide by tetramethylbis(hydroxyphenyl)ethanes) Molecular structure-biological activity relationship (neoplasm-inhibiting by tumor carbon 14 D16726 indole ethyl carbon 14 carboplatin deriv anticancer carcinoma Carcinoma (inhibitors of Carcinoma (of mammary gland chain branching in relation to) Chains (branching of chain length in relation to) aminonitriles Grignards reaction Grignards aminonitriles reaction nitriles amino Grignards reaction piperidine nitriles Grignards chemical synthesis *Estrogen Antagonists: PD chemoreceptors and) Hydrocinnamamide Role: BAC (Biological activity or effector chemosensitivity human melanoma cell cytostatic chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion) chemotherapy of) Carcinoma (of mammary gland chemotherapy of) review chemotherapy mastocarcinoma breast cancer chemotherapy review cinchocaine homologs as) review anesthetic lipid soly cinchocaine anesthetic soly review Circulation Heart ((methoxybenzamidomethyl)norephedrine and related compds. effect on) cardiovascular catechol amine deriv heart catechol amine deriv circulation catechol amine deriv blood pressure catechol amine deriv norephedrine analog heart circulation Circulation (N-aminoacyl ephedrine derivs. effect on heart) Nerves (blocking agents for cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of estrogens interaction with cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum interaction with cisplatin derivs. as cisplatin derivs. for) carcinoma mammary cisplatin review cisplatin antitumor platinum complex antitumor Competitive Estrogen Antagonists: CS Configuration Conformation and Conformers (prepn. Configuration (of dialkyldiphenylethylenediamines and -imidazolidine derivs.) NMR ethylenediamine imidazolidine diphenyl NMR configuration diphenylethylenediamine Conformation Stereochemistry (antitumor potency of diastereomeric and enantiomeric platinum diaminophenylpropane dichloro complexes in relation to) Structure-activity relationship (antitumor stereoselectivity of antitumor active [1 Conformation (of N Conformation and Conformers (of hydroxyphenylethylenediamine sulfatoplatinum complexes) Molecular structure-biological activity relationship (estrogenic Conformation and Conformers (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Estrogen receptors Role: BPR (Biological process) Conformers EHMO Hydrolysis Isomerization Molecular mechanics Molecular structure Total energy Transition state structure (mol.-mech. and quantum chem. study of species involved in hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes) Amines Role: PEP (Physical Cope rearrangement (of bis(hydroxyphenyl)ethylenediamine reaction products with fluorobenzaldehyde) Craig Craig distribution in) sepn amines Craig distribution amines sepn Craig distribution Craig distribution sepn amines distribution Craig sepn amines Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethane) mol structure chloromethoxyphenyl ethane Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethane) mol structure chloromethoxyphenylethane ethane chloromethoxyphenyl structure Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethene) mol structure chloromethoxyphenylethane ethane chloromethoxyphenyl structure crystal structure chloromethoxyphenylethane Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethene) mol structure chloromethoxyphenylethene crystal structure chloromethoxyphenylethene ethene chloromethoxyphenyl structure Crystal structure Molecular structure (of diazido(methoxyphenyl)phenylethane) crystal structure azidohydroxyphenylethylenediamine platinum hydroxyphenylethylinediamine complex ethylenediamine hydroxyphenyl platinum complex azidohydroxyphenylethylenediamine prepn structure Crystal structure Molecular structure (of platinum hydroxyphenylethylenediamine diastereomeric complexes) Substitution reaction (of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Kinetics of substitution reaction (coordinative culture media influence in) Albumins Ovalbumins Role: BIOL (Biological study) (culture media contg. culture media influence in) mycobacteria antibiotic test culture media albumin antimycobacteria compd test Cultured: DE D16427 carbon 14 labeled phenol araliph amino labeled dapsone and rifampicin enhancement of) benzylamine Mycobacterium inhibition dapsone rifampicin leprosy treatment benzylamine ME93 Mycobacterium inhibition Deoxyribonucleic acid formation (by neoplasm Deoxyribonucleic acid formation (inhibition of Deoxyribonucleic acids Role: BPR (Biological process) DES catechol analog interaction in) Carcinoma (of mammary gland DES catechol analogs inhibition of) DES catechol analog prepn estrogen carcinoma mammary inhibition DES analog uterus growth DES catechol analog DES catechol analogs inhibition of) Mammary gland (neoplasm detn. of dialkylbis(hydroxyphenyl)ethanes as) Molecular structure-biological activity relationship (antiestrogenic dialkylbis(hydroxyphenyl)ethanes inhibition of) Estrogens Role: BSU (Biological study dialkylbis(hydroxyphenyl)ethanes inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting dichlorobis(cycloalkylamine)platinum(II) complexes as dichlorobiscycloalkylamineplatinum antitumor prepn structure dichlorodipeptide ester platinum complex inhibition of) peptide platinum complex neoplasm inhibitor dichloroplatinum complexes dihydroxy(trifluoropropyl)benzanilide) hydroxybenzanilide trifluoropropyl trifluoropropylbenzanilide prepn antiestrogen Dimerization (of piperidineacetonitrile with tert-butylmagnesium chloride) nitriles aminodipiperidinocrotono crotononitriles amino piperidino piperidinocrotononitriles amino dimethylaniline and ephedrine enantiomers as) local anesthetic membrane protein nerve conduction anesthetic Disinfectants Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (dithiourethanes) dithiourethane fungistatic antibacterial dithiourethane dithiocarbamate fungistatic Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine Disinfectants and Antiseptics Neoplasm inhibitors (dichlorodipeptide ester platinum complexes) Deoxyribonucleic acids Proteins Ribonucleic acids Role: FORM (Formation Disinfectants and Antiseptics Neoplasm inhibitors (Mannich bases of dihydroxydiethylstilbenes) Mannich bases Role: BIOL (Biological study) (of dihydroxydiethylstilbenes) Mannich base stilbene antimicrobial antitumor antitumor Mannich base stilbene cytostatic Mannich base stilbene aminomethylstilbene cytostatic Disinfectants and Antiseptics (glycylglycine platinum complex) Neoplasm inhibitors (Walker 256 carcinosarcoma Disinfectants and Antiseptics (hydroxybenzamide derivs. as) Staphylococcus (aureus (includes albus and citreus) DNA formation ([Aqua-1-(2 drug effects *Tumor Stem Cell Assay drug effects 0 (Antineoplastic Agents) 0 (Estrogen Antagonists) 0 (Receptors drug effects 0 (Receptors drug effects Cell Line Leukemia L1210: DT drug therapy *Organometallic Compounds: TU drug therapy Breast Neoplasms: PA drug therapy Mammary Neoplasms drug therapy Mice *Neoplasms effect of aluminum and mercury salts and of amines on) MECHANISMS REDN SCHIFF BASE SCHIFF BASE REDN MECHANISMS REDNS ACTIVATED ALUMINUM ALUMINUM ACTIVATED REDNS effect of aluminum and mercury salts and of amines on) Schiff bases Role: PRP (Properties) (redn. by activated aluminum Ehrlich Tumor: PA elmustin carbon 14 endocrine-active platinum complex as endocrine-active platinum complex effect on engineering or chemical process) Escherichia coli (platinum complexes screening for neoplasm-inhibitory activity in) Neoplasm inhibitors (platinum-bis(oligopeptide ester) complexes as estradiol aminoethoxy platinum chloro estradiol antagonism of) Mammary gland (neoplasm estradiol receptor affinity Estradiol) Estradiol: DE estrogen receptor affinity estrogen receptors of Estrogen) estrogen-dependent Estrogen: AN Estrogen: ME estrogenic activity in estrogenic activity in relation to) Mammary gland Prostate gland (neoplasm estrogenic activity in relation to) Neoplasm inhibitors (prostate gland estrogenic activity in relation to) phenylethylenediamine platinum complex estrogenic crystal structure conformation phenylethylenediamine platinum complex estrogenic activity mammary cancer inhibitor phenylethylenediamine platinum complex estrogenic platinum(II) complex as) estrogenic platinum complex breast cancer inhibitor estrogenic platinum(II) complex as) Mammary gland (neoplasm estrogenic/antiestrogenic activity estrogenicity in relation to) Molecular structure-biological activity relationship (estrogenic Estrogens Role: BAC (Biological activity or effector Estrogens Role: BIOL (Biological study) ([(hydroxyphenyl)ethylenediamine]platinum(II) complexes as Estrogens Role: BIOL (Biological study) (and inhibitors Estrogens Role: BIOL (Biological study) (bis(hydroxyphenyl)phenylethene as) Crystal structure (of bis(hydroxyphenyl)phenylethene) Estrogens Role: BIOL (Biological study) (antiestrogens Estrogens Role: PRP (Properties) ((dichlorohydroxyphenyl)phenylethylenediamines and their platinum sulfato complexes) Neoplasm inhibitors (platinum complexes with (dichlorohydroxyphenyl)phenylethylenediamines) antitumor activity platinum phenylethylenediamine complex estrogenic property platinum phenylethyleneidamine complex amine phenylethylenedi platinum complex Estrogens Role: RCT (Reactant) Estrogens Role: USES (Uses) (inhibitors estrone aminoethoxy platinum chloro ethylenediamine deriv. in treatment of) cytostatic benzanthracene tumor ethylenediamine cytostat ethylenediamine deriv. in treatment of) Neoplasm (of mammary gland ethylenediamines diphenyl cytostatic cytostatic diphenylethylenediamines diphenylethylenediamines cytostatic diaminodiphenylethanes cytostatic amines araliph cytostatic anticancer ethylenediamines except adverse) Experimental: DT Experimental: ME Experimental: PA Experimental: PC Extraction apparatus (distribution Fever and Hyperthermia (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion) fluorophenyl ethylendiamine cyclobutane carboxylatoplatinum synthesis anticancer fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition followed by amidation and redn.) platinate chloro substituted ethylenediamine antitumor activity platinate chloro substituted ethylenediamine amino acid esterification amination amino acid ester amide prepn redn for amines) Amines Bases (extn. of for estrogen receptor-pos. tumors) Prostate gland (disease for human mammary carcinoma) epoxidn hexadiene epoxyhexene mammary carcinoma inhibitor diepoxyhexane mammary carcinoma inhibitor mammary carcinoma inhibitor epoxide tritiated estradiol receptor inhibition epoxide for mammary gland) Mammary gland (neoplasm for mammary tumors) Amines Role: SPN (Synthetic preparation) for mammary tumors) Estrogens Role: RCT (Reactant) FORM (Formation from DMBA fungicidal activity and partition coeffs. and soly. of) Partition (of amino ketones) cytostatic agent antibacteria agent antifungal compd bacteriostatic compd beta amino ketone fungistats Fungicides and Fungistats Neoplasm inhibitors (dithiocarbamic acid derivs.) aminal carcinostatic fungistatic thiocarbamate deriv carcinostatic fungistatic acetal carcinostatic fungistatic antitumor carbamate deriv Fungicides or Fungistats (diethylstilbestrol) Bactericidal action or Bacteriostatic action (of alpha Fungicides or Fungistats (hydroxyaryl amides as) Benzamide Benzamide Role: PREP (Preparation) glycylglycine Et ester platinum complex effect on glycylglycine platinum complex) Neoplasm inhibitors (sarcoma 180 glycylglycine platinum complex) Neoplasm inhibitors (yoshidasarcoma glycylglycine platinum complex) peptide platinum chloride complex bactericide glycylglycine platinum complex carcinostat glycylglycine platinum complex Grignard reaction (in Schiff base redn. in presence of CoCl2) Reduction (of Schiff bases Grignard reactions of Grignard reactions of amino nitriles in relation to) Grignard reaction (of amino nitriles Grignard reagent effect on) Grignard reaction (with Schiff bases) Grignard reagents Role: RCT (Reactant) growth of hexestrol deriv. binding by) Estrogens Role: BIOL (Biological study) (receptor for hexestrol deriv. binding by) Molecular structure-biological activity relationship (estrogen receptor-binding highly active carboplatin deriv. hormone dependence in) Mammary gland (neoplasm hormone dependence in) platinum complex mammary carcinoma inhibition hydroxyphenylethylenediaminedichloroplatinum mammary carcinoma inhibition hormone-dependent Hydrocinnamamide (anesthetic activity of) Hydrolysis Kinetics of hydrolysis (of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes Hydrolysis (of (+-)- threo- and erythro-1 Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity hydroxybenzamide deriv. effect on) Benzoic acid Benzoic acid Salicylic acid (bactericidal action of) hydroxyphenyl ethylenediamines ethylenediamines hydroxyphenyl amines ethylene phenols anisoles phenols anisoles amines ethylene anisoles phenols amines ethylene imidazolidines phenyl hydroxyphenylethylenediamine sulfatoplatinum complexes as hydroxyphenylethylenediamineplatinum complexes as hyperthermic limb perfusion cytostatic chemosensitivity Imines (reaction of ket- in alpha -(dimethylamino)-N-(beta -hydroxy-alpha -methylphenethyl)-N-methylhydrocinnamamide) EPHEDRINE STEREOISOMERISM STEREOISOMERISM EPHEDRINE PSEUDOEPHEDRINE STEREOISOMERISM in cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes undergoing hydrolysis in Escherichia coli) platinum complex antitumor screening Escherichia in estrophilic platinum complex effect on uterine morphol.) Estrogens Role: BIOL (Biological study) (receptors for in estrophilic platinum complex effect on uterine morphol.) estrophilic platinum complex uterus in human mammary gland) Mammary gland (neoplasm in human) aminoethane platinum complex prepn antitumor in human) Cytoplasm (cytosol in mammary gland in presence of transition metal halides) Transition metal halides (Grignard reaction with Schiff bases in presence of) Grignard reaction (with Schiff bases in presence of transition metal halides) in prostate) Prostate gland (neoplasm infrared (of N inhibition by bis(hydroxyphenyl)alkanes) Neoplasm inhibitors (mammary inhibition by hexafluorobis(hydroxyphenyl)butanes and -butenes) fluorinated bishydroxyphenylbutane antitumor hexafluorobishydroxyphenylbutane bishydroxyphenylbutane estrogenic hexafluorobishydroxyphenylbutane bishydroxyphenylbutane phenol hexafluorobutanediyl prepn antitumor inhibition of inhibition of hormone-dependent inhibitors inhibitors [Aqua-1-(2 inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector interferon and lymphotoxins effect on) Neoplasm inhibitors (carcinoma interferons and lymphotoxins as interferons and lymphotoxins effect on) Lymphokines and Cytokines Role: BIOL (Biological study) (tumor necrosis factor-beta Isomerism and Isomers (stereo- Isotopic effects (in redn. of Schiff bases with Al catalyst) Catalysts and Catalysis (in redn. Ketones Role: BIOL (Biological study) (amino Kidney Neoplasm Organ (platinum complex uptake by) platinum complex tumor uptake antitumor platinum complex kidney uptake Kinetics of metalation (cycloplatination lipid soly. in relation) ephedrine diastereoisomer anesthetic lipid soly ephedrine anesthetic Lipids Role: BIOL (Biological study) (anesthetic diastereomers of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine soly. in) Molecular structure-biological activity relationship (anesthetic liver function in relation to) Local *Chemistry local chemistry Local) mammary mammary carcinoma inhibition by) Carcinoma (of mammary gland mammary estrogen receptor binding in relation to) Estrogens Role: BIOL (Biological study) (receptors for Mammary gland (cancer of Mammary gland (carcinoma Mammary gland (neoplasm Mammary gland (neoplasm of mammary gland carcinoma of humans response to mammary gland carcinoma response to interferon and) Interferons Role: BIOL (Biological study) (gamma mammary gland carcinoma response to lymphotoxin and) breast cancer inhibition interferon lymphotoxin mammary carcinoma inhibition interferon lymphotoxin Mannich bases Role: BAC (Biological activity or effector mechanism of mechanism of action of) review local anesthetic nerve anesthetic review mechanism of) Fungicides and Fungistats (beta -aminoketones as) review aminoketone antimycotic mechanism fungus aminoketone review mechanism of) Kinetics (of inhibition mechanism of) REDN DIMERS BENZYLIDENE AMINES BENZYLIDENE AMINES REDN DIMERS AMINES BENZYLIDENE REDN DIMERS mechanism of) Schiff bases (redn. of mechanism of) Schiff bases Role: PRP (Properties) (redn. by activated aluminum membrane binding in relation to) anesthetic interaction membrane protein ephedrine isomer anesthesia membrane menopause in relation to) Carcinoma (of mammary gland mesohexestrol derivs. by) metahexestrol deriv prepn estrogen antiestrogen hexanediol diphenyl deriv metabolism Mammary Neoplasms metabolism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organometallic Compounds) 0 (Receptors metahexestrol derivs.) Molecular structure-biological activity relationship (antiestrogenic MFM (Metabolic formation) Mn salt effect on) Mn salt effect on) Grignard reaction (with Schiff bases mol. mech. and quantum chem. study of) cisplatin hydrolysis mol mechanic quantum chem ammine chloro platinum hydrolysis kinetics ethylenediamine chloro platinum hydrolysis kinetics mol. mech. and quantum chem. study of) Molecular mechanics Quantum chemistry (of hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes) Energy level (electronic mol. structure) Molecular structure ([rac-1 Molecular structure-biological activity relationship (anesthetic Molecular structure-biological activity relationship (local anesthetic Molecular structure-biological activity relationship (neoplasm-inhibiting Molecular structure-biological activity relationships (fungicidal Muscle relaxants (alkyl[(diphenylacetamido)methyl]dimethylammonium iodides) phenylacetamidomethylammonium iodide spasmolytic acetamidomethylammonium ammonium diphenylacetamidomethyl iodide acetamidomethylammonium iodide Mycobacterium (control of Mycobacterium leprae (inhibition of Mycobacterium tuberculosis (antibiotic susceptibility of N'-dibutyl-1 N'-dibutyl-alpha N-aminoacyl ephedrine derivs. as) Heart (circulation in N-aminoacyl ephedrine derivs. effect on) Anesthesia (from N-aminoacyl ephedrine derivs.) LOCAL ANESTHETICS MOL CONFIGURATION LOCAL ANESTHETICS EPHEDRINES NERVE EFFECT NERVE EFFECT EPHEDRINES RECEPTOR EPHEDRINES BINDING N-aminoacylephedrine derivs. as Neoplasm (platinum detn. in neoplasm inhibiting activity in relation to) acetoxyphenylindene ethylmethylacetoxy prepn tumor inhibitor indene acetoxyphenyl anticancer neoplasm inhibition in relation to) Deoxyribonucleic acids Role: PRP (Properties) (interaction of neoplasm inhibition in relation to) Neoplasm inhibitors (platinum compds. neoplasm inhibition in relation to) Neoplasm inhibitors (platinum-peptide ester complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting neoplasm inhibition in relation to) Protein formation (antitumor platinum compds. effect on neoplasm inhibition mechanism in relation to) cis platinum antitumor mechanism neoplasm inhibition mechanism in relation to) Estrogens Role: BIOL (Biological study) (receptors for neoplasm inhibition mechanism in relation to) Neoplasm inhibitors (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum as) Deoxyribonucleic acid formation (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of Neoplasm inhibitors ((acetoxyphenyl)hexadiene Neoplasm inhibitors ((diphenylethylenediamine) platinum II complexes) diphenylethylenediamine platinum complex formulation antitumor diphenylethylenediamine platinum complex Neoplasm inhibitors ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides) Uterus ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides effect on) Estrogens Role: RCT (Reactant) Neoplasm inhibitors ([(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting Neoplasm inhibitors ([bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes Neoplasm inhibitors (acetoxy(acetoxyphenyl)ethylmethylindene) Receptors Role: RCT (Reactant) Neoplasm inhibitors (antiestrogens) Estrogens Role: BSU (Biological study Neoplasm inhibitors (antiestrogens) Menopause (antiestrogens and estrogens effect on mammary carcinoma in humans in relation to) Estrogens Role: BIOL (Biological study) (inhibitors and Neoplasm inhibitors (bis(acetoxyphenyl)phenylbutenes) Estrogens Role: USES (Uses) (inhibitors Neoplasm inhibitors (bis(chloroethyl)aminomethylurethanes) chloroethylaminomethylurethane neoplasm inhibitor urethane chloroethylaminomethyl neoplasm inhibitor sarcoma inhibitor chloroethylaminomethylurethane cytostatic chloroethylaminomethylurethane Neoplasm inhibitors (bis(hydroxyphenyl)hexane as Neoplasm inhibitors (carcinoma Neoplasm inhibitors (cis-dichlorobis(alpha -amino acid ester) platinum complexes) amino acid platinum antitumor Neoplasm inhibitors (DES catechol analogs) Uterus (DES catechol analogs effect on growth of) Receptors Role: BIOL (Biological study) (estradiol binding by Neoplasm inhibitors (dialkylbis(hydroxyphenyl)ethanes as) Receptors Role: BIOL (Biological study) (estradiol binding by Neoplasm inhibitors (dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers Neoplasm inhibitors (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) Neoplasm inhibitors (estrophilic platinum complex as Neoplasm inhibitors (ethylenediamine platinum complexes) ethylenediamine platinum complex antitumor prepn Neoplasm inhibitors (excitatory amino acid antagonists as) Amino acids Role: BIOL (Biological study) (excitatory Neoplasm inhibitors (glycylglycine Et ester platinum complex) Deoxyribonucleic acid formation Ribonucleic acid formation (glycylglycine Et ester platinum complex inhibition of Neoplasm inhibitors (hexafluorobis(hydroxyphenyl)butanes and -butenes Neoplasm inhibitors (lymphocytic leukemia Neoplasm inhibitors (mammary gland Neoplasm inhibitors (mammary gland carcinoma Neoplasm inhibitors (melanoma Neoplasm inhibitors (platinate chloro substituted-ethylendiamine complexes) Amino acids Role: RCT (Reactant) Neoplasm inhibitors (platinated DNA after treatment of cancer cells with new platinum complexes) Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as) Neoplasm inhibitors (platinum benzylethylenediamine complexes as) platinum benzylethylenediamine prepn antitumor agent Neoplasm inhibitors (platinum bis(difluorohydroxyphenyl)ethylenediamine complexes Neoplasm inhibitors (platinum bis(hydroxypheny)ethylenediamine complexes Neoplasm inhibitors (platinum chloro complexes with pyridylalkyleneamines and pyridylalkylamines and quinolylalkylamines as) platinum diamine prepn antitumor activity pyridylalkyleneamine platinum chloro pyridylalkylamine platinum chloro quinolylalkylamine platinum chloro Neoplasm inhibitors (platinum complex of phenylindoles) tumor inhibitor indole platinum complex prepn Neoplasm inhibitors (platinum complexes with bis(fluorophenyl)ethylenediamines) Neoplasm inhibitors (platinum complexes with bis(hydroxyphenyl)ethylenediamines or bis(methoxyphenyl)ethylenediamines) antitumor activity platinum methoxyphenylethylenediamine ethylenediamine methoxyphenyl platinum complex Neoplasm inhibitors (platinum diphenylethylenediamine complexes) platinum phenylethylenediamine prepn antitumor agent Neoplasm inhibitors (platinum phenylindolealkyleneamino complexes) platinum phenylindolealkyleneamine complex prepn antitumor Neoplasm inhibitors (stilbestrol analogs as) stilbestrol deriv antitumor aminostilbestrol cancer inhibition carcinoma mammary aminostilbene Neoplasm inhibitors (tetramethylbis(fluorohydroxyphenyl)ethane derivs. Neoplasm inhibitors (triphenylbutenes) phenylbutene prepn neoplasm inhibitor butene triphenyl neoplasm inhibitor Neoplasm inhibitors Role: BAC (Biological activity or effector neoplasm-inhibiting activity in relation to) Neoplasm inhibitors (platinum complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting Neoplasms (inhibitors of Nerve (Ranvier node nerve receptor and) EPHEDRINES PHENYLALANINE PHENYLALANINE EPHEDRINES ANESTHETICS EPHEDRINES Nerves (anesthetic effect on) Fungicides or Fungistats (hydroxyaryl amides as) Nitriles Role: RCT (Reactant) nonpreparative) nonpreparative) (formation of normal uterine morphol. response to) Uterus (estrophilic platinum complex effect on morphol. of Nucleic acids (in liver function test) Liver (nucleic acid metabolism by of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers) Anesthesia (from (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers of [(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) platinum complex stereoisomer antitumor structure of [(hydroxyphenyl)ethylenediamine]platinum(II) complexes) Neoplasm inhibitors (mammary gland of alkylbenzylamines) alkylbenzylamine tuberculostatic Mycobacterium alkylbenzylamine benzylamine alkyl tuberculostatic of amino acid antagonists targeting for aminoacyl-tRNA synthetases) aminoacyl tRNA synthetase inhibitor antibacterial of amino ketones) Bactericidal action (of amino ketones) fungistatic compd bacteriostatic compd antimicrobial compd germicidal compd amino ketone germicide propiophenones germicide of aminoacryldimethylaniline derivs.) Anesthetics (membrane binding of of aminoacylphenylalkylamines) phenylalanylphenylalkylamine antidepressant of aminoketones) amino ketone fungicides fungicides amino ketone ketone amino fungicides propiophenones fungicides of aminoketones) Bactericidal action (of aminoketones) aminoketones stability antimicrobial activity antimicrobial activity aminoketones stability ketone antimicrobial activity aminopropiophenones antimicrobial activity of ammine phenylalkylamine complexes) Chromatography (high-performance of ammine phenylalkylamine complexes) Hydrolysis Kinetics of hydrolysis (of platinum ammine phenylalkylamine complexes) Metalation (cycloplatination of bis(3-hydroxyphenyl)ethylenediamine and their platinum complexes) hydroxyphenylethylenediamine stereoisomer platinum hydroxyphenylethylenediamine stereoisomer amine hydroxyphenylethylenedi platinum stereoisomer of butestrols and metabutestrols) Mammary gland (neoplasm of butestrols and metabutestrols) Molecular structure-biological activity relationship (estrogen receptor-binding of cinchocaine homologs) Anesthetics (local of D-homosteroids and 1 of dialkylbis(hydroxyphenyl)ethanes) alkylbishydroxyphenylethane prepn antiestrogen phenylethane dialkylbishydroxy antiestrogen antitumor estrogen inhibitor dialkylbishydroxyphenylethane neoplasm inhibitor dialkylbishydroxyphenylethane of dialkylbis(hydroxyphenyl)ethanes) Mammary gland (neoplasm of dichlorobis(cycloalkylamine)platinum(II) complexes) of dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers) ethylenediamineplatinum antitumor structure activity platinum complex antitumor structure activity of dimethylphenylalanylephedrine of hexestrol derivs.) hydroxyphenylethane prepn estrogen receptor binding hexestrol deriv estrogen receptor binding structure activity hexestrol deriv of human mammary carcinoma of hydroxyphenylethylenediamine sulfatoplatinum complexes) Neoplasm inhibitors (mammary gland of hydroxyphenylethylenediamineplatinum complexes) hydroxyphenyl ethylenediamine platinum mammary tumor inhibitor of mammary gland) Mammary gland (neoplasm of mammary gland) Receptors Role: BIOL (Biological study) (for estrogen of mammary tumors of metahexestrol derivs.) Coupling reaction (reductive of metahexestrol derivs.) Molecular structure-biological activity relationship (estrogenic of N-alkylbenzylamines) benzylamine deriv Mycobacterium inhibition tuberculostat benzylamine deriv of N-aminoacyl ephedrine stereoisomers) ANESTHETIC EFFECT AMINOACYL EPHEDRINES AMINOACYL EPHEDRINES ANESTHETIC EFFECT EPHEDRINES STEREOISOMERS ANESTHESIA of phenylalanyl-tRNA synthetases of Mycobacterium tuberculosis and Escherichia coli) bactericide benzylamine aminoacyl tRNA synthetase inhibition bacteria aminoacyl tRNA synthetase inhibition benzylamine benzylamine antimycobacterial activity mechanism mycobacteria sensitivity benzylamine mechanism of phenylalanylphenylalkylamines) phenylalanylphenylalkylamine deriv antidepressant structure of phenylpropanols and propiophenones of platinum amine phenylalkylamine complexes) orthoplatination ammine methoxyphenylalkylamine isomer complex platinum isomer complex methoxyphenylalkylamine kinetics hydrolysis platinum isomer complex of platinum bis(difluorohydroxyphenyl)ethylenediamine complexes) antitumor agent platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex of platinum complexes) platinum complex antitumor structure estrogen receptor platinum complex antitumor of platinum hydroxyphenylethylenediamine complexes) Neoplasm inhibitors (leukemia of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Isomerism and Isomers (diastereo- of platinum of antitumor drugs in organs and tumor tissues) platinum drug detn tissue neutron activation neutron activation analysis platinum drug tissue phosphorus tissue neutron activation analysis molybdenum tissue neutron activation analysis gold tissue neutron activation analysis trace element tissue neutron activation analysis of platinum-peptide ester complexes) antitumor platinum peptide complex structure antitumor activity platinum complex of quaternary aminoketones) Bactericidal action (of quaternary aminoketones) antimicrobials aminoketones aminoketones antimicrobials quaternary aminoketones fungicides fungicides quaternary aminoketones aminopropiophenones quaternization fungicides propiophenones antimicrobials of Schiff bases of stilbene derivs.) Mammary gland (neoplasm of stilbene derivs.) mammary neoplasm inhibitor stilbene structure activity stilbene of tetramethylbis(hydroxyphenyl)ethanes) Mammary gland (neoplasm of tetramethylbis(hydroxyphenyl)ethanes) methylbishydroxyphenylethane prepn antiestrogen antitumor butestrol deriv prepn antiestrogen antitumor metabutestrol deriv prepn antiestrogen antitumor antiestrogen butestrol metabutestrol deriv mammary antitumor butestrol metabutestrol deriv structure activity methylbishydroxyphenylethane of uterus orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Mammary gland Prostate gland (neoplasm orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Neoplasm inhibitors (prostate gland orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) platinum complex antitumor breast prostate cancer Partition (of alkylbenzylamine mixts. Partition (of aminoacyl ephedrines between aq. solns. and org. solvents) Partition (of aminoacylephedrines) Benzyl alcohol Role: PROC (Process) (sepn. of partition between aq. solns. and org. solvents in relation to) Partition (of N pathology *Mammary Neoplasms pathology *Organoplatinum Compounds: TU pathology Carcinoma pathology Cell Line Drug Screening Assays pathology Humans *Interferons: AD Pharmaceutical *Ephedrine *Research 0 (Anesthetics pharmaceutical ephedrine experimental lab study *Amphetamine *Anesthetics Pharmaceutical dosage forms (hydrosols pharmacology *Antineoplastic Combined Chemotherapy Protocols: TU pharmacology *Colony-Forming Units Assay Freezing Mice Tissue Preservation *Tumor Cells pharmacology Breast Neoplasms: PA pharmacology Mammary Neoplasms pharmacy - sterilization phenylalanylaminophenylpropane prepn pharmacokinetics aminophenylpropane deriv pharmacokinetics amphetamine phenylpyridylbutene pyridylbutene alkoxyphenyl tamoxifen diphenylpyridylbutene analog piperidino acetonitriles acetonitriles piperidino piperidino acetonitriles Na ammonia acetonitriles piperidino Na ammonia ammonia Na piperidino acetonitriles sodium ammonia piperidino acetonitriles nitriles aceto piperidino platinum prepn. platinum compd. as platinum complex antitumor platinated DNA platinum complex inhibition of platinum complex prepn stability neoplasm inhibition platinum complexes platinum complexes prepn. and stereoselectivity in antitumor activity of [1 platinum complexes antitumor effects and binding to mammary) Mammary gland (neoplasm platinum complexes antitumor effects and binding to mammary) Neoplasm inhibitors (platinum complexes as platinum complexes cytotoxicity in relation to binding to) platinum complex antitumor mammary estrogen receptor platinum complexes interaction with platinum complexes of diaminoethanes as platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma platinum cycloalkylamine chloro antitumor prepn structure platinum hydroxyphenylethylenediamine diastereomeric complexes as) crystal structure platinum hydroxyphenylethylenediamine complex leukemia inhibitor platinum hydroxyphenylethylenediamine complex kinetics substitution halo platinum hydroxyphenylethylenediamine complex platinum hydroxyphenylethylenediamine structure substitution kinetics platinum sulfato or sulfopropionato complexes with diarylethylenediamines) antitumor agent platinum ethylenediamine sulfopropionato sulfato platinum sulfato or sulfopropionato complexes with diarylethylenediamines) Mammary gland (neoplasm platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) platinum-peptide ester complexes inhibition of PREP (Preparation) PREP (Preparation) fluorophenylethylenediamine platinum complex ethylenediamine fluorophenyl platinum complex PREP (Preparation) (arom. amide derivs. PREP (Preparation) (bis(difluorosalicylidene)diphenylethylenediamine PREP (Preparation) (carboxylic acid PREP (Preparation) (di- PREP (Preparation) (diamines PREP (Preparation) (mammary gland PREP (Preparation) (N-phthalyl PREP (Preparation) (neoplasm PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its Estrogen receptors Role: PRP (Properties) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) Receptors Role: PRP (Properties) (estrogen PREP (Preparation) (transition metal complexes prepn. prepn. and acid hydrolysis of) Amines Role: SPN (Synthetic preparation) prepn. and anti-mammary tumor activity of) antitumor activity platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex prepn. and antitumor activity of) Cytotoxic agents Neoplasm inhibitors (dichloro(amino acid)platinum complexes) Alcohols Role: RCT (Reactant) prepn. and cytotoxicity and estrogen receptor-binding activity of) Receptors Role: BIOL (Biological study) (for estrogen prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) estrogen activity dichlorohydroxybenzylamine platinum complex prepn. of prepn. of fluorophenyl- and difluorophenyl(p platinum fluorophenylethylenediamine deriv diastereomer prepn antitumor antitumor breast platinum fluorophenylethylenediamine deriv diastereomer prepn. of fluorophenyl- and difluorophenyl(ph Mammary gland Role: BAC (Biological activity or effector prepn. of) amino acid amide xylyl phenylalkyl aniline dimethyl aminoacyl benzylamine aminoacyl phenethylamine aminoacyl prevention & control Mice Receptors PROC (Process) ([Aqua-1-(2 PROC (Process) (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) platinum compd cytotoxicity DNA platination tumor diaquadiphenylethylenediamine platinum cytotoxicity DNA platination tumor PROC (Process) (estrogen PROC (Process) (metab. of PROC (Process) (platinated DNA after treatment of cancer cells with new platinum complexes) PROC (Process) (platinum complexes mol.-mech. and quantum chem. study of species involved in hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes) amminechloroplatinum complex hydrolysis transition state simulation ethylenediaminechloro platinum complex hydrolysis mol mechanic EHMO amminechloroplatinum complex hydrolysis transition state PROC (Process) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Estrogens Role: BSU (Biological study prostatic tumor inhibition in relation to) Prostate gland (neoplasm protein formation inhibition as mechanism of action of) protein formation antitumor platinum PRP (Properties) quant.) racemization in) phthalyl amino acid substitution amino acid racemization carbethoxyphthalimide substitution racemization phthalyl amino acid racemization in) Racemization (in substitution reactions of amino acids with N-carbethoxyphthalimide) Substitution reaction (of N-carbethoxyphthalimide with amino acids RACT (Reactant or reagent) (aliph. RACT (Reactant or reagent) (alkynyl and alkyl RACT (Reactant or reagent) (alpha -amino RACT (Reactant or reagent) (alpha -amino) aminonitrile reaction alkyne Grignard arylalkyne amino nitrile amino reaction alkyne RACT (Reactant or reagent) (amino RACT (Reactant or reagent) (amino) piperidinoacetonitrile Grignard adduct adduct Grignard piperidinoacetonitrile Grignard adduct piperidinoacetonitrile Dimerization piperidinoacetonitrile amino dipiperidinocrotonitrile dipiperidinocrotonitrile amino RACT (Reactant or reagent) (aminoacylation of RACT (Reactant or reagent) (and inhibitors RACT (Reactant or reagent) (antagonists RACT (Reactant or reagent) (for estrogens RACT (Reactant or reagent) (Mannich reaction with bis(chloroethyl)amine RACT (Reactant or reagent) (prepn. and esterification of RACT (Reactant or reagent) (prepn. and reaction of RACT (Reactant or reagent) (prepn. properties and reactions of) review amine heterocyclic amine review arom amine review aliph amine review RACT (Reactant or reagent) (receptor for reaction of reaction with aminonitriles) piperidino alkyne alkane piperidino parasympatholytic reaction with Mg-MgI2 mixt.) Magnesium Role: PREP (Preparation) Magnesium Magnesium iodide (reaction with N-benzylidene alkyl amines) receptor binding in relation to) Neoplasm inhibitors (tetramethylbis(hydroxyphenyl)ethanes) Molecular structure-biological activity relationship (antiestrogenic Receptors Role: BIOL (Biological study) (estrogen Receptors Role: BIOL (Biological study) (for estrogen Receptors Role: BIOL (Biological study) (for estrogens Receptors Role: PROC (Process) (for estrogen redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Molecular structure-biological activity relationship (estrogenic redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Mammary gland (neoplasm redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Molecular structure-biological activity relationship (neoplasm-inhibiting redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Neoplasm inhibitors (mammary gland redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) phenylethyleneamine platinum complex mammary antitumor estrogenic mammary cancer inhibitor phenylethyleneamine platinum complex redn. of) Reduction (of alpha -amino nitriles) Nitriles (redn. of) Reduction (of Schiff bases by activated aluminum Resolution (by countercurrent extn.) Extraction (countercurrent Resolution (of amino acids resolution of optical isomers by) Isomerism (diastereo- Ribonucleic acids Role: RCT (Reactant) Schiff bases (Grignard reaction of Schiff bases (Grignard reactions of Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases) Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases) Amines (N-benzylidene Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases) Magnesium (reaction with N-benzylideneethylamine) Schiff bases (Grignard reactions of) Substituents (dimerization of Schiff bases in presence of Grignard reagents in relation to) Polymerization (dimerization of Schiff bases Schiff bases (reactions of) Schiff bases (reactions of Schiff bases Role: SPN (Synthetic preparation) screening of sepn. by countercurrent extn.) solvent effect on) solvent effect on) Schiff bases (redn. of Solvents (in Schiff base redn. by Al) Reduction (of Schiff bases SPN (Synthetic preparation) stability stilbene derivs. antagonism of) Estrogens Role: BIOL (Biological study) (receptor for stilbene derivs. antagonism of) Neoplasm inhibitors (stilbene derivs. as) Mammary gland (neoplasm stilbene derivs. as stilbene derivs. binding by stilbene derivs. inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting structure in relation to) structure in relation to) Bactericides Fungicides (aminoketones) Molecular structure-biological activity relationships (biocidal structure in relation to) Conformation and Conformers (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes) Crystal structure (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes structure in relation to) Molecular structure-biological activity relationship (antidepressant structure in relation to) Molecular structure-biological activity relationship (neoplasm-inhibiting structure in relation to) Molecular structure-biological activity relationships (antimicrobial structure platinum ethyl glycylglycinate chloro platinum peptide amino acid ester structure-activity relations of) estrogenic platinum complex conformation structure-activity relations of) Mammary gland (neoplasm Structure-activity relationship (antitumor prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Antitumor agents Conformation Human Mammary gland (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Estrogen receptors Role: BSU (Biological study structure-activity relationship of) Mammary gland (neoplasm structure-activity relationship of) Molecular structure-biological activity relationship (neoplasm-inhibiting synthesis targeting for aminoacyl-tRNA synthetases targeting for aminoacyl-tRNA synthetases) Amino acids Role: BIOL (Biological study) (antagonist of tetramethylbis(fluorohydroxyphenyl)ethane for) fluorohydroxyphenylethane prepn neoplasm inhibitor antiestrogen fluorohydroxyphenylethane estrogen inhibitor fluorohydroxyphenylethane tetramethylbis(fluorohydroxyphenyl)ethane for) Mammary gland Prostate gland (neoplasm tetramethylbis(hydroxyphenyl)ethanes tetramethylbis(hydroxyphenyl)ethanes binding by) Estrogens Role: BSU (Biological study therapeutic use Breast Neoplasms: AN therapeutic use Receptors therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds) therapy of thiourethanes antimicrobial antimicrobial thiourethanes urethanes dithio prepn cytostatic thiourethanes THU (Therapeutic use) toward mammary tumors) Isomerism and Isomers (diastereo- Transition metal complexes Role: BAC (Biological activity or effector treatment of Tuberculostatics (alkylbenzylamine) Molecular structure-biological activity relationship (tuberculostatic Tuberculostatics (benzylamines as Tuberculostatics (N-alkylbenzylamines) Mycobacterium (N-alkylbenzylamines sensitivity of) Molecular structure-biological activity relationship (tuberculostatic unclassified) USES (Uses) (anesthetic activity of Uterus (estrogen receptors of water soly. with Al amalgam and with Mg-MgI2 mixts.) Schiff bases (reactions of) Magnesium Magnesium iodide (reaction with ketimines) with Al catalyst with Al catalyst) with amino acid platinum complexes in hydrochloric acid presence) chloro amino acid platinum cytostatic with Mg-MgI2 mixts.) Magnesium Magnesium iodide (reaction with Schiff bases) with phenyllithium) AMINES BENZHYDRYL ALKYL BENZHYDRYL ALKYL AMINES ALKYL BENZHYDRYL AMINES with platinum complexes of diaminoethanes with platinum-peptide ester complexes with sodium in presence of toluene) nitriles amino dimerization amino nitriles dimerization benzyl amines dimers dimers amines benzyl
Number of items at this level: 881.

(acetoxyphenyl)indene deriv. binding by

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

(diethylcyclopropanediyl)bis(phenyl) diacetates for treatment of human) ethylcyclopropanediylbisphenyl diacetate antitumor stilbene analog mammary carcinoma estrogen receptor stilbene analog

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

(dimethylphenylalanyl)ephedrine stereoisomers inhibition of elec. activity of) nerve sodium cond ephedrine deriv anesthetic nerve sodium cond

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node. Pharmazie 27 (12), pp. 759-760.

(hydroxyphenyl)(trifluoropropyl)hydroxybenzamides as) hydroxyphenylbenzamide prepn antiestrogenic antitumor uterus hydroxyphenylbenzamide prepn

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Schönenberger, Helmut (1990) Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity. Archiv der Pharmazie 323 (2), pp. 73-78.

-epoxyhexene

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, Hans P. (1982) Syntheses and evaluation of the potentially estrophilic cytostatics. 2,3-Epoxy-3,4-bis(4'-acetoxyphenyl)-4-hexene and 2,3,4,5-bisepoxy-3,4-bis(4'-acetoxyphenyl)hexane. Archiv der Pharmazie 315 (6), pp. 515-519.

1-(2

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

1-dicarboxylato]platinum(II)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Amines Role: BAC (Biological activity or effector

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) Antitumor agents (prepn. and stereoselectivity in antitumor activity of [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-diamino-1-phenylpropane]dichloroplatinum(II) complexes) platinum diaminophenylpropane chloro prepn antitumor activity stereoselectivity antitumor activity platinum diaminophenylpropane chloro phenylpropanediamine platinum chloro prepn antitumor activity diamine platinum chloro prepn antitumor activity conformation platinum diaminophenylpropane chloro isomer

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

2-diphenylethylenediamine

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

2-diphenylethylenediamine diastereomers) Ethylenediamine Role: PREP (Preparation)

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

2-methylene steroids) Molecular structure-biological activity relationships (anesthetic

Brinkmann, Rolf and Schönenberger, Helmut and Petter, Alfred and Fuchsberger, K. D. and Zwez, W. (1967) Chemistry and local anesthetic effect of stereoisomeric N-aminoacyl ephedrines. Pharmaceutica acta Helvetiae 42 (8-10), pp. 576-592.

3-dibutyl-4

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

5-diphenylimidazolidine) Conformation Spectra

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

6-dic Structure-activity relationship (antitumor [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-Dichloro-4-hydroxyphenyl)-2-phenylethanes

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Antitumor agents (mammary gland [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) antitumor breast phenylethylenediamine platinum complex

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Estrogens Role: BAC (Biological activity or effector

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in 2-Ph ring 3. Investigation of breast cancer inhibiting properties) Mammary gland (neoplasm

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

6-xylidides) aminoacyl aniline anesthetic aniline aminoacyl anesthetic anesthetic aminoacyl aniline

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1968) Enantiomeric local anesthetics of the N-aminoacyl-2,6-dimethylaniline type. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 301 (10), pp. 780-785.

[(hydroxyphenyl)ethylenediamine]platinum(II) complexes as

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

[bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes binding to) Mammary gland (neoplasm

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

[bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes inhibition of and estrogen receptor-binding in) hydroxyphenylethylenediamine platinum complex prepn cytotoxicity antitumor hydroxyphenylethylenediamine platinum complex estrogen receptor hydroxyphenylethylenediamine platinum complex

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

[bis(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) as

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

a novel

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Acyl groups (migration of

Schönenberger, Helmut and Fuchsberger, K. D. and Brinkmann, Rolf (1967) Separation of the organic bases by Craig partition. VII. Acyl migration in the stereoisomeric N-(N,N-dimethylphenylalanyl)ephedrines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (2), pp. 126-135.

administration & dosage Receptors

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

administration & dosage Tumor Cells

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

after menopause in women) breast tumor estrogen antiestrogen mammary carcinoma antiestrogen menopause

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

after menopause in women) Mammary gland (neoplasm

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

against hormone-dependent mammary and prostate gland cells) Reproductive organ (male accessory

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

against mycobacteria) Mycobacterium bactericide synergism benzylamine

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

Agar Animals Cell Survival Cisplatin: PD

Krischke, W. and Hartmann, R. and Schneider, M. and Schönenberger, Helmut (1988) A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay. Journal of cancer research and clinical oncology 114 (2), pp. 170-176.

Al as) Reduction (of Schiff bases

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

ALDIMINES CYTOSTATIC ETHYLENEDIAMINES ETHYLENEDIAMINES CYTOSTATIC

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. VII. Effect of aldimine structure on the N,N'-dialkyl-alpha ,alpha '-diphenylethylenediamine-benzylalkylamine ratio formed in the reduction of benzylidenealkylamines with activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (6), pp. 483-491.

alpha '-diethylstilbenediols)

Schönenberger, Helmut and Adam, Dieter (1966) The cytostatic effect of isomeric diethylstilbestrols. IV. Antimycotics. Arzneimittel-Forschung = Drug research 16 (6), pp. 738-740.

alpha '-diphenylethylenediamine partition between aq. solns. and org. solvents in relation to)

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

alpha '-diphenylethylenediamines between aq. soln. and org. solvents) Hydration (chemical) (N

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

Amides Role: RCT (Reactant)

Schönenberger, Helmut and Bindl, L. and Adam, A. (1973) Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides. Archiv der Pharmazie 306 (1), pp. 64-75.

Amines (N-benzylidene

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reduction of benzylidene alkylamines with activated aluminum in alcoholic solution. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 373-375.

Amines (sepn. of

Schönenberger, Helmut and Thies, Heinrich and Borah, K. (1959) Quantitative separation of amine mixtures by Craig partition. Naturwissenschaften 46, pp. 144-145.

Amines Role: ANST (Analytical study) (sepn. of

Schönenberger, Helmut and Thies, Heinrich and Borah, Kripanath (1970) Quantitative determination of amine mixtures by multiplicative distribution. IX. Separation of organic bases by Craig distribution. Fresenius' Zeitschrift für analytische Chemie 251 (5), pp. 294-298.

Amines Role: RCT (Reactant)

Schneider, W. and Hoyer, J. and Ehrenstein, W. and Haller, R. and Haensel, W. and Lehmann, K. and Roth, H. J. and Schönenberger, Helmut and Camerino, B. (1975) Amines. Method. Chim. 6, pp. 439-589.

Amines Role: USES (Uses) (effect on Schiff base redn. by activated aluminum) Reduction (of Schiff bases by activated aluminum

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. VI. Mechanism of the reduction of Schiff bases with activated aluminum in ethanol. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 268-276.

amino acid antagonists as

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), pp. 857-862.

Amino acids Role: BAC (Biological activity or effector

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

Amino acids Role: BIOL (Biological study) (antagonists

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), pp. 857-862.

Amino acids Role: SPN (Synthetic preparation)

Schönenberger, Helmut and Endres, W. (1976) Research on the mechanism of action of local anesthetics. Part 7: Synthesis of N-aminoacyl-2,6-dimethylaniline, - benzylamine and -2-phenylethylamine enantiomers. Pharmazie 31 (1), pp. 30-32.

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

amino acyl-tRNA synthetase inhibition in relation to) Escherichia coli (benzylamines inhibition of growth and amino acyl-tRNA synthetases of) Mycobacterium tuberculosis (benzylamines inhibition of

Laske, Reiner and Meindl, Wolfgang and Holler, Eggehard and Schönenberger, Helmut (1989) Investigations on the mode of action of antimycobacterial benzylamines. Archiv der Pharmazie 322 (5), pp. 297-299.

aminoacryldimethylaniline derivs. binding to) Isomerism and Isomers (stereo-

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

aminoacryldimethylaniline derivs. in relation to) Membranes (protein

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

aminoacyl tRNA synthetase inhibition in relation to) amino acid antagonist antiproliferation tRNA synthetase

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), pp. 857-862.

aminoacyl tRNA synthetase inhibitory and antileukemic activities of) Neoplasm inhibitors (leukemia

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part II. The antileukemic effect. Archiv der Pharmazie 322 (12), pp. 857-862.

aminoacyl-tRNA synthetase targeting in) amino acid antagonist aminoacyl synthetase synthetase antitumor amino acid antagonist

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1991) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments. Archiv der Pharmazie 324 (3), pp. 153-160.

aminoalkylating compds. as)

Schönenberger, Helmut and Adam, A. (1964) The carcinostatic effects of amino alkylating compounds. I. Cytostatic compounds. Arzneimittel-Forschung = Drug research 14 (10), p. 1168.

aminoarylpropylene estradiol receptor inactivity propylene aminoaryl estradiol

Ball, Hartwig and Schneider, Martin R. and Schönenberger, Helmut (1984) 1-(Dimethylamino)-2,3,3-triphenylprop-1-enes: synthesis and affinity with estradiol receptor. Archiv der Pharmazie 317 (6), pp. 565-571.

aminomethylating compds. as)

Schönenberger, Helmut and Adam, A. and Adam, D. (1966) The action of aminomethylating carcinostatics on experimental tumors. IV. Cytostatic agents. Arzneimittel-Forschung = Drug research 16 (6), pp. 734-738.

aminomethylating substances as)

Schönenberger, Helmut and Adam, Adelheid (1965) Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics. Arzneimittel-Forschung = Drug research 15 (1), pp. 30-36.

Aminomethylation (by cancer-inhibiting substances) Cancer (inhibitors of

Schönenberger, Helmut and Adam, Adelheid (1965) Chemistry and mode of action of aminomethylating carcinostatics. II. Cytostatics. Arzneimittel-Forschung = Drug research 15 (1), pp. 30-36.

amphetamine anesthetics

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

analysis *Breast Neoplasms: DT

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

analysis *Tamoxifen: AD

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

and -diepoxyhexene

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, Hans P. (1982) Syntheses and evaluation of the potentially estrophilic cytostatics. 2,3-Epoxy-3,4-bis(4'-acetoxyphenyl)-4-hexene and 2,3,4,5-bisepoxy-3,4-bis(4'-acetoxyphenyl)hexane. Archiv der Pharmazie 315 (6), pp. 515-519.

and Antiseptics (synergistic

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Antitumor agents (mammary gland prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Mammary gland (neoplasm

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

and antitumor activity against human MCF-7 breast cancer of fluorophenyl ethylenediamine dicarboxylato Pt complexes) Solubility (water soly. of platinum fluorophenylethylenediamine dicarboxylato complexes) fluorophenylethylenediamine dicarboxylato platinum complex prepn antitumor activity platinum fluorophenylethylenediamine dicarboxylato complex soly fluorophenylethylenediamine dicarboxylato platinum complex nucleophilic substitution kinetics fluorophenylethylenediamine dicarboxylatoplatinum complex

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

and antitumor activity of parenterally administrable hydrosol of [bis(fluorophenyl)ethylenediamine]dichloroplatinum(II)

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyp Estrogen receptors Role: BSU (Biological study

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Estrogens Role: BAC (Biological activity or effector

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Molecular structure-biological activity relationship (estrogen receptor-binding

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) platinum chloro hydroxyphenylethylenediamine estrogen receptor binding ethylenediamine deriv platinum complex estrogen activity

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

and estrogenic activity of diastereomeric platinum(II) chloro bis(dichlorohydroxyphenyl)ethylenediamine complexes) Receptors Role: BSU (Biological study

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Anesthetics (3-[(3-hydroxy-1-methylpropyl)amino]butyric acid derivs. as local)

Schönenberger, Helmut and Vogel, H. and Bamann, E. (1965) Synthesis of local anesthetics. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (6), pp. 371-378.

Anesthetics (aminoacyl 2

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1968) Enantiomeric local anesthetics of the N-aminoacyl-2,6-dimethylaniline type. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 301 (10), pp. 780-785.

Anesthetics (ar-alkoxy-N-alkyl-alpha -phenylbenzylamines as) Schiff bases Role: RCT (Reactant)

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1966) Synthesis of alkoxybenzhydryl akylamines, local anesthetics from Schiff bases and phenyllithium. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 299 (12), pp. 1031-1038.

Anesthetics (cinchocaine homologs as local) cinchocaine homologs anesthetic activity anesthetic activity cinchocaine homologs dibucaine analogs anesthetics Nupercaine analogs anesthetics

Petter, Alfred and Schönenberger, Helmut and Zwez, W. (1970) Mode of local anesthetic activity of cinchocaine homologs. Arzneimittel-Forschung = Drug research 20 (10), pp. 1538-1542.

Anesthetics (local

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 1. Theories of action, questions, and means of solution. Pharmazie 27 (4), pp. 246-250.

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 2. Demonstration of the differential effect of enantiomeric local anesthetics. Pharmazie 27 (4), pp. 250-255.

Anesthetics (local) Psychotherapeutic agents (parasympatholytic activity of) Parasympatholytic substances (psychotherapeutic agents as) Psychotomimetic agents (review on)

Brinkmann, R. and Schönenberger, Helmut (1965) The mechanism of action of local anesthetics. Pharmazeutische Zeitung 110 (2), pp. 40-44.

Anesthetics (N-aminoacyl ephedrine isomers as local) Molecular structure-biological activity relationships (androgen-inhibiting

Brinkmann, Rolf and Schönenberger, Helmut and Petter, Alfred and Fuchsberger, K. D. and Zwez, W. (1967) Chemistry and local anesthetic effect of stereoisomeric N-aminoacyl ephedrines. Pharmaceutica acta Helvetiae 42 (8-10), pp. 576-592.

Anesthetics (N-aminoacylephedrine derivs. as local) Nerves (blocking agents for

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

Anesthetics (N-aminoacylephedrines as) AMINOACYLEPHEDRINES ANESTHETICS EPHEDRINES EPHEDRINES ANESTHETICS

Schönenberger, Helmut and Sieckmann, W. and Brinkmann, Rolf (1967) Effects of N-aminoacylephedrines, a new class of local anesthetics. Synthesis of local anesthetics with pressor activity. Arzneimittel-Forschung = Drug research 17 (6), pp. 744-747.

Anesthetics (pharmacology of local) anesthetics mechanism review review mechanism anesthetics

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1968) Mode of action of local anesthetics. Mitteilungen der Deutschen Pharmazeutischen Gesellschaft und der Pharmazeutischen Gesellschaft in der DDR 38 (11), pp. 209-221.

Anesthetics (piperidinomethylbenzamide derivs. as local) piperidinomethylbenzamides local anesthetics local anesthetics anesthetics local benzamides local anesthetics

Schönenberger, Helmut and Bindl, L. and Petter, A. and Zwez, W. (1970) Synthesis and local anesthetic action of N-(piperidinomethyl)-4-alkoxybenzamides. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 303 (10), pp. 798-804.

ANESTHETICS BENZHYDRYLAMINES BENZHYDRYLAMINES ANESTHETICS

Thies, Heinrich and Schönenberger, Helmut (1967) Alkoxybenzhydrylalkylamines and their acid addition salts.

Animal tissue culture (diamine ligand release from cisplatin analog in) diamine ligand release cisplatin analog cell

Bednarski, Patrick J. and Truembach, Barbara and Kratochwil, Nicole A. and Schönenberger, Helmut (1992) Diamine ligand release from the cisplatin analog [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) in cell culture medium. Journal of medicinal chemistry 35 (23), pp. 4479-4485.

Animals *Antineoplastic Agents Binding

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Animals *Antineoplastic Agents Cell Division: DE

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

Animals *Antineoplastic Agents: PD

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

anpirtoline carbon 14 piperidinethiol substitution chloropyridine carbon labeled

Engel, Juergen and Bork, Angelika and Nubert, Ingomar and Schönenberger, Helmut (1988) Synthesis of carbon-14-labeled anpirtoline. Archiv der Pharmazie 321 (11), pp. 821-822.

antagonists of

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1991) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments. Archiv der Pharmazie 324 (3), pp. 153-160.

antibacterial activity of) Escherichia coli (inhibition of

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

Antibiotics (amino acid antagonists

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

Antidepressants (phenylalanylphenylalkylamine derivs. as

Beck, D. and Fink, K. and Hoelzl, J. and Krieglstein, J. and Petter, A. and Rieger, H. and Schönenberger, Helmut (1983) Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class. Arzneimittel-Forschung = Drug research 33 (3), pp. 404-410.

Antidepressants (phenylalanylphenylalkylamines) Molecular structure-biological activity relationship (antidepressant

Schönenberger, Helmut and Petter, A. and Beck, D. and Endres, W. and Servatius, H. J. (1976) Studies on the mechanisms of action of local anesthetics. Part 9. N-Aminoacyl-beta -phenylalkylamine studies for the development of antidepressants from psychostimulants. Pharmazie 31 (12), pp. 882-886.

antiestrogen and estrogen inhibition of

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

antiestrogenic activity of) diphenylpyridylbutene estrogen pyridylbutene deriv antiestrogen antitumor butene deriv antiestrogen antitumor

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

antiestrogenic and estrogenic activity in relation to) Estrogens Role: BIOL (Biological study) (neoplasm inhibition by bis(hydroxyphenyl)hexane in relation to) hydroxyphenylhexane antitumor mechanism

Hartmann, R. W. and Schönenberger, Helmut and Wrobel, K. H. (1982) 3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat. Journal of cancer research and clinical oncology 103 (3), pp. 241-254.

antiestrogens inhibition of

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

antiestrogens inhibition of) Animal cell (MCF-7

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

antiestrogens inhibition of) antiestrogen mammary carcinoma DMBA breast cancer antiestrogen estrogen antagonist mammary tumor

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Antihypertensives (norfenefrine azomethines) Ring closure and formation (oxazolidines from norfenefrine and aldehydes and ketones) antihypotensive norfenefrine azomethine hypertensive norfenefrine azomethine oxazolidine hydroxyphenyl cyclization norfenefrine aldehyde ketone condensation norfenefrine aldehyde ketone

Schönenberger, Helmut and Petter, A. and Kühling, V. (1975) Azomethines and oxazolidines of norfenefrine. Development of compounds with long-lasting blood pressure raising activity. Archiv der Pharmazie 308 (9), pp. 717-719.

antimycobacteria compd. testing in relation to) Antibiotics (mycobacteria susceptibility to

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

antimycobacterial compd. testing in relation to) Culture media (for mycobacteria

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

antimycotic activity of

Schönenberger, Helmut and Kroetsch, Ulrich and Seidenberger, H. (1975) Mechanism of action of antimycotic beta -aminoketones. Deutsche Apotheker-Zeitung 115 (34), pp. 1244-1248.

Antineoplastic Combined Chemotherapy Protocols: PD

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

Antitumor Humans Leukemia P388: PA

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

antitumor activity in relation to) Estrogens Role: BIOL (Biological study) (receptors for

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

antitumor activity in relation to) Molecular structure-biological activity relationship (estrogen receptor-binding

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

antitumor activity in relation to) Neoplasm inhibitors (carcinoma

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

antitumor activity in relation to) platinum complex nucleic acid metab antitumor platinum complex nucleic acid

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

antitumor activity in relation to) Receptors Role: BIOL (Biological study) (for estrogens

Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

antitumor activity of

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1991) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments. Archiv der Pharmazie 324 (3), pp. 153-160.

antitumor activity of) Neoplasm inhibitors (diphenylpyridylbutenes as

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

antitumor activity platinum chloro aminoethoxyestrone aminoethoxyestradiol

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

antitumor activity platinum fluorophenylethylenediamine complex platinum fluorophenylethylenediamine diastereoisomer complex ethylenediamine fluorophenyl platinum diastereoisomer complex

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Antitumor agent resistance Antitumor agent resistance Complexation Mammary gland Prostate gland (optimization of cisplatin for treatment of hormone dependent tumoral diseases) DNA Estrogen receptors Role: BSU (Biological study

Gust, Ronald and Beck, Wolfgang and Jaouen, Gerard and Schönenberger, Helmut (2009) Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part.1. Use of steroidal ligands. Coordination Chemistry Reviews 253 (21-22), pp. 2742-2759.

Antitumor agent resistance Antitumor agent resistance Drug design Mammary gland Prostate gland (optimization of cisplatin for treatment of hormone-dependent tumoral diseases) review cisplatin complex hormone dependent tumor antitumor resistance

Gust, Ronald and Beck, Wolfgang and Jaouen, Gerard and Schönenberger, Helmut (2009) Optimization of cisplatin for the treatment of hormone-dependent tumoral diseases Part.2 Use of non-steroidal ligands. Coordination chemistry reviews 253 (21-22), pp. 2760-2779.

Antitumor agents ([rac-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

antitumor effect)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

antitumor mechanism in relation to) Deoxyribonucleic acids Role: BIOL (Biological study) (template activity of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

antitumor mechanism in relation to) Nucleic acids Role: BPR (Biological process)

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

antitumor platinum compds. effect on

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

app. for)

Schönenberger, Helmut and Eder, Maximilian and Bamann, Eugen (1964) Separation of organic bases by Craig distribution. III. Development of a partition machine with variable lower phase volume and its use in the separation of amine mixtures. Fresenius' Zeitschrift für analytische Chemie 202 (1), pp. 1-6.

attempted) Neoplasm inhibitors (bis(2-chloroethyl)aminomethyl amides) benzamide bischloroethylaminomethyl carcinostatic chloroethylaminomethylbenzamide carcinostatic sarcoma chloroethylaminomethylbenzamide acetamide trichloro carcinostatic

Schönenberger, Helmut and Bindl, L. and Adam, A. (1973) Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides. Archiv der Pharmazie 306 (1), pp. 64-75.

Bactericidal action and Bacteriostatic action (of beta -aminoketones) Ketones Role: BIOL (Biological study) (beta -amino-

Schönenberger, Helmut and Kroetsch, Ulrich and Seidenberger, H. (1975) Mechanism of action of antimycotic beta -aminoketones. Deutsche Apotheker-Zeitung 115 (34), pp. 1244-1248.

Bactericides

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.

Schönenberger, Helmut and Lippert, P. (1972) Cytostatics. 16. Antimicrobial and tumor-inhibiting properties of dithiourethane and studies on the mechanism of action. Pharmazie 27 (3), pp. 139-145.

Schönenberger, Helmut and Adam, D. and Alonso, G. and Adam, A. (1972) Cytostatics. 17. The antimicrobial and antitumor activity of Mannich bases of 3,3'- and 4,4'-dihydroxy-alpha ,beta -diethylstilbene. Archiv der Pharmazie 305 (4), pp. 300-308.

Schönenberger, Helmut and Holzheu-Eckardt, Juergen and Bamann, Eugen and Mehnert, Brigitte (1963) Chemical constitution and bacteriostatic activity of isomeric hydroxybenzamides. II. Antimycotic substances. Arzneimittel-Forschung = Drug research 13, pp. 936-939.

Bactericides Fungicides (amino ketones) Ketones Role: BIOL (Biological study) (amino

Schönenberger, Helmut and Bastug, T. (1970) Cytostatic agents. 9. Relations between physicochemical properties and antimicrobial activity of beta -amino ketones. Arzneimittel-Forschung = Drug research 20 (3), pp. 386-390.

benign hyperplasia

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

benzylamine-contg. compns.

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

benzylamine-contg. synergistic bactericides for) Bactericides

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

between hydrochloric acid solns. and org. phase) Craig distribution alkylbenzylamines distribution Craig alkylbenzylamines alkylbenzylamines Craig distribution amines alkylbenzyl distribution benzylalkylamines distribution sepn alkylbenzylamines

Schönenberger, Helmut and Eder, Maxcimilian (1970) Separation of organic bases by Craig distribution. VIII. Separation of N-alkylbenzylamine mixtures by multiplicative distribution. Fresenius' Zeitschrift für analytische Chemie 249 (2), pp. 117-120.

biocidal action of

Schönenberger, Helmut and Bastug, T. and Bindl, L. and Adam, Adelheid and Adam, Dieter and Petter, A. and Zwez, W. (1969) Action mechanism of antimicrobial beta -amino ketones. Pharmaceutica acta Helvetiae 44 (11), pp. 691-714.

BIOL (Biological study)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

BIOL (Biological study) (alkyl esters

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

BIOL (Biological study) (antimicrobial activity of

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

BIOL (Biological study) (antimicrobial activity of) Molecular structure-biological activity relationships (antimicrobial

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

BIOL (Biological study) (diphenylpyridylbutenes as inhibitors of

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

BIOL (Biological study) (estrogen

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

BIOL (Biological study) (inhibitors

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

BIOL (Biological study) (optimization of cisplatin for treatment of hormone dependent tumoral diseases) review cisplatin carboplatin breast prostate cancer antitumor resistance

Gust, Ronald and Beck, Wolfgang and Jaouen, Gerard and Schönenberger, Helmut (2009) Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part.1. Use of steroidal ligands. Coordination Chemistry Reviews 253 (21-22), pp. 2742-2759.

BIOL (Biological study) (prepn.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

BIOL (Biological study) (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) platinum chloro fluorohydroxyphenylethylenediamine prepn antitumor breast cancer

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

BIOL (Biological study) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Receptors Role: BPR (Biological process)

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

biological response modifiers

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

bis(acetoxyphenyl)phenylbutenes as) styrylphenyl acetate prepn antitumor antiestrogenic styrylphenylacetate prepn

Schneider, Martin R. and Ball, Hartwig and Schönenberger, Helmut (1985) Acetoxy-substituted 1,1,2-triphenylbut-1-enes with antiestrogenic and mammary tumor inhibiting properties. Journal of medicinal chemistry 28 (12), pp. 1880-1885.

bis(fluorohydroxyphenyl)dimethylbutane derivs.) bisfluorohydroxyphenyldimethylbutane deriv prepn antiestrogen activity estrogen inhibitor fluorohydroxyphenyldimethylbutane deriv

Schwarz, Walter and Hartmann, Rolf W. and Engel, Juergen and Schneider, Martin R. and Schönenberger, Helmut (1990) Cytotoxic ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Archiv der Pharmazie 323 (2), pp. 121-124.

bis(hydroxymethylphenyl)butane inhibition of) antiestrogen butestrol metabutestrol prepn estrogen receptor binding butestrol metabutestrol antitumor butanebis hydroxymethylphenyl structure activity butestrol metabutestrol antiestrogen

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

bis(hydroxyphenyl)alkanes) mammary tumor inhibitor hydroxyphenylalkane prepn uterotropic hydroxyphenylalkane antiuterotropic hydroxyphenylalkane Grignard benzaldehyde chloromethoxyphenylalkane Grignard

Schönenberger, Helmut and Kranzfelder, Gerhard and Schmitt-Wallenborn, Helga (1978) Bis(3-hydroxyphenyl)alkane compounds.

bis(hydroxyphenyl)phenylethene affinity for) Estrogens Role: BIOL (Biological study) (receptors

Gust, Ronald and Schönenberger, Helmut and Range, Klaus Juergen and Klement, Ulrich and Schneider, Martin (1993) Crystal structure and hormonal activity of 1,1-bis(4-hydroxyphenyl)-2-phenylethene. Monatshefte für Chemie 124 (11-12), pp. 1181-1193.

bis(hydroxyphenyl)phenylethene affinity for) hydroxyphenylphenylethene crystal structure antiestrogen estrogen activity

Gust, Ronald and Schönenberger, Helmut and Range, Klaus Juergen and Klement, Ulrich and Schneider, Martin (1993) Crystal structure and hormonal activity of 1,1-bis(4-hydroxyphenyl)-2-phenylethene. Monatshefte für Chemie 124 (11-12), pp. 1181-1193.

bis(hydroxyphenyl)phenylethene as) Receptors Role: BIOL (Biological study) (estrogen

Gust, Ronald and Schönenberger, Helmut and Range, Klaus Juergen and Klement, Ulrich and Schneider, Martin (1993) Crystal structure and hormonal activity of 1,1-bis(4-hydroxyphenyl)-2-phenylethene. Monatshefte für Chemie 124 (11-12), pp. 1181-1193.

biscycloalkylamineplatinum dichloro antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

BPR (Biological process)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

BSU (Biological study

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

butestrols and metabutestrols as) Neoplasm inhibitors (bis(hydroxymethylphenyl)butane as

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

butestrols and metabutestrols binding by) Molecular structure-biological activity relationship (antiestrogenic

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

by [bis(hydroxyphenyl)ethylendiamine]dichloroplatinum(II)

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

by Al

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1965) Effect of solvents on the reduction between Schiff bases and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (9), pp. 635-638.

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1965) Effect of solvents on the reduction between Schiff bases and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (9), pp. 635-638.

by amino acid antagonist targeting for aminoacyl-tRNA synthetases) Molecular structure-biological activity relationship (bactericidal

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

by benzylamine

Dhople, A. M. and Strong, L. C. and Meindl, W. and Schönenberger, Helmut and Gardner, G. D. (1991) In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae. Arzneimittel-Forschung = Drug research 41 (3), pp. 253-256.

by benzylamine-contg. synergistic bactericidal compns.) Leprosy Tuberculosis (treatment of

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

by countercurrent partition)

Schönenberger, Helmut and Brinkman, R. and Bamann, E. (1963) Resolution of N-(DL-N,N-dimethylalanyl)-L-y-ephedrine into its stereoisomeric forms of Craig partition. The possibility of resolution of racemic amino acids into optical isomers using countercurrent methods. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 33-37.

by countercurrent partition) Amino acids (resolution of

Schönenberger, Helmut and Brinkman, R. and Bamann, E. (1963) Resolution of N-(DL-N,N-dimethylalanyl)-L-y-ephedrine into its stereoisomeric forms of Craig partition. The possibility of resolution of racemic amino acids into optical isomers using countercurrent methods. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 33-37.

by Craig partition) AMPHETAMINES SEPN PERVITAMINES SEPN EPHEDRINES SEPN

Schönenberger, Helmut and Brinkmann, Rolf (1966) Separation of organic bases by Craig partition. VI. Correlations between the configuration and the phase distribution behavior of aminoacylephedrines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 229 (11), pp. 952-965.

by endocrine-active platinum complex) hormone dependent prostate tumor platinum complex endocrine active platinum complex prostate tumor mammary tumor endocrine active platinum complex

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

by endocrine-active platinum complex) Mammary gland (neoplasm

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

by Grignard reagents in presence of CoCl2) Schiff bases (redn. of

Schönenberger, Helmut and Thies, Heinrich and Zeller, A. (1961) The reduction of Schiff bases by Grignard reagents with the addition of cobaltous chloride. Naturwissenschaften 48, p. 303.

by Grignard reagents in presence of CoCl2) Unsaturated compounds (spectra and structure of)

Schönenberger, Helmut and Thies, Heinrich and Zeller, A. (1961) The reduction of Schiff bases by Grignard reagents with the addition of cobaltous chloride. Naturwissenschaften 48, p. 303.

by neoplasm

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

by neutron activation anal.) Organ (platinum of antitumor drugs detn. in

Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.

by neutron activation anal.) Radiochemical analysis (neutron activation

Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.

by platinum compds.) dichlorohydroxyphenylethylenediaminedichlorplatinum antitumor prostate platinum compd antitumor prostate

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

by platinum complexes of diaminoethanes) Neoplasm inhibitors (carcinoma

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

by substitution reactions of N-carbethoxyphthalimide

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

by tetramethylbis(hydroxyphenyl)ethanes) Molecular structure-biological activity relationship (neoplasm-inhibiting

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

by tumor

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

carbon 14 D16726 indole ethyl carbon 14

Engel, Juergen and Bork, Angelika and Von Angerer, Erwin and Schönenberger, Helmut (1984) Carbon-14 labeling of D 16726, a structurally unique antiestrogen. Chemiker-Zeitung 108 (12), pp. 407-408.

carboplatin deriv anticancer

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

carcinoma

Müller, Richard and Bednarski, Patrick J. and Schönenberger, Helmut (1992) (1,2-Diaryl-1,2-ethylenediamine)platinum(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with different types of coordination in the solid state, in solution and reactions with nucleophiles. Inorganica chimica acta 195 (1), pp. 77-87.

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

Carcinoma (inhibitors of

Schönenberger, Helmut and Adam, A. (1964) The carcinostatic effects of amino alkylating compounds. I. Cytostatic compounds. Arzneimittel-Forschung = Drug research 14 (10), p. 1168.

Carcinoma (of mammary gland

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

chain branching in relation to) Chains (branching of

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

chain length in relation to) aminonitriles Grignards reaction Grignards aminonitriles reaction nitriles amino Grignards reaction piperidine nitriles Grignards

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

chemical synthesis *Estrogen Antagonists: PD

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

chemoreceptors and) Hydrocinnamamide Role: BAC (Biological activity or effector

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

chemosensitivity human melanoma cell cytostatic

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion)

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

chemotherapy of) Carcinoma (of mammary gland

Schönenberger, Helmut and Kranzfelder, G. and Hoffmann, E. and Egginger, G. and Schmitt, H. and Taneja, A. K. (1976) Experimental chemotherapy of the breast cancer. Die Pharmazie 31 (9), pp. 590-597.

chemotherapy of) review chemotherapy mastocarcinoma breast cancer chemotherapy review

Schönenberger, Helmut and Kranzfelder, G. and Hoffmann, E. and Egginger, G. and Schmitt, H. and Taneja, A. K. (1976) Experimental chemotherapy of the breast cancer. Die Pharmazie 31 (9), pp. 590-597.

cinchocaine homologs as) review anesthetic lipid soly cinchocaine anesthetic soly review

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics. Pharmazie 27 (8), pp. 522-523.

Circulation Heart ((methoxybenzamidomethyl)norephedrine and related compds. effect on) cardiovascular catechol amine deriv heart catechol amine deriv circulation catechol amine deriv blood pressure catechol amine deriv norephedrine analog heart circulation

Schönenberger, Helmut and Petter, Alfred and Kuehling, Volker and Bindl, Ludwig (1976) Synthesis and testing the cardiocirculatory effects of N-(3'-methoxybenzamidomethyl)-D-norephedrine and analogous compounds. Archiv der Pharmazie 309 (4), pp. 289-301.

Circulation (N-aminoacyl ephedrine derivs. effect on heart) Nerves (blocking agents for

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1967) Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type. Pharmaceutica acta Helvetiae 42 (8-10), pp. 593-603.

cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of estrogens interaction with

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum interaction with

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

cisplatin derivs. as

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

cisplatin derivs. for) carcinoma mammary cisplatin review cisplatin antitumor platinum complex antitumor

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

Competitive Estrogen Antagonists: CS

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Configuration Conformation and Conformers (prepn.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Configuration (of dialkyldiphenylethylenediamines and -imidazolidine derivs.) NMR ethylenediamine imidazolidine diphenyl NMR configuration diphenylethylenediamine

Schönenberger, R. and Sunkel, C. and Schönenberger, Helmut (1972) Cytostatics. 19. Configurative assignment of diastereomer N,N'-dialkyl-alpha ,alpha '-diphenylethylenediamines by nuclear resonance spectroscopy. Arzneimittel-Forschung = Drug research 22 (11), pp. 1952-1955.

Conformation Stereochemistry (antitumor potency of diastereomeric and enantiomeric platinum diaminophenylpropane dichloro complexes in relation to) Structure-activity relationship (antitumor stereoselectivity of antitumor active [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Conformation (of N

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

Conformation and Conformers (of hydroxyphenylethylenediamine sulfatoplatinum complexes) Molecular structure-biological activity relationship (estrogenic

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

Conformation and Conformers (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Estrogen receptors Role: BPR (Biological process)

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Conformers EHMO Hydrolysis Isomerization Molecular mechanics Molecular structure Total energy Transition state structure (mol.-mech. and quantum chem. study of species involved in hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes) Amines Role: PEP (Physical

Nikolov, G. S. and Trendafilova, N. and Georgieva, I. and Schönenberger, Helmut and Gust, R. and Kritzenberger, J. and Yersin, H. (1997) Molecular mechanical and quantum chemical study of the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes. Part 2. Simulated transition states. Monatshefte für Chemie 128 (5), pp. 443-474.

Cope rearrangement (of bis(hydroxyphenyl)ethylenediamine reaction products with fluorobenzaldehyde)

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Craig

Schönenberger, Helmut and Eder, Maximilian and Bamann, Eugen (1964) Separation of organic bases by Craig distribution. III. Development of a partition machine with variable lower phase volume and its use in the separation of amine mixtures. Fresenius' Zeitschrift für analytische Chemie 202 (1), pp. 1-6.

Craig distribution in) sepn amines Craig distribution amines sepn Craig distribution Craig distribution sepn amines distribution Craig sepn amines

Schönenberger, Helmut and Thies, Heinrich and Borah, Kripanath (1970) Quantitative determination of amine mixtures by multiplicative distribution. IX. Separation of organic bases by Craig distribution. Fresenius' Zeitschrift für analytische Chemie 251 (5), pp. 294-298.

Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethane) mol structure chloromethoxyphenyl ethane

Klement, U. and Range, K. J. and Gust, R. and Schönenberger, Helmut (1996) Crystal structure of 1-(2-chloro-5-methoxyphenyl)-2-(2,6-dichloro-4-methoxyphenyl)ethane, (CH3O)(C6H3Cl)(CH2)2(C6H2Cl2)(OCH3). Zeitschrift für Kristallographie 211 (11), p. 851.

Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethane) mol structure chloromethoxyphenylethane ethane chloromethoxyphenyl structure

Klement, U. and Range, K. J. and Gust, R. and Schönenberger, Helmut (1996) Crystal structure of 1-(2-chloro-4-methoxyphenyl)-2-(2,6-dichloro-4-methoxyphenyl)ethane, (CH3O)(C6H3Cl)(CH2)2(C6H2Cl2)(OCH3). Zeitschrift für Kristallographie 211 (11), p. 853.

Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethene) mol structure chloromethoxyphenylethane ethane chloromethoxyphenyl structure crystal structure chloromethoxyphenylethane

Klement, Ulrich and Range, K. J. and Gust, Ronald and Schönenberger, Helmut (1996) Crystal structure of (Z)-[1-(2-chloro-5-methoxyphenyl)-2-(2,6-dichloro-4-methoxyphenyl)ethene], (CH3O)(C6H2Cl2)(CH)2(C6H3Cl)(OCH3). Zeitschrift für Kristallographie 211 (11), p. 850.

Crystal structure Molecular structure (of (chloromethoxyphenyl)(dichloromethoxyphenyl)ethene) mol structure chloromethoxyphenylethene crystal structure chloromethoxyphenylethene ethene chloromethoxyphenyl structure

Klement, U. and Range, K. J. and Gust, R. and Schönenberger, Helmut (1996) Crystal structure of (E)-[1-(2-chloro-5-methoxyphenyl)-2-(2,6-dichloro-4-methoxyphenyl)ethene], (CH3O)(C6H2Cl2)(CH)2(C6H3Cl)(OCH3). Zeitschrift für Kristallographie 211 (11), p. 854.

Crystal structure Molecular structure (of diazido(methoxyphenyl)phenylethane) crystal structure azidohydroxyphenylethylenediamine platinum hydroxyphenylethylinediamine complex ethylenediamine hydroxyphenyl platinum complex azidohydroxyphenylethylenediamine prepn structure

Müller, Richard and Gust, Ronald and Klement, Ulrich and Schönenberger, Helmut (1991) Stereoisomeric dichloro[1-(hydroxyphenyl)-2-phenyl-1,2-ethanediamine]platinum(II) complexes. I. Synthesis. Chemische Berichte 124 (11), pp. 2381-2389.

Crystal structure Molecular structure (of platinum hydroxyphenylethylenediamine diastereomeric complexes) Substitution reaction (of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Kinetics of substitution reaction (coordinative

Gust, Ronald and Schönenberger, Helmut and Kritzenberger, Juergen and Range, Klaus Juergen and Klement, Ulrich and Burgemeister, Thomas (1993) Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Inorganic chemistry 32 (26), pp. 5939-5950.

culture media influence in) Albumins Ovalbumins Role: BIOL (Biological study) (culture media contg.

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

culture media influence in) mycobacteria antibiotic test culture media albumin antimycobacteria compd test

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

Cultured: DE

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

Krischke, W. and Hartmann, R. and Schneider, M. and Schönenberger, Helmut (1988) A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay. Journal of cancer research and clinical oncology 114 (2), pp. 170-176.

D16427 carbon 14 labeled phenol araliph amino labeled

Engel, Juergen and Bickel, Erich and Klingler, Karl Heinz and Schönenberger, Helmut (1986) Carbon-14 labeling of D 16 427, a new positive inotropic compound. Archiv der Pharmazie 319 (12), pp. 1113-1116.

dapsone and rifampicin enhancement of) benzylamine Mycobacterium inhibition dapsone rifampicin leprosy treatment benzylamine ME93 Mycobacterium inhibition

Dhople, A. M. and Strong, L. C. and Meindl, W. and Schönenberger, Helmut and Gardner, G. D. (1991) In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae. Arzneimittel-Forschung = Drug research 41 (3), pp. 253-256.

Deoxyribonucleic acid formation (by neoplasm

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

Deoxyribonucleic acid formation (inhibition of

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

Deoxyribonucleic acids Role: BPR (Biological process)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

DES catechol analog interaction in) Carcinoma (of mammary gland

Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.

DES catechol analogs inhibition of) DES catechol analog prepn estrogen carcinoma mammary inhibition DES analog uterus growth DES catechol analog

Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.

DES catechol analogs inhibition of) Mammary gland (neoplasm

Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.

detn. of

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

dialkylbis(hydroxyphenyl)ethanes as) Molecular structure-biological activity relationship (antiestrogenic

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

dialkylbis(hydroxyphenyl)ethanes inhibition of) Estrogens Role: BSU (Biological study

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

dialkylbis(hydroxyphenyl)ethanes inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

dichlorobis(cycloalkylamine)platinum(II) complexes as

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

dichlorobiscycloalkylamineplatinum antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

dichlorodipeptide ester platinum complex inhibition of) peptide platinum complex neoplasm inhibitor

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

dichloroplatinum complexes

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

dihydroxy(trifluoropropyl)benzanilide) hydroxybenzanilide trifluoropropyl trifluoropropylbenzanilide prepn antiestrogen

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Heindl, Alexander and Schönenberger, Helmut (1988) N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide: synthesis and pharmacological evaluation of a new antiestrogen. Archiv der Pharmazie 321 (8), pp. 497-501.

Dimerization (of piperidineacetonitrile with tert-butylmagnesium chloride) nitriles aminodipiperidinocrotono crotononitriles amino piperidino piperidinocrotononitriles amino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. IV. Dimerization of alpha -piperidinoacetonitrile with tert-butylmagnesium chloride. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (3), pp. 161-168.

dimethylaniline and ephedrine enantiomers as) local anesthetic membrane protein nerve conduction anesthetic

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 2. Demonstration of the differential effect of enantiomeric local anesthetics. Pharmazie 27 (4), pp. 250-255.

Disinfectants

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (dithiourethanes) dithiourethane fungistatic antibacterial dithiourethane dithiocarbamate fungistatic

Schönenberger, Helmut and Lippert, P. (1972) Cytostatics. 16. Antimicrobial and tumor-inhibiting properties of dithiourethane and studies on the mechanism of action. Pharmazie 27 (3), pp. 139-145.

Disinfectants and Antiseptics Fungicides and Fungistats Neoplasm inhibitors (tris(hydroxymethyl) melamine derivs.) melamine deriv carcinostatic bacteriostatic fungistatic melamine deriv tumor inhibition alkylating triazine

Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1973) Cytostatics. 23. Tumor-inhibiting effect of N,N.',N"-tris(hydroxymethyl)melamine and analogous compounds. Archiv der Pharmazie 306 (4), pp. 274-284.

Disinfectants and Antiseptics Neoplasm inhibitors (dichlorodipeptide ester platinum complexes) Deoxyribonucleic acids Proteins Ribonucleic acids Role: FORM (Formation

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

Disinfectants and Antiseptics Neoplasm inhibitors (Mannich bases of dihydroxydiethylstilbenes) Mannich bases Role: BIOL (Biological study) (of dihydroxydiethylstilbenes) Mannich base stilbene antimicrobial antitumor antitumor Mannich base stilbene cytostatic Mannich base stilbene aminomethylstilbene cytostatic

Schönenberger, Helmut and Adam, D. and Alonso, G. and Adam, A. (1972) Cytostatics. 17. The antimicrobial and antitumor activity of Mannich bases of 3,3'- and 4,4'-dihydroxy-alpha ,beta -diethylstilbene. Archiv der Pharmazie 305 (4), pp. 300-308.

Disinfectants and Antiseptics (glycylglycine platinum complex) Neoplasm inhibitors (Walker 256 carcinosarcoma

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

Disinfectants and Antiseptics (hydroxybenzamide derivs. as) Staphylococcus (aureus (includes albus and citreus)

Schönenberger, Helmut and Holzheu-Eckardt, Juergen and Bamann, Eugen and Mehnert, Brigitte (1963) Chemical constitution and bacteriostatic activity of isomeric hydroxybenzamides. II. Antimycotic substances. Arzneimittel-Forschung = Drug research 13, pp. 936-939.

DNA formation ([Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

drug effects *Tumor Stem Cell Assay

Krischke, W. and Hartmann, R. and Schneider, M. and Schönenberger, Helmut (1988) A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay. Journal of cancer research and clinical oncology 114 (2), pp. 170-176.

drug effects 0 (Antineoplastic Agents) 0 (Estrogen Antagonists) 0 (Receptors

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

drug effects 0 (Receptors

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

drug effects Cell Line Leukemia L1210: DT

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

drug therapy *Organometallic Compounds: TU

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

drug therapy Breast Neoplasms: PA

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

drug therapy Mammary Neoplasms

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

drug therapy Mice *Neoplasms

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

effect of aluminum and mercury salts and of amines on) MECHANISMS REDN SCHIFF BASE SCHIFF BASE REDN MECHANISMS REDNS ACTIVATED ALUMINUM ALUMINUM ACTIVATED REDNS

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. VI. Mechanism of the reduction of Schiff bases with activated aluminum in ethanol. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 268-276.

effect of aluminum and mercury salts and of amines on) Schiff bases Role: PRP (Properties) (redn. by activated aluminum

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. VI. Mechanism of the reduction of Schiff bases with activated aluminum in ethanol. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 268-276.

Ehrlich Tumor: PA

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

elmustin carbon 14

Bickel, E. and Engel, Juergen and Oepen, G. and Von Angerer, Erwin and Schönenberger, Helmut (1985) Carbon-14 labeling of the cytostatic nitrosourea elmustin. Chemiker-Zeitung 109 (10), pp. 347-348.

endocrine-active platinum complex as

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

endocrine-active platinum complex effect on

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

engineering or chemical process)

Nikolov, G. S. and Trendafilova, N. and Georgieva, I. and Schönenberger, Helmut and Gust, R. and Kritzenberger, J. and Yersin, H. (1997) Molecular mechanical and quantum chemical study of the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes. Part 2. Simulated transition states. Monatshefte für Chemie 128 (5), pp. 443-474.

Escherichia coli (platinum complexes screening for neoplasm-inhibitory activity in) Neoplasm inhibitors (platinum-bis(oligopeptide ester) complexes as

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthard (1984) cis-Dichloro[bis(oligopeptide ester)]platinum(II) complexes, study on the detection of antitumor activity with bacteriological test systems. Archiv der Pharmazie 317 (9), pp. 760-767.

estradiol aminoethoxy platinum chloro

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

estradiol antagonism of) Mammary gland (neoplasm

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

estradiol receptor affinity

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Estradiol)

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Estradiol: DE

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

estrogen receptor affinity

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

estrogen receptors of

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Estrogen)

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

estrogen-dependent

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

Estrogen: AN

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

Estrogen: ME

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

estrogenic activity in

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

estrogenic activity in relation to) Mammary gland Prostate gland (neoplasm

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

estrogenic activity in relation to) Neoplasm inhibitors (prostate gland

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

estrogenic activity in relation to) phenylethylenediamine platinum complex estrogenic crystal structure conformation phenylethylenediamine platinum complex estrogenic activity mammary cancer inhibitor phenylethylenediamine platinum complex

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

estrogenic platinum(II) complex as) estrogenic platinum complex breast cancer inhibitor

Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.

estrogenic platinum(II) complex as) Mammary gland (neoplasm

Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.

estrogenic/antiestrogenic activity

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

estrogenicity in relation to) Molecular structure-biological activity relationship (estrogenic

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

Estrogens Role: BAC (Biological activity or effector

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

Estrogens Role: BIOL (Biological study) ([(hydroxyphenyl)ethylenediamine]platinum(II) complexes as

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

Estrogens Role: BIOL (Biological study) (and inhibitors

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

Estrogens Role: BIOL (Biological study) (bis(hydroxyphenyl)phenylethene as) Crystal structure (of bis(hydroxyphenyl)phenylethene) Estrogens Role: BIOL (Biological study) (antiestrogens

Gust, Ronald and Schönenberger, Helmut and Range, Klaus Juergen and Klement, Ulrich and Schneider, Martin (1993) Crystal structure and hormonal activity of 1,1-bis(4-hydroxyphenyl)-2-phenylethene. Monatshefte für Chemie 124 (11-12), pp. 1181-1193.

Estrogens Role: PRP (Properties) ((dichlorohydroxyphenyl)phenylethylenediamines and their platinum sulfato complexes) Neoplasm inhibitors (platinum complexes with (dichlorohydroxyphenyl)phenylethylenediamines) antitumor activity platinum phenylethylenediamine complex estrogenic property platinum phenylethyleneidamine complex amine phenylethylenedi platinum complex

Gust, Ronald and Burgemeister, Thomas and Mannschreck, Albrecht and Schönenberger, Helmut (1990) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine](sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring. 1. Synthesis and antitumor and estrogenic properties. Journal of medicinal chemistry 33 (9), pp. 2535-2544.

Estrogens Role: RCT (Reactant)

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

Estrogens Role: USES (Uses) (inhibitors

Schwarz, Walter and Hartmann, Rolf W. and Engel, Juergen and Schneider, Martin R. and Schönenberger, Helmut (1990) Cytotoxic ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Archiv der Pharmazie 323 (2), pp. 121-124.

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Heindl, Alexander and Schönenberger, Helmut (1988) N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide: synthesis and pharmacological evaluation of a new antiestrogen. Archiv der Pharmazie 321 (8), pp. 497-501.

estrone aminoethoxy platinum chloro

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

ethylenediamine deriv. in treatment of) cytostatic benzanthracene tumor ethylenediamine cytostat

Schönenberger, Helmut and Griebl, G. and Adam, D. and Adam, A. (1971) Effect of meso- and dl-N,N'-dibutyl-alpha,alpha-bis(3-chloro-4-methoxyphenyl)ethylenediamine on the mammary tumor in the Sprague-Dawley rat induced by 7,12-dimethylbenz[alpha]anthracene (DMBA). 14. Cytostatic compounds. Arzneimittel-Forschung = Drug research 21 (12), pp. 2104-2106.

ethylenediamine deriv. in treatment of) Neoplasm (of mammary gland

Schönenberger, Helmut and Griebl, G. and Adam, D. and Adam, A. (1971) Effect of meso- and dl-N,N'-dibutyl-alpha,alpha-bis(3-chloro-4-methoxyphenyl)ethylenediamine on the mammary tumor in the Sprague-Dawley rat induced by 7,12-dimethylbenz[alpha]anthracene (DMBA). 14. Cytostatic compounds. Arzneimittel-Forschung = Drug research 21 (12), pp. 2104-2106.

ethylenediamines diphenyl cytostatic cytostatic diphenylethylenediamines diphenylethylenediamines cytostatic diaminodiphenylethanes cytostatic amines araliph cytostatic anticancer ethylenediamines

Schönenberger, Helmut and Steinhoff, Dieter (1970) Cytostatic dl- and meso-1,2-diphenylethylenediamines.

except adverse)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

Experimental: DT

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

Experimental: ME

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Experimental: PA

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Experimental: PC

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

Extraction apparatus (distribution

Schönenberger, Helmut and Eder, Maximilian and Bamann, Eugen (1964) Separation of organic bases by Craig distribution. III. Development of a partition machine with variable lower phase volume and its use in the separation of amine mixtures. Fresenius' Zeitschrift für analytische Chemie 202 (1), pp. 1-6.

Fever and Hyperthermia (chemosensitivity of human melanoma cell lines and choice of cytostatics for hyperthermic isolated limb perfusion)

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

fluorophenyl ethylendiamine cyclobutane carboxylatoplatinum synthesis anticancer

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

fluorophenylethylenediaminedichloroplatinum complex prepn stability neoplasm inhibition

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

followed by amidation and redn.) platinate chloro substituted ethylenediamine antitumor activity platinate chloro substituted ethylenediamine amino acid esterification amination amino acid ester amide prepn redn

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

for amines) Amines Bases (extn. of

Schönenberger, Helmut and Eder, Maximilian and Bamann, Eugen (1964) Separation of organic bases by Craig distribution. III. Development of a partition machine with variable lower phase volume and its use in the separation of amine mixtures. Fresenius' Zeitschrift für analytische Chemie 202 (1), pp. 1-6.

for estrogen receptor-pos. tumors) Prostate gland (disease

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

for human mammary carcinoma) epoxidn hexadiene epoxyhexene mammary carcinoma inhibitor diepoxyhexane mammary carcinoma inhibitor mammary carcinoma inhibitor epoxide tritiated estradiol receptor inhibition epoxide

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, Hans P. (1982) Syntheses and evaluation of the potentially estrophilic cytostatics. 2,3-Epoxy-3,4-bis(4'-acetoxyphenyl)-4-hexene and 2,3,4,5-bisepoxy-3,4-bis(4'-acetoxyphenyl)hexane. Archiv der Pharmazie 315 (6), pp. 515-519.

for mammary gland) Mammary gland (neoplasm

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

for mammary tumors) Amines Role: SPN (Synthetic preparation)

Gust, Ronald and Schönenberger, Helmut (1993) Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. European journal of medicinal chemistry 28 (2), pp. 103-115.

for mammary tumors) Estrogens Role: RCT (Reactant)

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

FORM (Formation

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

from DMBA

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

fungicidal activity and partition coeffs. and soly. of) Partition (of amino ketones) cytostatic agent antibacteria agent antifungal compd bacteriostatic compd beta amino ketone fungistats

Schönenberger, Helmut and Bastug, T. (1970) Cytostatic agents. 9. Relations between physicochemical properties and antimicrobial activity of beta -amino ketones. Arzneimittel-Forschung = Drug research 20 (3), pp. 386-390.

Fungicides and Fungistats Neoplasm inhibitors (dithiocarbamic acid derivs.) aminal carcinostatic fungistatic thiocarbamate deriv carcinostatic fungistatic acetal carcinostatic fungistatic antitumor carbamate deriv

Schönenberger, Helmut and Lippert, P. (1972) Cytostatics. 18. Carcinostatic and antimicrobial activity of acylated N-hemiacetals, aminals, and aminomethyl esters of dithiocarbamic acid. Archiv der Pharmazie 305 (6), pp. 427-441.

Fungicides or Fungistats (diethylstilbestrol) Bactericidal action or Bacteriostatic action (of alpha

Schönenberger, Helmut and Adam, Dieter (1966) The cytostatic effect of isomeric diethylstilbestrols. IV. Antimycotics. Arzneimittel-Forschung = Drug research 16 (6), pp. 738-740.

Fungicides or Fungistats (hydroxyaryl amides as) Benzamide Benzamide Role: PREP (Preparation)

Schönenberger, Helmut and Holzheu-Eckardt, Juergen and Bamann, Eugen (1964) Antimycotics. III. Comparative studies of the preparation of isomeric hydroxybenzamides. Arzneimittel-Forschung = Drug research 14 (4), pp. 324-328.

glycylglycine Et ester platinum complex effect on

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

glycylglycine platinum complex) Neoplasm inhibitors (sarcoma 180

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

glycylglycine platinum complex) Neoplasm inhibitors (yoshidasarcoma

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

glycylglycine platinum complex) peptide platinum chloride complex bactericide glycylglycine platinum complex carcinostat glycylglycine platinum complex

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst (1977) cis-Dichloropeptide ester-platinum(II) complexes.

Grignard reaction (in Schiff base redn. in presence of CoCl2) Reduction (of Schiff bases

Schönenberger, Helmut and Thies, Heinrich and Zeller, A. (1961) The reduction of Schiff bases by Grignard reagents with the addition of cobaltous chloride. Naturwissenschaften 48, p. 303.

Grignard reactions of

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

Grignard reactions of amino nitriles in relation to) Grignard reaction (of amino nitriles

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

Grignard reagent effect on) Grignard reaction (with Schiff bases)

Thies, Heinrich and Schönenberger, Helmut (1956) The reaction of Grignard compounds with Schiff bases. II. The dimerization of Schiff bases in dependence on the substituents on the nitrogen and on the nature of the Grignard reagent. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 289 (8), pp. 408-417.

Grignard reagents Role: RCT (Reactant)

Thies, Heinrich and Schönenberger, Helmut and Beutel, R. (1972) Reactions of alpha -aminonitriles. IX. Reaction of alpha -aminonitriles with alkynyl and alkyl Grignard compounds. Archiv der Pharmazie 305 (1), pp. 18-26.

growth of

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

hexestrol deriv. binding by) Estrogens Role: BIOL (Biological study) (receptor for

Hartmann, Rolf W. and Schwarz, Walter and Schönenberger, Helmut (1983) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols. Journal of medicinal chemistry 26 (8), pp. 1137-1144.

hexestrol deriv. binding by) Molecular structure-biological activity relationship (estrogen receptor-binding

Hartmann, Rolf W. and Schwarz, Walter and Schönenberger, Helmut (1983) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols. Journal of medicinal chemistry 26 (8), pp. 1137-1144.

highly active carboplatin deriv.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

hormone dependence in) Mammary gland (neoplasm

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

hormone dependence in) platinum complex mammary carcinoma inhibition hydroxyphenylethylenediaminedichloroplatinum mammary carcinoma inhibition

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

hormone-dependent

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

Hydrocinnamamide (anesthetic activity of)

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Constitution and pharmacological activity of N-aminoacylephedrines, a new class of local anesthetics. Kongr. Pharm. Wiss., Vortr. Originalmitt., 23., Muenster, (Westfalen), Ger. 1963, pp. 361-367.

Hydrolysis Kinetics of hydrolysis (of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes

Nikolov, G. St and Trendafilova, N. and Schönenberger, Helmut and Gust, Ronald and Kritzenberger, J. and Yersin, Hartmut (1994) Molecular mechanical and quantum chemical study on the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes. Part I. Reactants and products. Inorganica chimica acta 217 (1-2), pp. 159-170.

Hydrolysis (of (+-)- threo- and erythro-1

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

Hydrolysis kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes) Substituent effects (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes vs. breast cancer cytotoxicity) Substitution reaction kinetics (of platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes with iodide) Antitumor agents (platinum bis(fluorophenyl)ethylenediamine acetate deriv. complexes as) platinum bisfluorophenylethylenediamine acetate deriv prepn cytotoxicity fluorophenylethylenediamine platinum acetate deriv prepn cytotoxicity cytotoxicity platinum bisfluorophenylethylenediamine acetate deriv substituent kinetics substitution platinum bisfluorophenylethylenediamine acetate deriv breast cancer cytotoxicity platinum bisfluorophenylethylenediamine acetate diastereoisomer platinum bisfluorophenylethylenediamine acetate prepn cytotoxicity

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1996) Breast cancer inhibiting diastereomeric diacetato[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) derivatives: synthesis and studies on the relationship between reactivity and antitumor activity. Inorganica chimica acta 250 (1-2), pp. 203-218.

hydroxybenzamide deriv. effect on) Benzoic acid Benzoic acid Salicylic acid (bactericidal action of)

Schönenberger, Helmut and Holzheu-Eckardt, Juergen and Bamann, Eugen and Mehnert, Brigitte (1963) Chemical constitution and bacteriostatic activity of isomeric hydroxybenzamides. II. Antimycotic substances. Arzneimittel-Forschung = Drug research 13, pp. 936-939.

hydroxyphenyl ethylenediamines ethylenediamines hydroxyphenyl amines ethylene phenols anisoles phenols anisoles amines ethylene anisoles phenols amines ethylene imidazolidines phenyl

Schönenberger, Helmut and Bernhauer, H. (1970) Cytostatics. 13. Synthesis of meso-N,N'-dimethyl-alpha ,alpha '-bis(4-hydroxyphenyl)ethylenediamine. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 303 (10), pp. 804-812.

hydroxyphenylethylenediamine sulfatoplatinum complexes as

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

hydroxyphenylethylenediamineplatinum complexes as

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

hyperthermic limb perfusion cytostatic chemosensitivity

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Imines (reaction of ket-

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1960) Reactions of Schiff bases. VIII. The reactions of ketimines with Mg-MgI2 mixture and with aluminum amalgam. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaf 293, pp. 67-73.

in alpha -(dimethylamino)-N-(beta -hydroxy-alpha -methylphenethyl)-N-methylhydrocinnamamide) EPHEDRINE STEREOISOMERISM STEREOISOMERISM EPHEDRINE PSEUDOEPHEDRINE STEREOISOMERISM

Schönenberger, Helmut and Fuchsberger, K. D. and Brinkmann, Rolf (1967) Separation of the organic bases by Craig partition. VII. Acyl migration in the stereoisomeric N-(N,N-dimethylphenylalanyl)ephedrines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (2), pp. 126-135.

in cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes undergoing hydrolysis

Nikolov, G. St and Trendafilova, N. and Schönenberger, Helmut and Gust, Ronald and Kritzenberger, J. and Yersin, Hartmut (1994) Molecular mechanical and quantum chemical study on the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes. Part I. Reactants and products. Inorganica chimica acta 217 (1-2), pp. 159-170.

in Escherichia coli) platinum complex antitumor screening Escherichia

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthard (1984) cis-Dichloro[bis(oligopeptide ester)]platinum(II) complexes, study on the detection of antitumor activity with bacteriological test systems. Archiv der Pharmazie 317 (9), pp. 760-767.

in estrophilic platinum complex effect on uterine morphol.) Estrogens Role: BIOL (Biological study) (receptors for

Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.

in estrophilic platinum complex effect on uterine morphol.) estrophilic platinum complex uterus

Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.

in human mammary gland) Mammary gland (neoplasm

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

in human) aminoethane platinum complex prepn antitumor

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

in human) Cytoplasm (cytosol

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

in mammary gland

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

in presence of transition metal halides) Transition metal halides (Grignard reaction with Schiff bases in presence of) Grignard reaction (with Schiff bases in presence of transition metal halides)

Thies, H. and Schönenberger, Helmut and Zeller, A. (1965) Reactions of Schiff bases. XI. Effect of heavy metal halides on the reaction between Grignard-type compounds and Schiff bases. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (1), pp. 26-33.

in prostate) Prostate gland (neoplasm

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

infrared (of N

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

inhibition by bis(hydroxyphenyl)alkanes) Neoplasm inhibitors (mammary

Schönenberger, Helmut and Kranzfelder, Gerhard and Schmitt-Wallenborn, Helga (1978) Bis(3-hydroxyphenyl)alkane compounds.

inhibition by hexafluorobis(hydroxyphenyl)butanes and -butenes) fluorinated bishydroxyphenylbutane antitumor hexafluorobishydroxyphenylbutane bishydroxyphenylbutane estrogenic hexafluorobishydroxyphenylbutane bishydroxyphenylbutane phenol hexafluorobutanediyl prepn antitumor

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

inhibition of

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

inhibition of hormone-dependent

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

inhibitors

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

Müller, Richard and Bednarski, Patrick J. and Schönenberger, Helmut (1992) (1,2-Diaryl-1,2-ethylenediamine)platinum(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with different types of coordination in the solid state, in solution and reactions with nucleophiles. Inorganica chimica acta 195 (1), pp. 77-87.

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.

inhibitors [Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent

Gust, Ronald and Heinrich, Heike and Krauser, Rudolf and Schönenberger, Helmut (1999) [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities. Inorganica chimica acta 285 (2), pp. 184-189.

inhibitors prepn. and antitumor activity of platinum fluorophenylethylenediamine dicarboxylato complexes) Substitution reaction kinetics (nucleophilic of platinum fluorophenylethylenediamine dicarboxylato complexes with iodide) Carboxylic acids Role: BAC (Biological activity or effector

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

interferon and lymphotoxins effect on) Neoplasm inhibitors (carcinoma

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

interferons and lymphotoxins as

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

interferons and lymphotoxins effect on) Lymphokines and Cytokines Role: BIOL (Biological study) (tumor necrosis factor-beta

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

Isomerism and Isomers (stereo-

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis. Archiv der Pharmazie 322 (1), pp. 25-29.

Isotopic effects (in redn. of Schiff bases with Al catalyst) Catalysts and Catalysis (in redn.

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

Ketones Role: BIOL (Biological study) (amino

Schönenberger, Helmut and Bastug, T. and Bindl, L. and Adam, Adelheid and Adam, Dieter and Petter, A. and Zwez, W. (1969) Action mechanism of antimicrobial beta -amino ketones. Pharmaceutica acta Helvetiae 44 (11), pp. 691-714.

Kidney Neoplasm Organ (platinum complex uptake by) platinum complex tumor uptake antitumor platinum complex kidney uptake

Zeisler, R. and Lux, F. and Seidenberger, H. and Schönenberger, Helmut and Beck, W. (1979) Studies on the distribution of platinum in tumor-bearing rats after the administration of platinum co-ordination complexes used in cancer chemotherapy. In: Nuclear activation techniques in the life sciences 1978: proceedings of a Symposium on Nuclear Activation Techniques in the Life Sciences held by the International Atomic Energy Organsation in Vienna, 22-26 May 1978. Publication / Division of Scientific and Technical Information, International Atomic Energy Agency, 492. International Atomic Energy Agency, Vienna, pp. 467-477. ISBN 92-0-010079-1.

Kinetics of metalation (cycloplatination

Bednarski, Patrick J. and Ehrensperger, Edmund and Schönenberger, Helmut and Burgemeister, Thomas (1991) Aqueous chemistry of mixed-amine cis- and transplatin analogues. Intramolecular preference for a kinetic six-membered ring over a thermodynamic five-membered ring ortho-platination product. Inorganic chemistry 30 (15), pp. 3015-3025.

lipid soly. in relation) ephedrine diastereoisomer anesthetic lipid soly ephedrine anesthetic

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.

Lipids Role: BIOL (Biological study) (anesthetic diastereomers of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine soly. in) Molecular structure-biological activity relationship (anesthetic

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.

liver function in relation to)

Wrba, Heinrich and Schönenberger, Helmut and Bamann, Eugen and Lang, Rudolf (1962) Evaluation of the changes in the content of free nucleotides in different functional states of the liver. Naturwissenschaften 49, pp. 399-400.

Local *Chemistry

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

local chemistry

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

Local)

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

mammary

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

mammary carcinoma inhibition by) Carcinoma (of mammary gland

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

mammary estrogen receptor binding in relation to) Estrogens Role: BIOL (Biological study) (receptors for

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

Mammary gland (cancer of

Schönenberger, Helmut and Kranzfelder, G. and Hoffmann, E. and Egginger, G. and Schmitt, H. and Taneja, A. K. (1976) Experimental chemotherapy of the breast cancer. Die Pharmazie 31 (9), pp. 590-597.

Mammary gland (carcinoma

Schönenberger, Helmut and Kranzfelder, Gerhard and Schmitt-Wallenborn, Helga (1978) Bis(3-hydroxyphenyl)alkane compounds.

Mammary gland (neoplasm

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Mammary gland (neoplasm of

Schönenberger, Helmut and Griebl, G. and Adam, D. and Adam, A. (1971) Effect of meso- and dl-N,N'-dibutyl-alpha,alpha-bis(3-chloro-4-methoxyphenyl)ethylenediamine on the mammary tumor in the Sprague-Dawley rat induced by 7,12-dimethylbenz[alpha]anthracene (DMBA). 14. Cytostatic compounds. Arzneimittel-Forschung = Drug research 21 (12), pp. 2104-2106.

mammary gland carcinoma of humans response to

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

mammary gland carcinoma response to interferon and) Interferons Role: BIOL (Biological study) (gamma

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

mammary gland carcinoma response to lymphotoxin and) breast cancer inhibition interferon lymphotoxin mammary carcinoma inhibition interferon lymphotoxin

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

Mannich bases Role: BAC (Biological activity or effector

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

mechanism of

Hartmann, R. W. and Schönenberger, Helmut and Wrobel, K. H. (1982) 3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat. Journal of cancer research and clinical oncology 103 (3), pp. 241-254.

mechanism of action of) review local anesthetic nerve anesthetic review

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 1. Theories of action, questions, and means of solution. Pharmazie 27 (4), pp. 246-250.

mechanism of) Fungicides and Fungistats (beta -aminoketones as) review aminoketone antimycotic mechanism fungus aminoketone review

Schönenberger, Helmut and Kroetsch, Ulrich and Seidenberger, H. (1975) Mechanism of action of antimycotic beta -aminoketones. Deutsche Apotheker-Zeitung 115 (34), pp. 1244-1248.

mechanism of) Kinetics (of inhibition

Laske, Reiner and Meindl, Wolfgang and Holler, Eggehard and Schönenberger, Helmut (1989) Investigations on the mode of action of antimycobacterial benzylamines. Archiv der Pharmazie 322 (5), pp. 297-299.

mechanism of) REDN DIMERS BENZYLIDENE AMINES BENZYLIDENE AMINES REDN DIMERS AMINES BENZYLIDENE REDN DIMERS

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. V. Mechanism of the formation of diphenylethylenediamines from benzylidenealkylamines and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 258-268.

mechanism of) Schiff bases (redn. of

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

mechanism of) Schiff bases Role: PRP (Properties) (redn. by activated aluminum

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. V. Mechanism of the formation of diphenylethylenediamines from benzylidenealkylamines and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 258-268.

membrane binding in relation to) anesthetic interaction membrane protein ephedrine isomer anesthesia membrane

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

menopause in relation to) Carcinoma (of mammary gland

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

mesohexestrol derivs. by) metahexestrol deriv prepn estrogen antiestrogen hexanediol diphenyl deriv

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

metabolism Mammary Neoplasms

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

metabolism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organometallic Compounds) 0 (Receptors

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

metahexestrol derivs.) Molecular structure-biological activity relationship (antiestrogenic

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

MFM (Metabolic formation)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Mn salt effect on)

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1959) The effect of manganous salts on the reaction of Schiff bases with Grignard reagents. Naturwissenschaften 46, p. 378.

Mn salt effect on) Grignard reaction (with Schiff bases

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1959) The effect of manganous salts on the reaction of Schiff bases with Grignard reagents. Naturwissenschaften 46, p. 378.

mol. mech. and quantum chem. study of) cisplatin hydrolysis mol mechanic quantum chem ammine chloro platinum hydrolysis kinetics ethylenediamine chloro platinum hydrolysis kinetics

Nikolov, G. St and Trendafilova, N. and Schönenberger, Helmut and Gust, Ronald and Kritzenberger, J. and Yersin, Hartmut (1994) Molecular mechanical and quantum chemical study on the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes. Part I. Reactants and products. Inorganica chimica acta 217 (1-2), pp. 159-170.

mol. mech. and quantum chem. study of) Molecular mechanics Quantum chemistry (of hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes) Energy level (electronic

Nikolov, G. St and Trendafilova, N. and Schönenberger, Helmut and Gust, Ronald and Kritzenberger, J. and Yersin, Hartmut (1994) Molecular mechanical and quantum chemical study on the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes. Part I. Reactants and products. Inorganica chimica acta 217 (1-2), pp. 159-170.

mol. structure)

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Molecular structure ([rac-1

Gust, Ronald and Schnurr, Beate and Krauser, Rudolf and Bernhardt, Günther and Koch, Marion and Schmid, Beate and Hummel, Evelyn and Schönenberger, Helmut (1998) Stability and cellular studies of [rac-1,2-bis(4-fluorophenyl)ethylenediamine][cyclobutane-1,1-dicarboxylato]platinum(II), a novel, highly active carboplatin derivative. Journal of Cancer Research and Clinical Oncology 124 (11), pp. 585-597.

Molecular structure-biological activity relationship (anesthetic

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

Molecular structure-biological activity relationship (local anesthetic

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics. Pharmazie 27 (8), pp. 522-523.

Molecular structure-biological activity relationship (neoplasm-inhibiting

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Molecular structure-biological activity relationships (fungicidal

Schönenberger, Helmut and Lippert, P. (1970) Cytostatics 11. Comparative study on the antimicrobial action of tertiary and quaternary beta-aminoketones. Pharmazie 25 (10), pp. 617-620.

Muscle relaxants (alkyl[(diphenylacetamido)methyl]dimethylammonium iodides) phenylacetamidomethylammonium iodide spasmolytic acetamidomethylammonium ammonium diphenylacetamidomethyl iodide acetamidomethylammonium iodide

Petter, A. and Schönenberger, Helmut and Gutschow, K. and Kuehling, V. and Taneja, V. (1972) Synthesis of spasmolytic N-[(diphenylacetamido)methyl]dimethylalkyammonium iodides. Archiv der Pharmazie 305 (11), pp. 820-828.

Mycobacterium (control of

Schönenberger, Helmut and Von Angerer, Erwin and Meindl, Wolfgang Rudolf and Ruckdeschel, Gotthard (1985) Synergistic bactericides.

Mycobacterium leprae (inhibition of

Dhople, A. M. and Strong, L. C. and Meindl, W. and Schönenberger, Helmut and Gardner, G. D. (1991) In vitro and in vivo effects of N-methyl-3,5-dichlorobenzylamine hydrochloride on Mycobacterium leprae. Arzneimittel-Forschung = Drug research 41 (3), pp. 253-256.

Mycobacterium tuberculosis (antibiotic susceptibility of

Meindl, Wolfgang and Schönenberger, Helmut (1989) Influences of the culture medium in the testing of antimycobacterial compounds. Archiv der Pharmazie 322 (7), pp. 453-455.

N'-dibutyl-1

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

Schönenberger, Helmut and Brinkmann, R. and Baman, E. (1963) Separation of organic bases by Craig distribution. II. Constellation of diastereomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 762-770.

N'-dibutyl-alpha

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

N-aminoacyl ephedrine derivs. as) Heart (circulation in

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1967) Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type. Pharmaceutica acta Helvetiae 42 (8-10), pp. 593-603.

N-aminoacyl ephedrine derivs. effect on) Anesthesia (from N-aminoacyl ephedrine derivs.) LOCAL ANESTHETICS MOL CONFIGURATION LOCAL ANESTHETICS EPHEDRINES NERVE EFFECT NERVE EFFECT EPHEDRINES RECEPTOR EPHEDRINES BINDING

Schönenberger, Helmut and Petter, Alfred and Zwez, W. (1967) Correlations between active substance and receptor in local anesthetics of the N-aminoacyl ephedrine type. Pharmaceutica acta Helvetiae 42 (8-10), pp. 593-603.

N-aminoacylephedrine derivs. as

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

Neoplasm (platinum detn. in

Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.

neoplasm inhibiting activity in relation to) acetoxyphenylindene ethylmethylacetoxy prepn tumor inhibitor indene acetoxyphenyl anticancer

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

neoplasm inhibition in relation to) Deoxyribonucleic acids Role: PRP (Properties) (interaction of

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

neoplasm inhibition in relation to) Neoplasm inhibitors (platinum compds.

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

neoplasm inhibition in relation to) Neoplasm inhibitors (platinum-peptide ester complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

neoplasm inhibition in relation to) Protein formation (antitumor platinum compds. effect on

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

neoplasm inhibition mechanism in relation to) cis platinum antitumor mechanism

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

neoplasm inhibition mechanism in relation to) Estrogens Role: BIOL (Biological study) (receptors for

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

neoplasm inhibition mechanism in relation to) Neoplasm inhibitors (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum as) Deoxyribonucleic acid formation (cis-dichlorobis(glycylglycine Et ester)platinum and cis-dichlorodiammineplatinum inhibition of

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

Neoplasm inhibitors ((acetoxyphenyl)hexadiene

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, Hans P. (1982) Syntheses and evaluation of the potentially estrophilic cytostatics. 2,3-Epoxy-3,4-bis(4'-acetoxyphenyl)-4-hexene and 2,3,4,5-bisepoxy-3,4-bis(4'-acetoxyphenyl)hexane. Archiv der Pharmazie 315 (6), pp. 515-519.

Neoplasm inhibitors ((diphenylethylenediamine) platinum II complexes) diphenylethylenediamine platinum complex formulation antitumor diphenylethylenediamine platinum complex

Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Von Angerer, Erwin and Engel, Juergen (1984) (1,2-Diphenylethylenediamine)-platinum(II) complex compounds.

Neoplasm inhibitors ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides) Uterus ((hydroxyphenyl)(trifluoropropyl)hydroxybenzamides effect on) Estrogens Role: RCT (Reactant)

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Schönenberger, Helmut (1990) Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity. Archiv der Pharmazie 323 (2), pp. 73-78.

Neoplasm inhibitors ([(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties. Archiv der Pharmazie 322 (2), pp. 67-73.

Neoplasm inhibitors ([bis(hydroxyphenyl)ethylenediamine]dichloroplatinum complexes

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

Neoplasm inhibitors (acetoxy(acetoxyphenyl)ethylmethylindene) Receptors Role: RCT (Reactant)

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

Neoplasm inhibitors (antiestrogens) Estrogens Role: BSU (Biological study

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Neoplasm inhibitors (antiestrogens) Menopause (antiestrogens and estrogens effect on mammary carcinoma in humans in relation to) Estrogens Role: BIOL (Biological study) (inhibitors and

Michel, R. T. and Schönenberger, Helmut (1981) Effects of new anti-estrogens on serially transplanted human breast carcinomas in nude mice. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 199-204. ISBN 3-437-10683-X; 0-89574-154-7 .

Neoplasm inhibitors (bis(acetoxyphenyl)phenylbutenes) Estrogens Role: USES (Uses) (inhibitors

Schneider, Martin R. and Ball, Hartwig and Schönenberger, Helmut (1985) Acetoxy-substituted 1,1,2-triphenylbut-1-enes with antiestrogenic and mammary tumor inhibiting properties. Journal of medicinal chemistry 28 (12), pp. 1880-1885.

Neoplasm inhibitors (bis(chloroethyl)aminomethylurethanes) chloroethylaminomethylurethane neoplasm inhibitor urethane chloroethylaminomethyl neoplasm inhibitor sarcoma inhibitor chloroethylaminomethylurethane cytostatic chloroethylaminomethylurethane

Schönenberger, Helmut and Schmidt, F. and Bindl, L. (1975) Cytostatics. 22. Tumor inhibitory N-[bis(2-chloroethyl)aminomethyl]urethanes. Zeitschrift für Krebsforschung und klinische Onkologie 84 (3), pp. 227-240.

Neoplasm inhibitors (bis(hydroxyphenyl)hexane as

Hartmann, R. W. and Schönenberger, Helmut and Wrobel, K. H. (1982) 3,4-Bis(3'-hydroxyphenyl)hexane - a new mammary tumor-inhibiting compound. Studies on the mechanism of action on the DMBA-induced, hormone-dependent mammary tumor of the rat. Journal of cancer research and clinical oncology 103 (3), pp. 241-254.

Neoplasm inhibitors (carcinoma

Spruss, Thilo and Gust, Ronald and Müller, Richard and Engel, Juergen and Schönenberger, Helmut (1990) Mammary-tumor-inhibiting properties of (S,S)-[1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II). Archiv der Pharmazie 323 (2), pp. 99-102.

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

Neoplasm inhibitors (cis-dichlorobis(alpha -amino acid ester) platinum complexes) amino acid platinum antitumor

Wappes, Beate and Schönenberger, Helmut and Bissinger, Herbert and Beck, Wolfgang (1983) Antitumor activity of cis-dichlorobis(alpha -amino acid ester)platinum complexes. Archiv der Pharmazie 316 (10), pp. 854-862.

Neoplasm inhibitors (DES catechol analogs) Uterus (DES catechol analogs effect on growth of) Receptors Role: BIOL (Biological study) (estradiol binding by

Schneider, M. R. and Schönenberger, Helmut and Michel, R. T. and Fortmeyer, H. P. (1982) Synthesis and evaluation of catechol analogs of diethylstilbestrol on a hormone-dependent human mammary carcinoma implanted in nude mice. Journal of cancer research and clinical oncology 104 (3), pp. 219-227.

Neoplasm inhibitors (dialkylbis(hydroxyphenyl)ethanes as) Receptors Role: BIOL (Biological study) (estradiol binding by

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

Neoplasm inhibitors (dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers

Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl. A), pp. 125-130.

Neoplasm inhibitors (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Neoplasm inhibitors (estrophilic platinum complex as

Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.

Neoplasm inhibitors (ethylenediamine platinum complexes) ethylenediamine platinum complex antitumor prepn

Brunner, Henri and Kroiss, Reinhard and Schmidt, Manfred and Schönenberger, Helmut (1986) Synthesis of new ethylenediamine-platinum(II) complexes starting from amino acids and their antitumor activity. European journal of medicinal chemistry 21 (4), pp. 333-338.

Neoplasm inhibitors (excitatory amino acid antagonists as) Amino acids Role: BIOL (Biological study) (excitatory

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1991) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part III. Combination experiments. Archiv der Pharmazie 324 (3), pp. 153-160.

Neoplasm inhibitors (glycylglycine Et ester platinum complex) Deoxyribonucleic acid formation Ribonucleic acid formation (glycylglycine Et ester platinum complex inhibition of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

Neoplasm inhibitors (hexafluorobis(hydroxyphenyl)butanes and -butenes

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

Neoplasm inhibitors (lymphocytic leukemia

Brunner, Henri and Dafinger, Willi and Schönenberger, Helmut (1989) Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma. Inorganica chimica acta 156 (2), pp. 291-301.

Neoplasm inhibitors (mammary gland

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

Otto, Angela M. and Bednarski, Patrick J. and Eggers, Hella and Truembach, Barbara and Schönenberger, Helmut (1992) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)enthylenediamine] dichloroplatinum(II), an estrogenic platinum(II)-complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and pharmacological letters 1 (3), pp. 103-106.

Neoplasm inhibitors (mammary gland carcinoma

Müller, Richard and Bednarski, Patrick J. and Schönenberger, Helmut (1992) (1,2-Diaryl-1,2-ethylenediamine)platinum(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with different types of coordination in the solid state, in solution and reactions with nucleophiles. Inorganica chimica acta 195 (1), pp. 77-87.

Neoplasm inhibitors (melanoma

Meyer, Thomas and Goehl, Jonas and Hohenberger, Werner and Christl, Claudia and Bernhardt, Günther and Spruss, Thilo and Schönenberger, Helmut (1993) The choice of cytostatic in hyperthermic isolated limb perfusion. Chemosensitivity testing on five human melanoma cell lines. Chirurgisches Forum fuer Experimentelle und Klinische Forschung, pp. 89-94.

Neoplasm inhibitors (platinate chloro substituted-ethylendiamine complexes) Amino acids Role: RCT (Reactant)

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

Neoplasm inhibitors (platinated DNA after treatment of cancer cells with new platinum complexes)

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Neoplasm inhibitors (platinum ammine chloro complexes with aminoethoxyestrone or -estradiol as)

Altman, Janina and Castrillo, Thais and Beck, Wolfgang and Bernhardt, Günther and Schönenberger, Helmut (1991) Metal complexes with biologically important ligands. 62. Platinum(II) complexes of 3-(2-aminoethoxy)estrone and -estradiol. Inorganic Chemistry 30 (21), pp. 4085-4088.

Neoplasm inhibitors (platinum benzylethylenediamine complexes as) platinum benzylethylenediamine prepn antitumor agent

Brunner, Henri and Schönenberger, Helmut and Schmidt, Manfred and Holzinger, Ulrich and Unger, Gerfried and Engel, Juergen (1986) (1-Benzylethylenediamine) platinum(II) complexes as antitumor agents.

Neoplasm inhibitors (platinum bis(difluorohydroxyphenyl)ethylenediamine complexes

Gust, Ronald and Schönenberger, Helmut (1993) Breast cancer-inhibiting properties of leaving group derivatives of [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II). European Journal of Medicinal Chemistry 28 (2), pp. 117-127.

Neoplasm inhibitors (platinum bis(hydroxypheny)ethylenediamine complexes

Gust, Ronald and Schönenberger, Helmut (1993) Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. European journal of medicinal chemistry 28 (2), pp. 103-115.

Neoplasm inhibitors (platinum chloro complexes with pyridylalkyleneamines and pyridylalkylamines and quinolylalkylamines as) platinum diamine prepn antitumor activity pyridylalkyleneamine platinum chloro pyridylalkylamine platinum chloro quinolylalkylamine platinum chloro

Brunner, Henri and Schmidt, Manfred and Schönenberger, Helmut (1986) Synthesis and in vitro antitumor activity of dichloroplatinum complexes of pyridine- and quinoline-amine and -imine ligands and of carbocyclic ethylenediamine ligands. Inorganica chimica acta 123 (4), pp. 201-207.

Neoplasm inhibitors (platinum complex of phenylindoles) tumor inhibitor indole platinum complex prepn

Von Angerer, Erwin and Knebel, Norbert and Schönenberger, Helmut and Engel, Juergen (1988) Diamineplatinum(II) complex compounds with a hydroxylated 2-phenylindole ring, procedure for their preparation, pharmaceutical compositions containing them, and their use as antitumor agents.

Neoplasm inhibitors (platinum complexes with bis(fluorophenyl)ethylenediamines)

Mueller, Richard and Gust, Ronald and Jennerwein, Margaretha and Reile, Herta and Laske, Reiner and Krischke, Walter and Bernhardt, Günther and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), pp. 341-348.

Neoplasm inhibitors (platinum complexes with bis(hydroxyphenyl)ethylenediamines or bis(methoxyphenyl)ethylenediamines) antitumor activity platinum methoxyphenylethylenediamine ethylenediamine methoxyphenyl platinum complex

Karl, Johann and Schönenberger, Helmut (1988) Antitumor activity of o-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes and their methyl ethers. Archiv der Pharmazie 321 (7), pp. 405-410.

Neoplasm inhibitors (platinum diphenylethylenediamine complexes) platinum phenylethylenediamine prepn antitumor agent

Schönenberger, Helmut and Von Angerer, Erwin and Karl, Johann and Jennerwein, Margaretha and Engel, Juergen (1986) 1,2-Diphenylethylenediamine platinum complexes as antitumor agents.

Neoplasm inhibitors (platinum phenylindolealkyleneamino complexes) platinum phenylindolealkyleneamine complex prepn antitumor

Von Angerer, Erwin and Knebel, Norbert and Schönenberger, Helmut and Engel, Juergen (1988) Preparation of aminoplatinum phenylindole antitumor agents.

Neoplasm inhibitors (stilbestrol analogs as) stilbestrol deriv antitumor aminostilbestrol cancer inhibition carcinoma mammary aminostilbene

Schönenberger, Helmut and Bastug, T. (1972) Cytostatics. 15. Antimicrobial and antitumor properties of nitrogen-containing stilbestrol analogs. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 305 (4), pp. 285-290.

Neoplasm inhibitors (tetramethylbis(fluorohydroxyphenyl)ethane derivs.

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

Neoplasm inhibitors (triphenylbutenes) phenylbutene prepn neoplasm inhibitor butene triphenyl neoplasm inhibitor

Schönenberger, Helmut and Schneider, Martin and Schuderer, Michael and Engel, Juergen (1987) Preparation of 1,1,2-triphenyl-1-butenes as tumor inhibitors.

Neoplasm inhibitors Role: BAC (Biological activity or effector

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

neoplasm-inhibiting activity in relation to) Neoplasm inhibitors (platinum complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting

Schönenberger, Helmut and Wappes, B. and Jennerwein, M. and Berger, M. (1984) Development of selective, active platinum complexes. Contributions to oncology = Beiträge zur Onkologie 18 (Resistenzprobl. Chemo-Radiother. Malig. Tumoren), pp. 48-57.

Neoplasms (inhibitors of

Schönenberger, Helmut and Adam, A. and Adam, D. (1966) The action of aminomethylating carcinostatics on experimental tumors. IV. Cytostatic agents. Arzneimittel-Forschung = Drug research 16 (6), pp. 734-738.

Nerve (Ranvier node

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mechanism of action of local anesthetics. 5. Influence of stereoisomers of N-(N-dimethylphenylalanyl) ephedrine on the steady state current-voltage behavior of Ranviers' node. Pharmazie 27 (12), pp. 759-760.

nerve receptor and) EPHEDRINES PHENYLALANINE PHENYLALANINE EPHEDRINES ANESTHETICS EPHEDRINES

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

Nerves (anesthetic effect on) Fungicides or Fungistats (hydroxyaryl amides as)

Schönenberger, Helmut and Holzheu-Eckardt, Juergen and Bamann, Eugen and Mehnert, Brigitte (1962) Correlations between chemical structure and antimycotic activity in isomeric hydroxybenzamides. Arzneimittel-Forschung = Drug research 12, pp. 1162-1166.

Nitriles Role: RCT (Reactant)

Thies, Heinrich and Schönenberger, Helmut and El-Zanaty, M. (1972) Reactions of alpha -amino nitriles. 10. Synthesis of 1-amino-1-aryl-2-alkynes with cholinergic and cholinolytic properties. Arzneimittel-Forschung = Drug research 22 (7), pp. 1138-1144.

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. V. Adduct formation and dimerization of alpha -piperidinoacetonitrile in reaction with butylmagnesium chloride. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (3), pp. 168-174.

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. VII. Dimer exchange products of aromatic substituted aminonitriles. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (11), pp. 803-807.

nonpreparative)

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

nonpreparative) (formation of

Beck, Wolfgang and Purucker, Bernhard and Girnth, Michael and Schönenberger, Helmut and Seidenberger, Horst and Ruckdeschel, Gotthard (1976) Synthesis, in vivo and in vitro studies on the antineoplastic effect of cis-dichloro-dipeptide ester-platinum(II) complexes. Zeitschrift für Naturforschung B: Anorganische Chemie, organische Chemie 31B (6), pp. 832-845.

normal uterine morphol. response to) Uterus (estrophilic platinum complex effect on morphol. of

Amselgruber, W. and Sinowatz, F. and Spruss, Thilo and Schneider, M. R. and Karl, J. and Schönenberger, Helmut (1987) Effect of estrophilic platinum complex on the mouse uterus. Virchows Archiv: B 53 (4), pp. 198-207.

Nucleic acids (in liver function test) Liver (nucleic acid metabolism by

Wrba, Heinrich and Schönenberger, Helmut and Bamann, Eugen and Lang, Rudolf (1962) Evaluation of the changes in the content of free nucleotides in different functional states of the liver. Naturwissenschaften 49, pp. 399-400.

of (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers) Anesthesia (from (dimethylphenylalanyl)ephedrine and (dimethylphenylalanyl)pseudoephedrine diastereomers

Petter, A. and Schönenberger, Helmut and Zwez, W. (1972) Mode of action of local anesthetics. 4. Correlation between lipid solubility and biological activity of diastereomeric N-[N-dimethylphenylalanyl]ephedrine. Detection of asymmetric membrane structures as the site of action of local anesthetics. Pharmazie 27 (8), pp. 524-525.

of [(hydroxyphenyl)ethylenediamine]dichloroplatinum(II) stereoisomer complexes) platinum complex stereoisomer antitumor structure

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes. Part II. Biological properties. Archiv der Pharmazie 322 (2), pp. 67-73.

of [(hydroxyphenyl)ethylenediamine]platinum(II) complexes) Neoplasm inhibitors (mammary gland

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

of alkylbenzylamines) alkylbenzylamine tuberculostatic Mycobacterium alkylbenzylamine benzylamine alkyl tuberculostatic

Ruckdeschel, G. and Stransky, D. and Schönenberger, Helmut (1976) Studies of the correlation between structure and tuberculostatic effect of the benzylamine class. Pharmazie 31 (6), pp. 374-381.

of amino acid antagonists targeting for aminoacyl-tRNA synthetases) aminoacyl tRNA synthetase inhibitor antibacterial

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

of amino ketones) Bactericidal action (of amino ketones) fungistatic compd bacteriostatic compd antimicrobial compd germicidal compd amino ketone germicide propiophenones germicide

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

of aminoacryldimethylaniline derivs.) Anesthetics (membrane binding of

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

of aminoacylphenylalkylamines) phenylalanylphenylalkylamine antidepressant

Schönenberger, Helmut and Petter, A. and Beck, D. and Endres, W. and Servatius, H. J. (1976) Studies on the mechanisms of action of local anesthetics. Part 9. N-Aminoacyl-beta -phenylalkylamine studies for the development of antidepressants from psychostimulants. Pharmazie 31 (12), pp. 882-886.

of aminoketones) amino ketone fungicides fungicides amino ketone ketone amino fungicides propiophenones fungicides

Schönenberger, Helmut and Bastug, T. and Bindl, L. and Adam, Adelheid and Adam, Dieter and Petter, A. and Zwez, W. (1969) Action mechanism of antimicrobial beta -amino ketones. Pharmaceutica acta Helvetiae 44 (11), pp. 691-714.

of aminoketones) Bactericidal action (of aminoketones) aminoketones stability antimicrobial activity antimicrobial activity aminoketones stability ketone antimicrobial activity aminopropiophenones antimicrobial activity

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

of ammine phenylalkylamine complexes) Chromatography (high-performance

Bednarski, Patrick J. and Ehrensperger, Edmund and Schönenberger, Helmut and Burgemeister, Thomas (1991) Aqueous chemistry of mixed-amine cis- and transplatin analogues. Intramolecular preference for a kinetic six-membered ring over a thermodynamic five-membered ring ortho-platination product. Inorganic chemistry 30 (15), pp. 3015-3025.

of ammine phenylalkylamine complexes) Hydrolysis Kinetics of hydrolysis (of platinum ammine phenylalkylamine complexes) Metalation (cycloplatination

Bednarski, Patrick J. and Ehrensperger, Edmund and Schönenberger, Helmut and Burgemeister, Thomas (1991) Aqueous chemistry of mixed-amine cis- and transplatin analogues. Intramolecular preference for a kinetic six-membered ring over a thermodynamic five-membered ring ortho-platination product. Inorganic chemistry 30 (15), pp. 3015-3025.

of bis(3-hydroxyphenyl)ethylenediamine and their platinum complexes) hydroxyphenylethylenediamine stereoisomer platinum hydroxyphenylethylenediamine stereoisomer amine hydroxyphenylethylenedi platinum stereoisomer

Jennerwein, Margaretha and Gust, Ronald and Müller, Richard and Schönenberger, Helmut and Engel, Juergen and Berger, Martin R. and Schmaehl, Dietrich and Seeber, Siegfried and Osieka, Reinhardt (1989) Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Part I. Synthesis. Archiv der Pharmazie 322 (1), pp. 25-29.

of butestrols and metabutestrols) Mammary gland (neoplasm

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

of butestrols and metabutestrols) Molecular structure-biological activity relationship (estrogen receptor-binding

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

of cinchocaine homologs) Anesthetics (local

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Action mechanism of local anesthetics. 3. Correlation between lipid solubility and biological action of homologous local anesthetics. Pharmazie 27 (8), pp. 522-523.

of D-homosteroids and 1

Brinkmann, Rolf and Schönenberger, Helmut and Petter, Alfred and Fuchsberger, K. D. and Zwez, W. (1967) Chemistry and local anesthetic effect of stereoisomeric N-aminoacyl ephedrines. Pharmaceutica acta Helvetiae 42 (8-10), pp. 576-592.

of dialkylbis(hydroxyphenyl)ethanes) alkylbishydroxyphenylethane prepn antiestrogen phenylethane dialkylbishydroxy antiestrogen antitumor estrogen inhibitor dialkylbishydroxyphenylethane neoplasm inhibitor dialkylbishydroxyphenylethane

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

of dialkylbis(hydroxyphenyl)ethanes) Mammary gland (neoplasm

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

of dichlorobis(cycloalkylamine)platinum(II) complexes)

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

of dichlorobis(hydroxyphenyl)ethylenediamineplatinum isomers) ethylenediamineplatinum antitumor structure activity platinum complex antitumor structure activity

Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl. A), pp. 125-130.

of dimethylphenylalanylephedrine

Schönenberger, Helmut and Petter, A. and Zwez, W. (1972) Mechanism of action of local anesthetics. 6. Binding of local anesthetics to complementary membrane structures. Pharmazie 27 (12), pp. 760-767.

of hexestrol derivs.) hydroxyphenylethane prepn estrogen receptor binding hexestrol deriv estrogen receptor binding structure activity hexestrol deriv

Hartmann, Rolf W. and Schwarz, Walter and Schönenberger, Helmut (1983) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols. Journal of medicinal chemistry 26 (8), pp. 1137-1144.

of human mammary carcinoma

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

of hydroxyphenylethylenediamine sulfatoplatinum complexes) Neoplasm inhibitors (mammary gland

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

of hydroxyphenylethylenediamineplatinum complexes) hydroxyphenyl ethylenediamine platinum mammary tumor inhibitor

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

of mammary gland) Mammary gland (neoplasm

Buck, C. and Wawer, A. and Mach, W. and Digel, W. and Otto, A. M. and Schönenberger, Helmut and Porzsolt, F. (1990) Synergism of lymphotoxin and interferon-gamma in the growth inhibition of breast cancer cell line MCF-7. In: Freund, M., (ed.) Cytokines in hemopoiesis, oncology, and AIDS. Springer, Berlin, pp. 205-210. ISBN 3-540-52281-6; 0-387-52281-6.

of mammary gland) Receptors Role: BIOL (Biological study) (for estrogen

Hartmann, Rolf W. and Heindl, Alexander and Schwarz, Walter and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 3. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of 2,2'-disubstituted butestrols and 6,6'-disubstituted metabutestrols. Journal of medicinal chemistry 27 (7), pp. 819-824.

of mammary tumors

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

of metahexestrol derivs.) Coupling reaction (reductive

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

of metahexestrol derivs.) Molecular structure-biological activity relationship (estrogenic

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

of N-alkylbenzylamines) benzylamine deriv Mycobacterium inhibition tuberculostat benzylamine deriv

Ruckdeschel, G. and Stransky, D. and Schönenberger, Helmut (1977) Antimycobacterial properties of N-alkylbenzylamines. Pharmazie 32 (2), pp. 119-122.

of N-aminoacyl ephedrine stereoisomers) ANESTHETIC EFFECT AMINOACYL EPHEDRINES AMINOACYL EPHEDRINES ANESTHETIC EFFECT EPHEDRINES STEREOISOMERS ANESTHESIA

Brinkmann, Rolf and Schönenberger, Helmut and Petter, Alfred and Fuchsberger, K. D. and Zwez, W. (1967) Chemistry and local anesthetic effect of stereoisomeric N-aminoacyl ephedrines. Pharmaceutica acta Helvetiae 42 (8-10), pp. 576-592.

of phenylalanyl-tRNA synthetases of Mycobacterium tuberculosis and Escherichia coli) bactericide benzylamine aminoacyl tRNA synthetase inhibition bacteria aminoacyl tRNA synthetase inhibition benzylamine benzylamine antimycobacterial activity mechanism mycobacteria sensitivity benzylamine mechanism

Laske, Reiner and Meindl, Wolfgang and Holler, Eggehard and Schönenberger, Helmut (1989) Investigations on the mode of action of antimycobacterial benzylamines. Archiv der Pharmazie 322 (5), pp. 297-299.

of phenylalanylphenylalkylamines) phenylalanylphenylalkylamine deriv antidepressant structure

Beck, D. and Fink, K. and Hoelzl, J. and Krieglstein, J. and Petter, A. and Rieger, H. and Schönenberger, Helmut (1983) Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class. Arzneimittel-Forschung = Drug research 33 (3), pp. 404-410.

of phenylpropanols and propiophenones

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

of platinum amine phenylalkylamine complexes) orthoplatination ammine methoxyphenylalkylamine isomer complex platinum isomer complex methoxyphenylalkylamine kinetics hydrolysis platinum isomer complex

Bednarski, Patrick J. and Ehrensperger, Edmund and Schönenberger, Helmut and Burgemeister, Thomas (1991) Aqueous chemistry of mixed-amine cis- and transplatin analogues. Intramolecular preference for a kinetic six-membered ring over a thermodynamic five-membered ring ortho-platination product. Inorganic chemistry 30 (15), pp. 3015-3025.

of platinum bis(difluorohydroxyphenyl)ethylenediamine complexes) antitumor agent platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex

Gust, Ronald and Schönenberger, Helmut (1993) Breast cancer-inhibiting properties of leaving group derivatives of [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II). European Journal of Medicinal Chemistry 28 (2), pp. 117-127.

of platinum complexes) platinum complex antitumor structure estrogen receptor platinum complex antitumor

Schönenberger, Helmut and Wappes, B. and Jennerwein, M. and Berger, M. (1984) Development of selective, active platinum complexes. Contributions to oncology = Beiträge zur Onkologie 18 (Resistenzprobl. Chemo-Radiother. Malig. Tumoren), pp. 48-57.

of platinum hydroxyphenylethylenediamine complexes) Neoplasm inhibitors (leukemia

Gust, Ronald and Schönenberger, Helmut and Kritzenberger, Juergen and Range, Klaus Juergen and Klement, Ulrich and Burgemeister, Thomas (1993) Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Inorganic chemistry 32 (26), pp. 5939-5950.

of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Isomerism and Isomers (diastereo-

Gust, Ronald and Schönenberger, Helmut and Kritzenberger, Juergen and Range, Klaus Juergen and Klement, Ulrich and Burgemeister, Thomas (1993) Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Inorganic chemistry 32 (26), pp. 5939-5950.

of platinum of antitumor drugs in organs and tumor tissues) platinum drug detn tissue neutron activation neutron activation analysis platinum drug tissue phosphorus tissue neutron activation analysis molybdenum tissue neutron activation analysis gold tissue neutron activation analysis trace element tissue neutron activation analysis

Trebert-Haeberlin, S. and Lux, F. and Karl, J. and Spruss, Thilo and Schönenberger, Helmut (1987) Determination of platinum and biologically important trace elements in structure-activity relationship studies on platinum-containing anti-cancer drugs. Special procedures for removing phosphorus-32 as well as for the estimation of molybdenum-99 and gold-199. Journal of radioanalytical and nuclear chemistry 113 (2), pp. 461-467.

of platinum-peptide ester complexes) antitumor platinum peptide complex structure antitumor activity platinum complex

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

of quaternary aminoketones) Bactericidal action (of quaternary aminoketones) antimicrobials aminoketones aminoketones antimicrobials quaternary aminoketones fungicides fungicides quaternary aminoketones aminopropiophenones quaternization fungicides propiophenones antimicrobials

Schönenberger, Helmut and Lippert, P. (1970) Cytostatics 11. Comparative study on the antimicrobial action of tertiary and quaternary beta-aminoketones. Pharmazie 25 (10), pp. 617-620.

of Schiff bases

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

of stilbene derivs.) Mammary gland (neoplasm

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

of stilbene derivs.) mammary neoplasm inhibitor stilbene structure activity stilbene

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

of tetramethylbis(hydroxyphenyl)ethanes) Mammary gland (neoplasm

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

of tetramethylbis(hydroxyphenyl)ethanes) methylbishydroxyphenylethane prepn antiestrogen antitumor butestrol deriv prepn antiestrogen antitumor metabutestrol deriv prepn antiestrogen antitumor antiestrogen butestrol metabutestrol deriv mammary antitumor butestrol metabutestrol deriv structure activity methylbishydroxyphenylethane

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

of uterus

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Mammary gland Prostate gland (neoplasm

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) Neoplasm inhibitors (prostate gland

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

orally active mesodichlorohydroxyphenylethylenediaminedichloroplatinum(II) platinum complex antitumor breast prostate cancer

Spruss, Thilo and Schertl, Sabine and Schneider, Martin R. and Gust, Ronald and Bauer, Kurt and Schönenberger, Helmut (1993) [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] -dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer. Journal of cancer research and clinical oncology 119 (12), pp. 707-716.

Partition (of alkylbenzylamine mixts.

Schönenberger, Helmut and Eder, Maxcimilian (1970) Separation of organic bases by Craig distribution. VIII. Separation of N-alkylbenzylamine mixtures by multiplicative distribution. Fresenius' Zeitschrift für analytische Chemie 249 (2), pp. 117-120.

Partition (of aminoacyl ephedrines between aq. solns. and org. solvents)

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig partition. V. Synthesis and separation of aminoacylephedrine isomers, a new class of local anesthetics. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (12), pp. 721-727.

Partition (of aminoacylephedrines) Benzyl alcohol Role: PROC (Process) (sepn. of

Schönenberger, Helmut and Brinkmann, Rolf (1966) Separation of organic bases by Craig partition. VI. Correlations between the configuration and the phase distribution behavior of aminoacylephedrines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 229 (11), pp. 952-965.

partition between aq. solns. and org. solvents in relation to) Partition (of N

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Separation of organic bases by Craig distribution. III. Distribution behavior of diastereoisomeric N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamines. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297 (1), pp. 51-58.

pathology *Mammary Neoplasms

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

pathology *Organoplatinum Compounds: TU

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

pathology Carcinoma

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

pathology Cell Line Drug Screening Assays

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

pathology Humans *Interferons: AD

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

Pharmaceutical *Ephedrine *Research 0 (Anesthetics

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

pharmaceutical ephedrine experimental lab study *Amphetamine *Anesthetics

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Synthesis and Purification of Isomeric Aminoacylephedrine, a New Class of Local Anesthetics. 5. On the Separation of Organic Bases by the Craig Distribtion. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 297, pp. 721-727.

Pharmaceutical dosage forms (hydrosols

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

pharmacology *Antineoplastic Combined Chemotherapy Protocols: TU

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

pharmacology *Colony-Forming Units Assay Freezing Mice Tissue Preservation *Tumor Cells

Krischke, W. and Hartmann, R. and Schneider, M. and Schönenberger, Helmut (1988) A simple method of delayed processing of tumor tissue in a soft agar clonogenic assay. Journal of cancer research and clinical oncology 114 (2), pp. 170-176.

pharmacology Breast Neoplasms: PA

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

pharmacology Mammary Neoplasms

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

pharmacy - sterilization

Schönenberger, Helmut (1948) Über die Sterilisation in Öl gelöster Pharmaka. Süddeutsche Apotheker-Zeitung: pharmazeutisches Wochenblatt aus Württemberg 88 (8), p. 223.

phenylalanylaminophenylpropane prepn pharmacokinetics aminophenylpropane deriv pharmacokinetics amphetamine

Beck, D. and Hoelzl, J. and Schönenberger, Helmut (1981) Studies of pharmacokinetics and metabolic behavior of N-L-phenylalanyl-L-2-amino-1-phenylpropane. Arzneimittel-Forschung = Drug research 31 (10), pp. 1726-1731.

phenylpyridylbutene pyridylbutene alkoxyphenyl tamoxifen diphenylpyridylbutene analog

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 1. Synthesis. Archiv der Pharmazie 324 (4), pp. 223-229.

piperidino acetonitriles acetonitriles piperidino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. VI. Reactions of aliphatic-substituted alpha -aminoacetonitriles with metallic sodium in toluene. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (8), pp. 610-617.

piperidino acetonitriles Na ammonia acetonitriles piperidino Na ammonia ammonia Na piperidino acetonitriles sodium ammonia piperidino acetonitriles nitriles aceto piperidino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions with alpha -aminonitriles. VIII. Mode of reaction of alpha -aminoacetonitriles and metallic sodium in liquid ammonia. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (12), pp. 897-899.

platinum prepn.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

platinum compd. as

Schneider, M. R. and Schiller, C. D. and Humm, A. and Spruss, T. and Schönenberger, Helmut and Amselgruber, W. and Sinowatz, F. (1989) [1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): an endocrine-active platinum complex with a specific prostatic tumor-inhibiting activity. The prostate 15 (2), pp. 135-148.

platinum complex antitumor platinated DNA

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

platinum complex inhibition of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

platinum complex prepn stability neoplasm inhibition

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

platinum complexes

Gust, Ronald and Schönenberger, Helmut (1993) Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. European journal of medicinal chemistry 28 (2), pp. 103-115.

platinum complexes prepn. and stereoselectivity in antitumor activity of [1

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

platinum complexes antitumor effects and binding to mammary) Mammary gland (neoplasm

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

platinum complexes antitumor effects and binding to mammary) Neoplasm inhibitors (platinum complexes as

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

platinum complexes cytotoxicity in relation to binding to) platinum complex antitumor mammary estrogen receptor

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

platinum complexes interaction with

Schönenberger, Helmut and Wappes, B. and Jennerwein, M. and Berger, M. (1984) Development of selective, active platinum complexes. Contributions to oncology = Beiträge zur Onkologie 18 (Resistenzprobl. Chemo-Radiother. Malig. Tumoren), pp. 48-57.

platinum complexes of diaminoethanes as

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

platinum complexes with pyridylmethylamines) cytotoxicity platinum pyridylmethylamine complex aminepyridylmethyl platinum complex

Brunner, Henri and Dafinger, Willi and Schönenberger, Helmut (1989) Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma. Inorganica chimica acta 156 (2), pp. 291-301.

platinum complexes with pyridylmethylamines) Neoplasm inhibitors (mammary gland carcinoma

Brunner, Henri and Dafinger, Willi and Schönenberger, Helmut (1989) Synthesis of platinum dichloride complexes of pyridylmethylamine ligands and their activity against hormone-dependent mammary carcinoma. Inorganica chimica acta 156 (2), pp. 291-301.

platinum cycloalkylamine chloro antitumor prepn structure

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

platinum hydroxyphenylethylenediamine diastereomeric complexes as) crystal structure platinum hydroxyphenylethylenediamine complex leukemia inhibitor platinum hydroxyphenylethylenediamine complex kinetics substitution halo platinum hydroxyphenylethylenediamine complex platinum hydroxyphenylethylenediamine structure substitution kinetics

Gust, Ronald and Schönenberger, Helmut and Kritzenberger, Juergen and Range, Klaus Juergen and Klement, Ulrich and Burgemeister, Thomas (1993) Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Inorganic chemistry 32 (26), pp. 5939-5950.

platinum sulfato or sulfopropionato complexes with diarylethylenediamines) antitumor agent platinum ethylenediamine sulfopropionato sulfato

Müller, Richard and Bednarski, Patrick J. and Schönenberger, Helmut (1992) (1,2-Diaryl-1,2-ethylenediamine)platinum(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with different types of coordination in the solid state, in solution and reactions with nucleophiles. Inorganica chimica acta 195 (1), pp. 77-87.

platinum sulfato or sulfopropionato complexes with diarylethylenediamines) Mammary gland (neoplasm

Müller, Richard and Bednarski, Patrick J. and Schönenberger, Helmut (1992) (1,2-Diaryl-1,2-ethylenediamine)platinum(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with different types of coordination in the solid state, in solution and reactions with nucleophiles. Inorganica chimica acta 195 (1), pp. 77-87.

platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells)

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

platinum-peptide ester complexes inhibition of

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

PREP (Preparation)

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1966) Synthesis of alkoxybenzhydryl akylamines, local anesthetics from Schiff bases and phenyllithium. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 299 (12), pp. 1031-1038.

PREP (Preparation) fluorophenylethylenediamine platinum complex ethylenediamine fluorophenyl platinum complex

Müller, Richard and Schickaneder, Edith and Jennerwein, Margaretha and Reile, Herta and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1991) Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis. Archiv der Pharmazie 324 (2), pp. 115-120.

PREP (Preparation) (arom. amide derivs.

Schönenberger, Helmut and Endres, W. (1976) Research on the mechanism of action of local anesthetics. Part 7: Synthesis of N-aminoacyl-2,6-dimethylaniline, - benzylamine and -2-phenylethylamine enantiomers. Pharmazie 31 (1), pp. 30-32.

PREP (Preparation) (bis(difluorosalicylidene)diphenylethylenediamine

Müller, Richard and Schickaneder, Edith and Jennerwein, Margaretha and Reile, Herta and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1991) Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis. Archiv der Pharmazie 324 (2), pp. 115-120.

PREP (Preparation) (carboxylic acid

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

PREP (Preparation) (di-

Gust, Ronald and Schönenberger, Helmut (1993) Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. European journal of medicinal chemistry 28 (2), pp. 103-115.

PREP (Preparation) (diamines

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

PREP (Preparation) (mammary gland

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

PREP (Preparation) (N-phthalyl

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

PREP (Preparation) (neoplasm

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

PREP (Preparation) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its Estrogen receptors Role: PRP (Properties) (prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) Receptors Role: PRP (Properties) (estrogen

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

PREP (Preparation) (transition metal complexes

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

prepn.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

prepn. and acid hydrolysis of) Amines Role: SPN (Synthetic preparation)

Müller, Richard and Schickaneder, Edith and Jennerwein, Margaretha and Reile, Herta and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1991) Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis. Archiv der Pharmazie 324 (2), pp. 115-120.

prepn. and anti-mammary tumor activity of) antitumor activity platinum hydroxyphenylethylenediamine complex amine hydroxyphenylethylenedi platinum complex

Gust, Ronald and Schönenberger, Helmut (1993) Synthesis and evaluation of the anti-mammary tumor activity and of the estrogenic side effects of [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. European journal of medicinal chemistry 28 (2), pp. 103-115.

prepn. and antitumor activity of) Cytotoxic agents Neoplasm inhibitors (dichloro(amino acid)platinum complexes) Alcohols Role: RCT (Reactant)

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

prepn. and cytotoxicity and estrogen receptor-binding activity of) Receptors Role: BIOL (Biological study) (for estrogen

Karl, Johann and Gust, Ronald and Spruss, Thilo and Schneider, Martin R. and Schönenberger, Helmut and Engel, Juergen and Wrobel, Karl Heinz and Lux, Franz and Trebert-Haeberlin, Susanne (1988) Ring-substituted [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes: compounds with a selective effect on the hormone-dependent mammary carcinoma. Journal of medicinal chemistry 31 (1), pp. 72-83.

prepn. and estrogenic activity of (dichlorohydroxybenzyl)amine and its platinum complexes) estrogen activity dichlorohydroxybenzylamine platinum complex

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

prepn. of

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

prepn. of fluorophenyl- and difluorophenyl(p platinum fluorophenylethylenediamine deriv diastereomer prepn antitumor antitumor breast platinum fluorophenylethylenediamine deriv diastereomer

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

prepn. of fluorophenyl- and difluorophenyl(ph Mammary gland Role: BAC (Biological activity or effector

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

prepn. of) amino acid amide xylyl phenylalkyl aniline dimethyl aminoacyl benzylamine aminoacyl phenethylamine aminoacyl

Schönenberger, Helmut and Endres, W. (1976) Research on the mechanism of action of local anesthetics. Part 7: Synthesis of N-aminoacyl-2,6-dimethylaniline, - benzylamine and -2-phenylethylamine enantiomers. Pharmazie 31 (1), pp. 30-32.

prevention & control Mice Receptors

Schwarz, W. and Hartmann, R. W. and Engel, J. and Schneider, M. R. and Schönenberger, Helmut (1989) Ester derivatives of the mammary-tumor-inhibiting antiestrogen 2,3-bis(2-fluoro-4-hydroxyphenyl)-2,3-dimethylbutane. Journal of cancer research and clinical oncology 115 (2), pp. 161-165.

PROC (Process) ([Aqua-1-(2

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

PROC (Process) (discrepancy between cytotoxicity and platinum accumulation and DNA platination in MCF-7 breast cancer cells treated with diaqua(diphenylethylenediamine) platinum(II) sulfates and cisplatin in MCF-7 human breast cancer cells) platinum compd cytotoxicity DNA platination tumor diaquadiphenylethylenediamine platinum cytotoxicity DNA platination tumor

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

PROC (Process) (estrogen

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

PROC (Process) (metab. of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

PROC (Process) (platinated DNA after treatment of cancer cells with new platinum complexes)

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

PROC (Process) (platinum complexes mol.-mech. and quantum chem. study of species involved in hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes) amminechloroplatinum complex hydrolysis transition state simulation ethylenediaminechloro platinum complex hydrolysis mol mechanic EHMO amminechloroplatinum complex hydrolysis transition state

Nikolov, G. S. and Trendafilova, N. and Georgieva, I. and Schönenberger, Helmut and Gust, R. and Kritzenberger, J. and Yersin, H. (1997) Molecular mechanical and quantum chemical study of the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes. Part 2. Simulated transition states. Monatshefte für Chemie 128 (5), pp. 443-474.

PROC (Process) (redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Estrogens Role: BSU (Biological study

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

prostatic tumor inhibition in relation to) Prostate gland (neoplasm

Schneider, M. R. and Spruss, Thilo and Schiller, C. D. and Humm, A. and Schönenberger, Helmut (1988) Selective prostatic tumor inhibiting effect of an endocrine-active platinum complex. Progress in cancer research and therapy 35 (Horm. Cancer 3), pp. 509-513.

protein formation inhibition as mechanism of action of) protein formation antitumor platinum

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

PRP (Properties)

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Nikolov, G. S. and Trendafilova, N. and Georgieva, I. and Schönenberger, Helmut and Gust, R. and Kritzenberger, J. and Yersin, H. (1997) Molecular mechanical and quantum chemical study of the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)-dichloroplatinum(II) complexes. Part 2. Simulated transition states. Monatshefte für Chemie 128 (5), pp. 443-474.

quant.)

Schönenberger, Helmut and Thies, Heinrich and Borah, K. (1959) Quantitative separation of amine mixtures by Craig partition. Naturwissenschaften 46, pp. 144-145.

racemization in) phthalyl amino acid substitution amino acid racemization carbethoxyphthalimide substitution racemization phthalyl amino acid

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

racemization in) Racemization (in substitution reactions of amino acids with N-carbethoxyphthalimide) Substitution reaction (of N-carbethoxyphthalimide with amino acids

Schönenberger, Helmut and Endres, W. (1976) Studies on the mode of action of local anesthetics. Part 8. Studies on the preparation of the enantiomeric N-phthalylaminocarboxylic acids. Pharmazie 31 (11), pp. 811-813.

RACT (Reactant or reagent) (aliph.

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

RACT (Reactant or reagent) (alkynyl and alkyl

Thies, Heinrich and Schönenberger, Helmut and Beutel, R. (1972) Reactions of alpha -aminonitriles. IX. Reaction of alpha -aminonitriles with alkynyl and alkyl Grignard compounds. Archiv der Pharmazie 305 (1), pp. 18-26.

RACT (Reactant or reagent) (alpha -amino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. VII. Dimer exchange products of aromatic substituted aminonitriles. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (11), pp. 803-807.

RACT (Reactant or reagent) (alpha -amino) aminonitrile reaction alkyne Grignard arylalkyne amino nitrile amino reaction alkyne

Thies, Heinrich and Schönenberger, Helmut and El-Zanaty, M. (1972) Reactions of alpha -amino nitriles. 10. Synthesis of 1-amino-1-aryl-2-alkynes with cholinergic and cholinolytic properties. Arzneimittel-Forschung = Drug research 22 (7), pp. 1138-1144.

RACT (Reactant or reagent) (amino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. III. Reactions of alpha -aminonitriles and Grignard reagents. Effect of the degree of branching and chain length on the course of the reactions. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (1), pp. 30-42.

RACT (Reactant or reagent) (amino) piperidinoacetonitrile Grignard adduct adduct Grignard piperidinoacetonitrile Grignard adduct piperidinoacetonitrile Dimerization piperidinoacetonitrile amino dipiperidinocrotonitrile dipiperidinocrotonitrile amino

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. V. Adduct formation and dimerization of alpha -piperidinoacetonitrile in reaction with butylmagnesium chloride. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (3), pp. 168-174.

RACT (Reactant or reagent) (aminoacylation of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

RACT (Reactant or reagent) (and inhibitors

Hartmann, Rolf W. and Heindl, Aledander and Schönenberger, Helmut (1984) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 2. Synthesis and estrogen receptor binding affinity of 4,4'-, 5,5'-, and 6,6'-disubstituted metahexestrols. Journal of medicinal chemistry 27 (5), pp. 577-585.

RACT (Reactant or reagent) (antagonists

Hartmann, Rolf W. and Vom Orde, Hans Dieter and Schönenberger, Helmut (1990) Antiestrogenic N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamides: influence of hydrophobic groups substituted in the ortho position of the benzamide fragment on activity. Archiv der Pharmazie 323 (2), pp. 73-78.

RACT (Reactant or reagent) (for estrogens

Schneider, Martin R. and von Angerer, Erwin and Schönenberger, Helmut (1982) 5-Acetoxy-2-(3-acetoxyphenyl)-3-ethyl-1-methyl-1H-indene: a new mammary tumor inhibiting compound. European journal of medicinal chemistry 17 (3), pp. 245-248.

RACT (Reactant or reagent) (Mannich reaction with bis(chloroethyl)amine

Schönenberger, Helmut and Bindl, L. and Adam, A. (1973) Cytostatics. 21. Synthesis and carcinostatic action of N-[bis(2-chloroethyl)aminomethyl]amides. Archiv der Pharmazie 306 (1), pp. 64-75.

RACT (Reactant or reagent) (prepn. and esterification of

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

RACT (Reactant or reagent) (prepn. and reaction of

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1966) Synthesis of alkoxybenzhydryl akylamines, local anesthetics from Schiff bases and phenyllithium. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 299 (12), pp. 1031-1038.

RACT (Reactant or reagent) (prepn. properties and reactions of) review amine heterocyclic amine review arom amine review aliph amine review

Schneider, W. and Hoyer, J. and Ehrenstein, W. and Haller, R. and Haensel, W. and Lehmann, K. and Roth, H. J. and Schönenberger, Helmut and Camerino, B. (1975) Amines. Method. Chim. 6, pp. 439-589.

RACT (Reactant or reagent) (receptor for

Hartmann, Rolf W. and Heindl, Alexander and Schneider, Martin R. and Schönenberger, Helmut (1986) Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes. Journal of medicinal chemistry 29 (3), pp. 322-328.

reaction of

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

reaction with aminonitriles) piperidino alkyne alkane piperidino parasympatholytic

Thies, Heinrich and Schönenberger, Helmut and Beutel, R. (1972) Reactions of alpha -aminonitriles. IX. Reaction of alpha -aminonitriles with alkynyl and alkyl Grignard compounds. Archiv der Pharmazie 305 (1), pp. 18-26.

reaction with Mg-MgI2 mixt.) Magnesium Role: PREP (Preparation) Magnesium Magnesium iodide (reaction with N-benzylidene alkyl amines)

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reactions of Schiff bases. III. Formation of ethylenediamine derivatives from benzylidenealkylamines and magnesium-magnesium iodide mixtures. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 248-256.

receptor binding in relation to) Neoplasm inhibitors (tetramethylbis(hydroxyphenyl)ethanes) Molecular structure-biological activity relationship (antiestrogenic

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

Receptors Role: BIOL (Biological study) (estrogen

Schönenberger, Helmut and Wappes, B. and Jennerwein, M. and Berger, M. (1984) Development of selective, active platinum complexes. Contributions to oncology = Beiträge zur Onkologie 18 (Resistenzprobl. Chemo-Radiother. Malig. Tumoren), pp. 48-57.

Receptors Role: BIOL (Biological study) (for estrogen

Hartmann, Rolf W. and Schwarz, Walter and Schönenberger, Helmut (1983) Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols. Journal of medicinal chemistry 26 (8), pp. 1137-1144.

Receptors Role: BIOL (Biological study) (for estrogens

Otto, Angela M. and Faderl, Michael and Schönenberger, Helmut (1991) Dissociation of estrogenic and cytotoxic properties of an estrogen receptor-binding platinum complex in human breast cancer cell lines. Cancer research 51 (12), pp. 3217-3223.

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

Seidenberger, Horst and Kranzfelder, Gerhard and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth, Michael (1981) Studies on the mammary tumor inhibiting effect of cis-bis(glycylglycin ethyl ester)platinum(II) chloride. Archiv der Pharmazie 314 (11), pp. 955-967.

Receptors Role: PROC (Process) (for estrogen

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) Molecular structure-biological activity relationship (estrogenic

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Mammary gland (neoplasm

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Molecular structure-biological activity relationship (neoplasm-inhibiting

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) Neoplasm inhibitors (mammary gland

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

redn. of estrogenic side effects of mammary tumor-inhibiting drug [(chlorohydroxyphenyl)ethylenediamine]chloroplatinum(II) by variation of ring substituents) phenylethyleneamine platinum complex mammary antitumor estrogenic mammary cancer inhibitor phenylethyleneamine platinum complex

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

redn. of)

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reduction of benzylidene alkylamines with activated aluminum in alcoholic solution. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 373-375.

Reduction (of alpha -amino nitriles) Nitriles (redn. of)

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1965) Reduction of alpha -amino nitriles with metallic sodium in toluene. Tetrahedron letters (3), pp. 163-166.

Reduction (of Schiff bases by activated aluminum

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1967) Cytostatic compounds. V. Mechanism of the formation of diphenylethylenediamines from benzylidenealkylamines and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 300 (3), pp. 258-268.

Resolution (by countercurrent extn.) Extraction (countercurrent

Schönenberger, Helmut (1958) The separation of N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamine dihydrochloride into its meso and racemic forms by Craig's partition method. Chemische Berichte 91, pp. 862-864.

Resolution (of amino acids

Schönenberger, Helmut and Brinkman, R. and Bamann, E. (1963) Resolution of N-(DL-N,N-dimethylalanyl)-L-y-ephedrine into its stereoisomeric forms of Craig partition. The possibility of resolution of racemic amino acids into optical isomers using countercurrent methods. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 296, pp. 33-37.

resolution of optical isomers by) Isomerism (diastereo-

Schönenberger, Helmut (1958) The separation of N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamine dihydrochloride into its meso and racemic forms by Craig's partition method. Chemische Berichte 91, pp. 862-864.

Ribonucleic acids Role: RCT (Reactant)

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael (1983) Mechanism of action of cis-bis(glycylglycineethyl ester)platinum(II) chloride - effect on protein biosynthesis. Archiv der Pharmazie 316 (12), pp. 1007-1012.

Schiff bases (Grignard reaction of

Thies, H. and Schönenberger, Helmut and Zeller, A. (1965) Reactions of Schiff bases. XI. Effect of heavy metal halides on the reaction between Grignard-type compounds and Schiff bases. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (1), pp. 26-33.

Schiff bases (Grignard reactions of

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1959) The effect of manganous salts on the reaction of Schiff bases with Grignard reagents. Naturwissenschaften 46, p. 378.

Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases)

Schönenberger, Helmut and Thies, Heinrich and Zeller, A. and Borah, K. (1961) The influence of manganese(II) chloride on the reaction between Grignard compounds and Schiff bases. Naturwissenschaften 48, pp. 129-130.

Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases) Amines (N-benzylidene

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reactions of Schiff bases. III. Formation of ethylenediamine derivatives from benzylidenealkylamines and magnesium-magnesium iodide mixtures. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 248-256.

Schiff bases (Grignard reactions of) Grignard reaction (with Schiff bases) Magnesium (reaction with N-benzylideneethylamine)

Thies, Heinrich and Schönenberger, Helmut (1956) The reaction of Grignard compounds with Schiff bases. I. The formation of ethylenediamine derivatives. Chemische Berichte 289, pp. 1918-1921.

Schiff bases (Grignard reactions of) Substituents (dimerization of Schiff bases in presence of Grignard reagents in relation to) Polymerization (dimerization of Schiff bases

Thies, Heinrich and Schönenberger, Helmut (1956) The reaction of Grignard compounds with Schiff bases. II. The dimerization of Schiff bases in dependence on the substituents on the nitrogen and on the nature of the Grignard reagent. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 289 (8), pp. 408-417.

Schiff bases (reactions of) Schiff bases (reactions of

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reactions of Schiff bases. V. The conversion of benzyl idenearylamines with Mg-MgI2 mixtures. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 620-627.

Schiff bases Role: SPN (Synthetic preparation)

Müller, Richard and Schickaneder, Edith and Jennerwein, Margaretha and Reile, Herta and Spruss, Thilo and Engel, Juergen and Schönenberger, Helmut (1991) Tumor inhibiting [1,2-bis(difluorophenyl)ethylenediamine]dichloroplatinum(II) complexes. I. Synthesis. Archiv der Pharmazie 324 (2), pp. 115-120.

screening of

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthard (1984) cis-Dichloro[bis(oligopeptide ester)]platinum(II) complexes, study on the detection of antitumor activity with bacteriological test systems. Archiv der Pharmazie 317 (9), pp. 760-767.

sepn. by countercurrent extn.)

Schönenberger, Helmut (1958) The separation of N,N'-dibutyl-alpha ,alpha '-diphenylethylenediamine dihydrochloride into its meso and racemic forms by Craig's partition method. Chemische Berichte 91, pp. 862-864.

solvent effect on)

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1965) Effect of solvents on the reduction between Schiff bases and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (9), pp. 635-638.

solvent effect on) Schiff bases (redn. of

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1965) Effect of solvents on the reduction between Schiff bases and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (9), pp. 635-638.

Solvents (in Schiff base redn. by Al) Reduction (of Schiff bases

Schönenberger, Helmut and Thies, Heinrich and Rappl, A. (1965) Effect of solvents on the reduction between Schiff bases and activated aluminum. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 298 (9), pp. 635-638.

SPN (Synthetic preparation)

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Brunner, Henri and Hankofer, Peter and Holzinger, Ulrich and Treittinger, Barbara and Schönenberger, Helmut (1990) Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands. European journal of medicinal chemistry. 25 (1), pp. 35-44.

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1966) Synthesis of alkoxybenzhydryl akylamines, local anesthetics from Schiff bases and phenyllithium. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 299 (12), pp. 1031-1038.

stability

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

Gust, Ronald and Bernhardt, Günther and Spruss, Thilo and Krauser, Rudolf and Koch, Marion and Schönenberger, Helmut and Bauer, Kurt-Heinz and Schertl, Sabine and Lu, Zhi (1995) Development of a parenterally administrable hydrosol preparation of the \"third generation platinum complex\" [(+-)-1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II). Part 1. Preparation and studies on the stability and antitumor activity. Archiv der Pharmazie (Weinheim, Germany) 328 (9), pp. 645-653.

stilbene derivs. antagonism of) Estrogens Role: BIOL (Biological study) (receptor for

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

stilbene derivs. antagonism of) Neoplasm inhibitors (stilbene derivs. as) Mammary gland (neoplasm

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

stilbene derivs. as

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

stilbene derivs. binding by

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

stilbene derivs. inhibition of) Molecular structure-biological activity relationship (neoplasm-inhibiting

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. and Fortmeyer, H. P. (1982) Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha ,beta -dialkylstilbenes and of related stilbene oxides. Journal of medicinal chemistry 25 (2), pp. 141-145.

structure in relation to)

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

Kritzenberger, J and Bernhardt, Günther and Gust, Ronald and Pistor, Petra and Schönenberger, Helmut and Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), pp. 587-604.

structure in relation to) Bactericides Fungicides (aminoketones) Molecular structure-biological activity relationships (biocidal

Schönenberger, Helmut and Bastug, T. and Bindl, L. and Adam, Adelheid and Adam, Dieter and Petter, A. and Zwez, W. (1969) Action mechanism of antimicrobial beta -amino ketones. Pharmaceutica acta Helvetiae 44 (11), pp. 691-714.

structure in relation to) Conformation and Conformers (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes) Crystal structure (of [(halohydroxyphenyl)ethylenediamine]platinum(II) complexes

Gust, Ronald and Schönenberger, Helmut and Klement, Ulrich and Range, Klaus Juergen (1993) Aqua[1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine]sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring. II. Correlation of molecular structure and estrogenic activity of breast and prostate cancer inhibiting [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Archiv der Pharmazie 326 (12), pp. 967-976.

structure in relation to) Molecular structure-biological activity relationship (antidepressant

Beck, D. and Fink, K. and Hoelzl, J. and Krieglstein, J. and Petter, A. and Rieger, H. and Schönenberger, Helmut (1983) Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class. Arzneimittel-Forschung = Drug research 33 (3), pp. 404-410.

structure in relation to) Molecular structure-biological activity relationship (neoplasm-inhibiting

Schönenberger, Helmut and Wappes, Beate and Jennerwein, Margaretha and Berger, Martin (1984) Development of selectively acting platinum complexes. Cancer treatment reviews 11 (Suppl. A), pp. 125-130.

structure in relation to) Molecular structure-biological activity relationships (antimicrobial

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

structure platinum ethyl glycylglycinate chloro platinum peptide amino acid ester

Beck, Wolfgang and Bissinger, Herbert and Girnth-Weller, Michael and Purucker, Bernhard and Thiel, Gerhard and Zippel, Horst and Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut (1982) Metal complexes with biologically important ligands. XXI. Antitumor active cis-platinum(II) complexes with alpha -amino acid esters and peptide esters. Structure of cis-dichlorobis(glycylglycine ethyl ester)platinum(II). Chemische Berichte 115 (6), pp. 2256-2270.

structure-activity relations of) estrogenic platinum complex conformation

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

structure-activity relations of) Mammary gland (neoplasm

Gust, Ronald and Schönenberger, Helmut (1993) Mammary tumor inhibiting [1,2-bis(2,6-dihalo-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. III. Relationship between structure and estrogenic activity of the diamine ligands, their sulfatoplatinum(II) and diiodoplatinum(II) complexes. Archiv der Pharmazie 326 (7), pp. 405-413.

Structure-activity relationship (antitumor prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Antitumor agents Conformation Human Mammary gland (prepn. of platinum(II) chloro bis(fluorohydroxyphenyl)ethylenediamine complexes and their cytotoxic/estrogenic activity in breast cancer cells) Estrogen receptors Role: BSU (Biological study

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

structure-activity relationship of) Mammary gland (neoplasm

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

structure-activity relationship of) Molecular structure-biological activity relationship (neoplasm-inhibiting

Schertl, Sabine and Gust, Ronald and Müller, Richard and Spruss, Thilo and Schönenberger, Helmut (1992) Stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]platinum(II) complexes. Part III. Evaluation of the mammary tumor inhibiting properties. Archiv der Pharmazie 325 (2), pp. 113-118.

synthesis

Schertl, Sabine and Hartmann, Rolf W. and Batzl-Hartmann, Christine and Schlemmer, Richard and Spruß, Thilo and Bernhardt, Günther and Gust, Ronald and Schönenberger, Helmut (2001) 1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethanes--new biological response modifiers for the therapy of breast cancer. Synthesis and evaluation of estrogenic/antiestrogenic properties. Archiv der Pharmazie 334 (4), pp. 125-137.

targeting for aminoacyl-tRNA synthetases

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

targeting for aminoacyl-tRNA synthetases) Amino acids Role: BIOL (Biological study) (antagonist of

Laske, Reiner and Schönenberger, Helmut and Holler, Eggehard (1989) Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I. The antibacterial effect. Archiv der Pharmazie 322 (12), pp. 847-852.

tetramethylbis(fluorohydroxyphenyl)ethane for) fluorohydroxyphenylethane prepn neoplasm inhibitor antiestrogen fluorohydroxyphenylethane estrogen inhibitor fluorohydroxyphenylethane

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

tetramethylbis(fluorohydroxyphenyl)ethane for) Mammary gland Prostate gland (neoplasm

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

tetramethylbis(hydroxyphenyl)ethanes

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

tetramethylbis(hydroxyphenyl)ethanes binding by) Estrogens Role: BSU (Biological study

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

therapeutic use Breast Neoplasms: AN

Porzsolt, F. and Otto, A. M. and Trauschel, B. and Buck, C. and Wawer, A. W. and Schönenberger, Helmut (1989) Rationale for combining tamoxifen and interferon in the treatment of advanced breast cancer. Journal of cancer research and clinical oncology 115 (5), pp. 465-469.

therapeutic use Receptors

Engel, J. and Schumacher, W. and Schönenberger, Helmut (1986) Design of metallocenic drugs. IARC scientific publications (78), pp. 295-307.

therapeutic use Stereoisomerism Structure-Activity Relationship 0 (Antineoplastic Agents) 0 (Organoplatinum Compounds)

Jennerwein, M. and Wappes, B. and Gust, Ronald and Schönenberger, Helmut and Engel, J. and Seeber, S. and Osieka, R. (1988) Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes. Journal of cancer research and clinical oncology 114 (4), pp. 347-358.

therapy of

Engel, J. and Schönenberger, Helmut and Lux, F. and Hilgard, P. (1987) Estrophilic cisplatin derivatives. Cancer treatment reviews 14 (3-4), pp. 275-283.

thiourethanes antimicrobial antimicrobial thiourethanes urethanes dithio prepn cytostatic thiourethanes

Schönenberger, Helmut and Lippert, P. (1970) Cytostatics. 12. Synthesis of antimicrobial active dithiourethanes. Pharmazie 25 (12), pp. 734-736.

THU (Therapeutic use)

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

toward mammary tumors) Isomerism and Isomers (diastereo-

Gust, Ronald and Schönenberger, Helmut (1993) Breast cancer-inhibiting properties of leaving group derivatives of [1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II). European Journal of Medicinal Chemistry 28 (2), pp. 117-127.

Transition metal complexes Role: BAC (Biological activity or effector

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

treatment of

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

Schönenberger, Helmut and Hartmann, Rolf and Schneider, Martin and Schwarz, Walter and Engel, Juergen (1986) Preparation of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl)ethane derivatives and antitumor pharmaceuticals containing them.

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

Tuberculostatics (alkylbenzylamine) Molecular structure-biological activity relationship (tuberculostatic

Ruckdeschel, G. and Stransky, D. and Schönenberger, Helmut (1976) Studies of the correlation between structure and tuberculostatic effect of the benzylamine class. Pharmazie 31 (6), pp. 374-381.

Tuberculostatics (benzylamines as

Laske, Reiner and Meindl, Wolfgang and Holler, Eggehard and Schönenberger, Helmut (1989) Investigations on the mode of action of antimycobacterial benzylamines. Archiv der Pharmazie 322 (5), pp. 297-299.

Tuberculostatics (N-alkylbenzylamines) Mycobacterium (N-alkylbenzylamines sensitivity of) Molecular structure-biological activity relationship (tuberculostatic

Ruckdeschel, G. and Stransky, D. and Schönenberger, Helmut (1977) Antimycobacterial properties of N-alkylbenzylamines. Pharmazie 32 (2), pp. 119-122.

unclassified)

Gust, Ronald and Beck, Wolfgang and Jaouen, Gerard and Schönenberger, Helmut (2009) Optimization of cisplatin for the treatment of hormone dependent tumoral diseases Part.1. Use of steroidal ligands. Coordination Chemistry Reviews 253 (21-22), pp. 2742-2759.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (2005) [N-Ethyl- and [N,N'-Diethyl-1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II): Structure and Cytotoxic/Estrogenic Activity in Breast Cancer Cells. Journal of Medicinal Chemistry 48 (23), pp. 7132-7144.

Gust, Ronald and Faderl, Michael and Schönenberger, Helmut (2000) [Aqua-1-(2,6-dichloro-4-hydroxyphenyl)-2-phenylethylenediamine] sulfatoplatinum(II) complexes with variable substituents in the 2-phenyl ring 3. Investigation of breast cancer inhibiting properties. Journal of cancer research and clinical oncology 126 (11), pp. 647-654.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Gelbcke, Michael and Angermaier, Bernhard and Bachmann, Helmut and Krauser, Rudolf and Schönenberger, Helmut (1997) The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes. Inorganica chimica acta 264 (1-2), pp. 145-160.

Lux, Franz and Hollstein, Michael and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1996) Discrepancy between cytotoxicity, platinum accumulation, and DNA platination in MCF-7 breast cancer cells treated with diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and cisplatin. Biological Trace Element Research 53 (1-3), pp. 113-128.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Niebler, Karlheinz and Schönenberger, Helmut (1995) Investigation of the Configurational and Conformational Influences on the Hormonal Activity of 1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their Platinum(II) Complexes. 1. Synthesis, Estradiol Receptor Affinity, and Estrogenic Activity of Diastereomeric [N-Alkyl- and N,N'-Dialkyl-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) Complexes. Journal of Medicinal Chemistry 38 (12), pp. 2070-2079.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Karl, Johann and Faderl, Michael and Schönenberger, Helmut (1995) Reduction of the estrogenic side effects of the mammary tumor-inhibiting drug [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) by variation of ring substituents. Archiv der Pharmazie 328 (5), pp. 457-463.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1995) Third generation antitumor platinum(II) complexes of the [1-(fluoro/difluorophenyl)-2-phenylethylenediamine]platinum(II) type. Archiv der Pharmazie 328 (7-8), pp. 595-603.

Gust, Ronald and Schönenberger, Helmut (1994) Investigation of the Conformational influences on the estrogenic activity of 1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamines and of their platinum(II) complexes, II. Synthesis and studies on the estrogenic activity of cis- and trans[bis(2,6-dichloro-4-hydroxybenzylamine)]dihaloplatinum(II) complexes. Archiv der Pharmazie 327 (12), pp. 763-769.

Hollstein, Michael and Lux, Franz and Reile, Herta and Bernhardt, Günther and Schönenberger, Helmut (1993) NAA of platinated DNA after treatment of cancer cells with new platinum complexes. .

Schwarz, Walter and Hartmann, Rolf W. and Schönenberger, Helmut (1991) 1,2-Diphenyl-1-pyridylbut-1-enes - potential antiestrogens. Part 2. Biological evaluation. Archiv der Pharmazie 324 (4), pp. 231-234.

Hartmann, Rolf W. and Schwarz, Walter and Heindl, Alexander and Schönenberger, Helmut (1985) Ring-substituted 1,1,2,2-tetraalkylated 1,2-bis(hydroxyphenyl)ethanes. 4. Synthesis, estrogen receptor binding affinity, and evaluation of antiestrogenic and mammary tumor inhibiting activity of symmetrically disubstituted 1,1,2,2-tetramethyl-1,2-bis(hydroxyphenyl)ethanes. Journal of medicinal chemistry 28 (9), pp. 1295-1301.

Seidenberger, Horst and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Lux, Franz and Zeisler, Rolf (1983) Studies on the mechanism activity of cis-bis(glycylglycine ethyl ester)platinum(II) chloride - action on nucleic acid metabolism. Archiv der Pharmazie 316 (2), pp. 170-181.

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

Schönenberger, Helmut and Kranzfelder, G. and Schneider, M. (1981) Development of new anti-estrogens and their effects on DMBA-induced hormone dependent mammary tumors of the rat. In: Bastert, Gunther, (ed.) Thymusaplastic nude mice and rats in clinical oncology: proceedings of the symposium at the Klinikum der Johann-Wolfgang-Goethe-Universität. Frankfurt am Main, June 11-15, 1979. Fischer, Stuttgart, pp. 205-211. ISBN 3-437-10683-X; 0-89574-154-7.

Hartmann, Rolf W. and Buchborn, Helga and Kranzfelder, Gerhard and Schönenberger, Helmut and Bogden, Arthur E. (1981) Potential antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,2-dialkyl-1,2-bis(3'-hydroxyphenyl)ethanes. Journal of medicinal chemistry 24 (10), pp. 1192-1197.

Schönenberger, Helmut and Bastug, T. (1971) Cytostatic drugs. 10. Relations between stability and antimicrobial activity of beta-aminoketones. Arzneimittel-Forschung = Drug research 21 (1), pp. 68-75.

Schönenberger, Helmut and Bastug, T. and Adam, D. (1969) Cytostatics. VIII. Relations between chemical constitution and antimicrobial activity in beta -aminoketones. Arzneimittel-Forschung = Drug research 19 (7), pp. 1082-1091.

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

USES (Uses) (anesthetic activity of

Schönenberger, Helmut and Fuchsberger, K. D. and Petter, Alfred and Brinkmann, Rolf (1967) Interrelations between drug and receptor for N-aminoacylephedrine local anesthetics. Pharmaceutica acta Helvetiae 42 (3), pp. 163-176.

Uterus (estrogen receptors of

Schneider, Martin R. and Schönenberger, Helmut and Michel, Ralf T. (1982) Mammary tumor inhibiting [(1,2-diethyl-1,2-cyclopropanediyl) bis-(phenyl)] diacetates. European journal of medicinal chemistry 17 (6), pp. 491-495.

water soly.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

Gust, Ronald and Krauser, Rudolf and Schmid, Beate and Schönenberger, Helmut (1998) Synthesis and antitumor activity of [1,2-bis(4-fluorophenyl)ethylenediamine][dicarboxylato]platinum(II) complexes. Archiv der Pharmazie 331 (1), pp. 27-35.

with Al amalgam and with Mg-MgI2 mixts.) Schiff bases (reactions of) Magnesium Magnesium iodide (reaction with ketimines)

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1960) Reactions of Schiff bases. VIII. The reactions of ketimines with Mg-MgI2 mixture and with aluminum amalgam. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaf 293, pp. 67-73.

with Al catalyst

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

with Al catalyst)

Schönenberger, Helmut and Brinkmann, R. and Bamann, E. (1964) Reduction of Schiff bases with activated aluminum. Kongr. Pharm. Wiss, Vortr. Originalmitt., 23.Muenster, (Westfalen), Ger. 1963, pp. 321-329.

with amino acid platinum complexes in hydrochloric acid presence) chloro amino acid platinum cytostatic

Schönenberger, Helmut and Bissinger, Herbert and Thiel, Gerhard and Zippel, Horst and Beck, Wolfgang (1983) cis-Dichloroamino acid platinum(II) complexes.

with Mg-MgI2 mixts.) Magnesium Magnesium iodide (reaction with Schiff bases)

Thies, Heinrich and Schönenberger, Helmut and Bauer, K. H. (1958) Reactions of Schiff bases. V. The conversion of benzyl idenearylamines with Mg-MgI2 mixtures. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 291, pp. 620-627.

with phenyllithium) AMINES BENZHYDRYL ALKYL BENZHYDRYL ALKYL AMINES ALKYL BENZHYDRYL AMINES

Thies, Heinrich and Schönenberger, Helmut and Borah, K. (1966) Synthesis of alkoxybenzhydryl akylamines, local anesthetics from Schiff bases and phenyllithium. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 299 (12), pp. 1031-1038.

with platinum complexes of diaminoethanes

Brunner, Henri and Schmidt, Manfred and Unger, Gerfried and Schönenberger, Helmut (1985) Inhibition of cell growth and [3H]-thymidine incorporation in human mammary carcinoma cell line MDA-MB 231 by platinum(II) chloride-complexes of 1,2-diaminoethanes derived from amino acids. European journal of medicinal chemistry 20 (6), pp. 509-512.

with platinum-peptide ester complexes

Seidenberger, Horst and Wappes, Beate and Schönenberger, Helmut and Beck, Wolfgang and Girnth-Weller, Michael and Ruckdeschel, Gotthart (1983) Relations between structure and antitumor activity of cis-dichloro[bis(oligopeptide ester)platinum(II)] complexes. Archiv der Pharmazie 316 (2), pp. 121-131.

with sodium in presence of toluene) nitriles amino dimerization amino nitriles dimerization benzyl amines dimers dimers amines benzyl

Thies, Heinrich and Schönenberger, Helmut and Qasba, P. K. (1969) Reactions of alpha -aminonitriles. VII. Dimer exchange products of aromatic substituted aminonitriles. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft 302 (11), pp. 803-807.

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