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Publikationen von Spang, Rainer

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Anzahl der Einträge: 145.

2024

Rupp, Kevin, Schill, Rudolf , Süskind, Jonas, Georg, Peter, Klever, Maren, Lösch, Andreas, Grasedyck, Lars, Wettig, Tilo und Spang, Rainer (2024) Differentiated uniformization: a new method for inferring Markov chains on combinatorial state spaces including stochastic epidemic models. Computational Statistics.

Schill, Rudolf , Klever, Maren, Rupp, Kevin, Hu, Y. Linda, Lösch, Andreas, Georg, Peter, Pfahler, Simon, Vocht, Stefan, Hansch, Stefan, Wettig, Tilo , Grasedyck, Lars und Spang, Rainer (2024) Reconstructing Disease Histories in Huge Discrete State Spaces. KI - Künstliche Intelligenz.

2023

Schill, Rudolf, Klever, Maren, Lösch, Andreas, Hu, Y. Linda , Vocht, Stefan, Rupp, Kevin, Grasedyck, Lars, Spang, Rainer und Beerenwinkel, Niko (2023) Overcoming Observation Bias for Cancer Progression Modeling. bioRxiv. (Eingereicht)

Leich, E., Brodtkorb, Marianne, Schmidt, T., Altenbuchinger, Michael, Lingjærde, Ole Christian, Lockmer, S., Holte, H., Nedeva, T., Grieb, T., Sander, B., Sundström, C., Spang, Rainer, Kimby, E. und Rosenwald, A. (2023) Gene expression and copy number profiling of follicular lymphoma biopsies from patients treated with first-line rituximab without chemotherapy. Leukemia & lymphoma, S. 1-11. Volltext nicht vorhanden.

Buck, Lena, Schmidt, Tobias, Feist, Maren, Schwarzfischer, Philipp, Kube, Dieter, Oefner, Peter J. , Zacharias, Helena U., Altenbuchinger, Michael , Dettmer, Katja , Gronwald, Wolfram und Spang, Rainer (2023) Anomaly detection in mixed high dimensional molecular data. Bioinformatics 39 (8), btad501.

Rösler, Wiebke, Altenbuchinger, Michael, Baeßler, Bettina, Beissbarth, Tim, Beutel, Gernot, Bock, Robert, von Bubnoff, Nikolas, Eckardt, Jan-Niklas, Foersch, Sebastian, Loeffler, Chiara M L, Middeke, Jan Moritz, Mueller, Martha-Lena, Oellerich, Thomas, Risse, Benjamin, Scherag, André, Schliemann, Christoph, Scholz, Markus, Spang, Rainer , Thielscher, Christian, Tsoukakis, Ioannis und Kather, Jakob Nikolas (2023) An overview and a roadmap for artificial intelligence in hematology and oncology. Journal of cancer research and clinical oncology.

2022

Georg, Peter, Grasedyck, Lars, Klever, Maren, Schill, Rudolf , Spang, Rainer und Wettig, Tilo (2022) Low-rank tensor methods for Markov chains with applications to tumor progression models. Journal of Mathematical Biology 86 (7).

Sorrentino, Antonio, Menevse, Ayse Nur , Michels, Tillmann, Volpin, Valentina, Durst, Franziska Christine, Sax, Julian, Xydia, Maria, Hussein, Abir, Stamova, Slava, Spoerl, Steffen, Heuschneider, Nicole, Muehlbauer, Jasmin, Jeltsch, Katharina Marlene, Rathinasamy, Anchana, Werner-Klein, Melanie, Breinig, Marco, Mikietyn, Damian, Kohler, Christian, Poschke, Isabel, Purr, Sabrina, Reidell, Olivia, Martins Freire, Catarina, Offringa, Rienk, Gebhard, Claudia, Spang, Rainer, Rehli, Michael, Boutros, Michael , Schmidl, Christian , Khandelwal, Nisit und Beckhove, Philipp (2022) Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation. Journal for immunotherapy of cancer 10 (5), e004258.

Hassel, Jessica C., Schank, Timo E., Smetak, Heiko, Mühlbauer, Jasmin, Salzmann, Martin, Machiraju, Devayani, Menzer, Christian, Lang, Kristin, König, Laila, Haefner, Matthias F., Hülsmeyer, Ingrid, Kohler, Christian , Spang, Rainer , Enk, Alexander, Debus, Jürgen und Beckhove, Philipp (2022) Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA). Oncoimmunology 11 (1), S. 2066609.

Schrod, Stefan, Schäfer, Andreas, Solbrig, Stefan, Lohmayer, Robert, Gronwald, Wolfram , Oefner, Peter J. , Beißbarth, Tim, Spang, Rainer , Zacharias, Helena U. und Altenbuchinger, Michael (2022) BITES: Balanced Individual Treatment Effect for Survival data. arXiv. (Eingereicht)

2021

Siska, Peter J., Decking, Sonja-Maria, Babl, Nathalie, Matos, Carina, Bruss, Christina, Singer, Katrin, Klitzke, Jana, Schön, Marian, Simeth, Jakob , Köstler, Josef, Siegmund, Heiko, Ugele, Ines, Paulus, Michael, Dietl, Alexander, Kolodova, Kristina, Steines, Louisa , Freitag, Katharina, Peuker, Alice, Schönhammer, Gabriele, Raithel, Johanna, Graf, Bernhard, Geismann, Florian, Lubnow, Matthias, Mack, Matthias, Hau, Peter, Bohr, Christopher, Burkhardt, Ralph , Gessner, Andre, Salzberger, Bernd, Wagner, Ralf, Hanses, Frank, Hitzenbichler, Florian, Heudobler, Daniel, Lüke, Florian, Pukrop, Tobias, Herr, Wolfgang, Wolff, Daniel, Spang, Rainer, Poeck, Hendrik, Hoffmann, Petra, Jantsch, Jonathan, Brochhausen, Christoph, Lunz, Dirk, Rehli, Michael, Kreutz, Marina und Renner, Kathrin (2021) Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone. Journal of Clinical Investigation 131 (22), e148225. Zugang zum Volltext eingeschränkt.

Richter, Julia , John, Katharina, Staiger, Annette M., Rosenwald, Andreas, Kurz, Katrin, Michgehl, Ulf, Ott, German, Franzenburg, Sören, Kohler, Christian , Finger, Jasmin, Oschlies, Ilske, Paul, Ulrike, Siebert, Reiner, Spang, Rainer , Burkhardt, Birgit und Klapper, Wolfram (2021) Epstein-Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features. British journal of haematology 196 (3), S. 681-689.

Croci, G. A., Au-Yeung, R. K. H., Reinke, S., Staiger, A. M., Koch, K., Oschlies, I., Richter, J., Poeschel, V., Held, G., Loeffler, M., Trümper, L., Rosenwald, A., Ott, G., Spang, Rainer, Altmann, B., Ziepert, M. und Klapper, W. (2021) SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC rearrangement and double-/triple-hit status. Annals of Oncology. Volltext nicht vorhanden.

Jachimowicz, Ron D., Klapper, Wolfram, Glehr, Gunther , Müller, Horst, Haverkamp, Heinz, Thorns, Christoph, Hansmann, Martin Leo, Möller, Peter, Stein, Harald, Rehberg, Thorsten, von Tresckow, Bastian, Reinhardt, H. C., Borchmann, Peter, Chan, Fong Chun, Spang, Rainer, Scott, David W., Engert, Andreas, Steidl, Christian, Altenbuchinger, Michael und Rosenwald, Andreas (2021) Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP. Leukemia.

Linck-Paulus, Lisa , Lämmerhirt, Lisa, Völler, Daniel, Meyer, Katharina, Engelmann, Julia C. , Spang, Rainer, Eichner, Norbert, Meister, Gunter, Kuphal, Silke und Bosserhoff, Anja Katrin (2021) Learning from Embryogenesis—A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development. Journal of Clinical Medicine 10 (11), S. 2259.

Nordmo, Carmen, Glehr, Gunther, Altenbuchinger, Michael, Spang, Rainer, Ziepert, Marita, Horn, Heike, Staiger, Annette M., Ott, German, Schmitz, Norbert, Held, Gerhard, Einsele, Hermann, Topp, Max, Rosenwald, Andreas und Rauert-Wunderlich, Hilka (2021) Identification of a miRNA based model to detect prognostic subgroups in patients with aggressive B-cell lymphoma. Leukemia & Lymphoma 62 (5), S. 1107-1115. Volltext nicht vorhanden.

Hutchinson, James A. , Kronenberg, Katharina, Riquelme, Paloma, Wenzel, Jürgen J. , Glehr, Gunther , Schilling, Hannah-Lou , Zeman, Florian, Evert, Katja, Schmiedel, Martin, Mickler, Marion, Drexler, Konstantin, Bitterer, Florian, Cordero, Laura, Beyer, Lukas Philipp, Bach, Christian, Koestler, Josef, Burkhardt, Ralph , Schlitt, Hans J., Hellwig, Dirk, Werner, Jens M., Spang, Rainer, Schmidt, Barbara, Geissler, Edward K. und Haferkamp, Sebastian (2021) Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis. Nature Communications 12, S. 1439.

2020

Reinders, Jörg, Altenbuchinger, Michael, Limm, Katharina , Schwarzfischer, Philipp, Scheidt, Tamara, Strasser, Lisa, Richter, Julia, Szczepanowski, Monika, Huber, Christian G. , Klapper, Wolfram, Spang, Rainer und Oefner, Peter J. (2020) Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue. Scientific Reports 10 (7876), S. 1-11.

Schoen, Marian, Simeth, Jakob , Heinrich, Paul, Goertler, F., Solbrig, Stefan, Wettig, Tilo, Oefner, Peter J., Altenbuchinger, Michael und Spang, Rainer (2020) DTD: An R Package for Digital Tissue Deconvolution. J. Comput. Biol.. Volltext nicht vorhanden.

Goertler, Franziska, Schoen, Marian, Simeth, Jakob , Solbrig, Stefan, Wettig, Tilo, Oefner, Peter J., Spang, Rainer und Altenbuchinger, Michael (2020) Loss-Function Learning for Digital Tissue Deconvolution. J. Comput. Biol.. Volltext nicht vorhanden.

Minderjahn, Julia, Schmidt, Andreas, Fuchs, Andreas , Schill, Rudolf, Raithel, Johanna, Babina, Magda , Schmidl, C. , Gebhard, Claudia, Schmidhofer, Sandra, Mendes, Karina , Ratermann, Anna, Glatz, Dagmar, Nützel, Margit, Edinger, Matthias, Hoffmann, Petra, Spang, Rainer , Längst, Gernot, Imhof, A. und Rehli, Michael (2020) Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. Nat Commun 11, S. 402.

Schill, Rudolf, Solbrig, Stefan, Wettig, Tilo und Spang, Rainer (2020) Modelling cancer progression using Mutual Hazard Networks. Bioinformatics 36 (1), S. 241-249. Volltext nicht vorhanden.

2019

Arlt, A., von Bonin, F., Rehberg, Thorsten, Perez-Rubio, Paula, Engelmann, Julia C. , Limm, Katharina , Reinke, S., Dullin, C., Sun, Xueni, Specht, R., Maulhardt, M., Linke, F. , Bunt, G., Klapper, W., Vockerodt, M., Wilting, J., Pukrop, T., Dettmer, Katja, Gronwald, Wolfram, Oefner, Peter J., Spang, Rainer und Kube, D. (2019) High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination. Mol Oncol. Volltext nicht vorhanden.

Altenbuchinger, Michael, Zacharias, Helena, Solbrig, S., Schaefer, Andreas, Buyukozkan, M., Schultheiss, U. T. , Kotsis, F., Köttgen, Anna, Spang, Rainer, Oefner, Peter J., Krumsiek, J. und Gronwald, Wolfram (2019) A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study. Scientific Reports 9 (1), S. 13954.

Staiger, A. M., Altenbuchinger, Michael, Ziepert, M., Kohler, Christian, Horn, H., Huttner, Michael , Huttl, K. S., Glehr, Gunther , Klapper, W., Szczepanowski, M., Richter, J., Stein, H., Feller, A. C., Moller, P., Hansmann, M. L., Poeschel, V., Held, G., Loeffler, M., Schmitz, N., Trumper, L., Pukrop, T., Rosenwald, A., Ott, G., Spang, Rainer , Emed Demonstrator Project, und German High Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL), (2019) A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL. Leukemia. Volltext nicht vorhanden.

Wagner, M., Hansel, R., Reinke, S., Richter, J., Altenbuchinger, Michael, Braumann, U. D., Spang, Rainer, Loffler, M. und Klapper, W. (2019) Automated macrophage counting in DLBCL tissue samples: a ROF filter based approach. Biol Proced Online 21, S. 13.

Itzel, T., Spang, Rainer, Maass, T., Munker, S., Roessler, S. , Ebert, M. P., Schlitt, Hans J., Herr, Wolfgang, Evert, Matthias und Teufel, A. (2019) Random gene sets in predicting survival of patients with hepatocellular carcinoma. J. Mol. Med.. Volltext nicht vorhanden.

Kleo, K., Dimitrova, L., Oker, E., Tomaszewski, N., Berg, E., Taruttis, Franziska, Engelmann, Julia C. , Schwarzfischer, Philipp, Reinders, Jörg , Spang, Rainer, Gronwald, Wolfram , Oefner, Peter J. und Hummel, Michael (2019) Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma. BMC Cancer 19 (1), S. 322.

Zacharias, Helena, Altenbuchinger, Michael, Schultheiss, U. T., Samol, Claudia, Kotsis, F., Poguntke, I., Sekula, P. , Krumsiek, J., Köttgen, Anna, Spang, Rainer, Oefner, Peter J. und Gronwald, Wolfram (2019) A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease. Journal of Proteome Research. Volltext nicht vorhanden.

Schnitter, A., Kohler, Christian , Reddemann, K., Reinke, S., Thorns, C., Fend, F., Federmann, B., Moeller, P., Szczepanowski, Monika, Spang, Rainer und Klapper, Wolfram (2019) Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse. Journal of Hematopathology 12 (1), S. 11-17.

Ziegler, Christian, Graf, Johannes, Faderl, Stefan, Schedlbauer, Jessica, Strieder, Nicholas, Förstl, Bianca, Spang, Rainer, Bruckmann, Astrid, Merkl, Rainer , Hombach, Sonja und Kretz, Markus (2019) The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis. EMBO Rep., e46612. Volltext nicht vorhanden.

2018

Heinrich, Paul, Kohler, Christian , Ellmann, Lisa, Kuerner, Paul, Spang, Rainer, Oefner, Peter J. und Dettmer, Katja (2018) Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR. Scientific Reports 8 (17910), S. 1-10.

Fröhlich, Holger, Balling, R. , Beerenwinkel, N., Kohlbacher, O., Kumar, S., Lengauer, T., Maathuis, M. H., Moreau, Y., Murphy, S. A., Przytycka, T. M. , Rebhan, M., Rost, H. , Schuppert, A. , Schwab, M., Spang, Rainer, Stekhoven, D., Sun, J., Weber, A., Ziemek, D. und Zupan, B. (2018) From hype to reality: data science enabling personalized medicine. BMC Med 16 (1), S. 150.

Cho, H., Berger, B., Peng, J., Galitzine, C., Vitek, O., Beltran, P. M. J., Cristea, I. M., Görtler, Franziska, Solbrig, Stefan, Wettig, Tilo, Oefner, Peter J. , Spang, Rainer, Altenbuchinger, Michael, Basso, R. S., Hochbaum, D., Vandin, F., Silverbush, D., Cristea, S., Yanovich, G., Geiger, T., Beerenwinkel, N., Sharan, R., Zhou, Z., Luhmann, N., Alikhan, N. F. und Achtman, M. (2018) Principles of Systems Biology, No. 31. Cell Syst 7 (2), S. 133-135. Volltext nicht vorhanden.

Reinke, Sarah , Richter, Julia, Fend, Falko, Feller, Alfred, Hansmann, Martin-Leo, Hüttl, Katrin, Oschlies, Ilske, Ott, German, Möller, Peter, Rosenwald, Andreas, Stein, Harald, Altenbuchinger, Michael, Spang, Rainer und Klapper, Wolfram (2018) Round-robin test for the cell-of-origin classification of diffuse large B-cell lymphoma—a feasibility study using full slide staining. Virchows Archiv. Volltext nicht vorhanden.

Görtler, Franziska, Solbrig, Stefan, Wettig, Tilo, Oefner, Peter J. , Spang, Rainer und Altenbuchinger, Michael (2018) Loss-function learning for digital tissue deconvolution. In: Raphael, Benjamin J., (ed.) Research in Computational Molecular Biology : 22nd Annual International Conference, RECOMB 2018, Paris, France, April 21-24, 2018, Proceedings. Lecture Notes in Computer Science, 10812. Springer International Publishing, Cham, S. 75-89. ISBN 978-3-319-89929-9 ; 978-3-319-89928-2. Volltext nicht vorhanden.

Feist, M., Schwarzfischer, Philipp, Heinrich, Paul, Sun, Xueni, Kemper, J., von Bonin, F., Perez-Rubio, Paula, Taruttis, Franziska, Rehberg, Thorsten, Dettmer, Katja, Gronwald, Wolfram, Reinders, Jörg, Engelmann, Julia C. , Dudek, J., Klapper, W., Trumper, L., Spang, Rainer, Oefner, Peter J. und Kube, D. (2018) Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression. Nat Commun 9 (1), S. 1514.

Horn, H., Kohler, Christian, Witzig, R., Kreuz, M. , Leich, E., Klapper, W., Hummel, M., Loeffler, M., Trumper, L., Spang, Rainer, Rosenwald, A. und Ott, G. (2018) Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2. Haematologica. Volltext nicht vorhanden.

Schill, Rudolf, Solbrig, Stefan, Wettig, Tilo und Spang, Rainer (2018) Modelling cancer progression using Mutual Hazard Networks. biorxiv.org. (Eingereicht)

Riquelme, Paloma , Haarer, Jan, Kammler, Anja, Walter, Lisa , Tomiuk, Stefan, Ahrens, Norbert , Wege, Anja K. , Goecze, Ivan, Zecher, Daniel, Banas, Bernhard , Spang, Rainer , Fändrich, Fred, Lutz, Manfred B., Sawitzki, Birgit, Schlitt, Hans J. , Ochando, Jordi , Geissler, Edward K. und Hutchinson, James A. (2018) TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity. Nature Communications 9 (2858), S. 1-18.

2017

Paul, U., Richter, J., Stuhlmann-Laiesz, C., Kreuz, M. , Nagel, I., Horn, H., Staiger, A. M., Aukema, S. M., Hummel, M., Ott, G., Spang, Rainer, Rosenwald, A., Feller, A. C., Cogliatti, S., Stein, H., Hansmann, M. L., Moller, P., Szczepanowski, M., Burkhardt, B., Pfreundschuh, M., Schmitz, N., Loeffler, M., Trumper, L., Siebert, R. und Klapper, W. (2017) Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC. Leuk. Lymphoma, S. 1-9. Volltext nicht vorhanden.

Zacharias, Helena, Rehberg, Thorsten, Mehrl, S., Richtmann, D., Wettig, Tilo, Oefner, Peter J., Spang, Rainer, Gronwald, Wolfram und Altenbuchinger, Michael (2017) Scale-Invariant Biomarker Discovery in Urine and Plasma Metabolite Fingerprints. J. Proteome Res.. Volltext nicht vorhanden.

Altenbuchinger, Michael, Schwarzfischer, Philipp, Rehberg, Thorsten, Reinders, Jörg , Kohler, Christian , Gronwald, Wolfram , Richter, J., Szczepanowski, M., Masqué-Soler, N., Klapper, W., Oefner, Peter J. und Spang, Rainer (2017) Molecular signatures that can be transferred across different omics platforms. Bioinformatics 33 (14), i333-i340. Volltext nicht vorhanden.

Oschlies, I., Kohler, Christian, Szczepanowski, Monika, Koch, K., Gontarewicz, A., Metze, D., Hillen, U., Richter, J., Spang, Rainer und Klapper, W. (2017) Spindle-cell variant of primary cutaneous follicle center B-cell lymphomas are germinal center B-cell lymphomas by gene expression profiling using formalin-fixed paraffin embedded specimen. J Invest Dermatol. Volltext nicht vorhanden.

Szczepanowski, M., Lange, J., Kohler, Christian, Masque-Soler, N., Zimmermann, M., Aukema, S. M., Altenbuchinger, Michael, Rehberg, Thorsten, Mahn, F., Siebert, R., Spang, Rainer, Burkhardt, B. und Klapper, W. (2017) Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents. Br. J. Haematol.. Volltext nicht vorhanden.

Rohde, M., Bonn, B. R., Zimmermann, M., Lange, J., Moricke, A., Klapper, W., Oschlies, I., Szczepanowski, M., Nagel, I., Schrappe, M., Loeffler, M., Siebert, R., Reiter, A., Burkhardt, B., Altenbuchinger, Michael, Dettmer-Wilde, Katja, Engelmann, Julia C. , Gronwald, Wolfram , Oefner, Peter J. , Schwarzfischer, Philipp, Taruttis, Franziska und Spang, Rainer (2017) Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols. Haematologica 102 (6), S. 1091-1098. Volltext nicht vorhanden.

Feist, M., Kemper, J., Taruttis, Franziska, Rehberg, Thorsten, Engelmann, Julia C. , Gronwald, Wolfram, Hummel, Michael, Spang, Rainer und Kube, Dieter (2017) Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis. International Journal of Cancer: Int. J. Cancer. Volltext nicht vorhanden.

Schwarzfischer, Philipp, Reinders, Jörg, Dettmer, Katja , Kleo, K., Dimitrova, L., Hummel, M., Feist, M., Kube, D., Szczepanowski, M., Klapper, W., Taruttis, Franziska, Engelmann, Julia C. , Spang, Rainer, Gronwald, Wolfram und Oefner, Peter J. (2017) Comprehensive metaboproteomics of Burkitt's and diffuse large B-cell lymphoma cell lines and primary tumor tissues reveals distinct differences in pyruvate content and metabolism. Journal of Proteome Research 16, S. 1105-1120. Volltext nicht vorhanden.

Taruttis, Franziska, Feist, M., Schwarzfischer, Philipp, Gronwald, Wolfram, Kube, D., Spang, Rainer und Engelmann, Julia C. (2017) External calibration with Drosophila whole-cell spike-ins delivers absolute mRNA fold changes from human RNA-Seq and qPCR data. BioTechniques 62 (2), S. 53-61. Volltext nicht vorhanden.

Lottaz, Claudio, Gronwald, Wolfram , Spang, Rainer und Engelmann, Julia C. (2017) High-Dimensional Profiling for Computational Diagnosis. In: Bioinformatics : Volume II: Structure, Function, and Applications. Methods in Molecular Biology, 1526. Springer, New York, S. 205-229. ISBN 978-1-4939-6611-0. Volltext nicht vorhanden.

2016

Hosseini, H., Obradovic, M. M., Hoffmann, M., Harper, K. L., Sosa, M. S., Werner-Klein, M., Nanduri, L. K. , Werno, C., Ehrl, C., Maneck, M., Patwary, N., Haunschild, G., Guzvic, M., Reimelt, C., Grauvogl, Michael, Eichner, N., Weber, F., Hartkopf, A. D., Taran, F. A., Brucker, S. Y., Fehm, T., Rack, B., Buchholz, S., Spang, Rainer, Meister, Gunter, Aguirre-Ghiso, J. A. und Klein, Christoph A. (2016) Early dissemination seeds metastasis in breast cancer. Nature 540, S. 552-558. Volltext nicht vorhanden.

Altenbuchinger, Michael, Rehberg, Thorsten, Zacharias, Helena, Stämmler, Frank, Dettmer, Katja , Weber, Daniela, Hiergeist, Andreas, Gessner, Andre, Holler, Ernst, Oefner, Peter J. und Spang, Rainer (2016) Reference point insensitive molecular data analysis. Bioinformatics.

Stämmler, Frank, Glasner, J., Hiergeist, Andreas, Holler, Ernst, Weber, Daniela, Oefner, Peter J. , Gessner, Andre und Spang, Rainer (2016) Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. Microbiome 4 (1), S. 28.

Moffa, Giusi, Erdmann, Gerrit, Voloshanenko, Oksana, Hundsrucker, Christian, Sadeh, Mohammad Javad, Boutros, Michael und Spang, Rainer (2016) Refining Pathways: A Model Comparison Approach. PLoS One 11 (6), e0155999.

Teufel, Andreas, Itzel, Timo, Erhart, W., Brosch, M. , Wang, X. Y., Kim, Y. O., von Schoenfels, Witigo, Herrmann, A., Bruckner, S., Stickel, F., Dufour, J. F. , Chavakis, T., Hellerbrand, Claus, Spang, Rainer, Maass, Thorsten, Becker, T., Schreiber, S., Schafmayer, C., Schuppan, D. und Hampe, J. (2016) Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues from Patients. Gastroenterology. Volltext nicht vorhanden.

Schrader, A., Meyer, Katharina, Walther, N., Stolz, A., Feist, M., Hand, E., Bonin, F. von, Evers, Maurits, Kohler, Christian, Shirneshan, K., Vockerodt, M., Klapper, W., Szczepanowski, M., Murray, P. G., Bastians, H., Trümper, Lorenz, Spang, Rainer und Kube, Dieter (2016) Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data. OncoTarget.

Moeckel, Sylvia, Vollmann-Zwerenz, Arabel, Proescholdt, Martin A., Brawanski, Alexander, Riemenschneider, Markus J., Bogdahn, Ulrich, Bosserhoff, A. K. , Spang, Rainer und Hau, Peter (2016) Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro. PLoS ONE 11 (3), e0151312.

2015

Pirkl, Martin, Hand, E., Kube, D. und Spang, Rainer (2015) Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models. Bioinformatics.

Hochrein, Jochen, Zacharias, Helena, Taruttis, Franziska, Samol, Claudia, Engelmann, Julia C., Spang, Rainer, Oefner, Peter J. und Gronwald, Wolfram (2015) Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation. J. Proteome Res. 14 (8), S. 3217-3228. Volltext nicht vorhanden.

Taruttis, Franziska, Spang, Rainer und Engelmann, Julia C. (2015) A statistical approach to virtual cellular experiments: improved causal discovery using accumulation IDA (aIDA). Bioinformatics 31, S. 22.

Masqué-Soler, Neus, Szczepanowski, Monika, Kohler, Christian W., Aukema, Sietse M., Nagel, Inga, Richter, Julia, Siebert, Reiner, Spang, Rainer, Burkhardt, Birgit und Klapper, Wolfram (2015) Clinical and pathological features of Burkitt lymphoma showing expression of BCL2 - an analysis including gene expression in formalin-fixed paraffin-embedded tissue. British Journal of Haematology = Br J Haematol 171, S. 501-508.

Engelmann, Julia C., Amann, Thomas, Ott-Rötzer, Brigitta, Nützel, Margit, Reinders, Yvonne, Reinders, Jörg, Thasler, Wolfgang E., Kristl, Theresa, Teufel, Andreas, Huber, Christian G., Oefner, Peter J., Spang, Rainer und Hellerbrand, Claus (2015) Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma. PLoS Computational Biology 11 (5), S. 1-22.

Weber, Daniela, Oefner, Peter J., Hiergeist, Andreas, Koestler, Josef, Gessner, Andre, Weber, Markus, Hahn, Joachim, Wolff, Daniel, Stämmler, Frank, Spang, Rainer, Herr, Wolfgang, Dettmer, Katja und Holler, Ernst (2015) Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome. Blood 126 (14), S. 1723-1728.

2014

Hau, Peter, Moeckel, Sylvia, Meyer, Katharina, Leukel, Petra, Heudorfer, Fabian, Seliger, Corinna, Stangl, Christina, Bogdahn, Ulrich, Proescholdt, Martin A., Brawanski, Alexander, Vollmann-Zwerenz, Arabel, Riemenschneider, Markus J., Bosserhoff, Anja-Katrin und Spang, Rainer (2014) Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro. PLoS ONE 9 (9), e108632.

Hannus, Michael, Beitzinger, Michaela, Engelmann, Julia C., Weickert, Marie-Theresa, Spang, Rainer, Hannus, Stefan und Meister, Gunter (2014) siPools: highly complex but accurately defined siRNA pools eliminate off-target effects. Nucleic Acids Research 42, S. 8049-8061.

Holler, Ernst, Butzhammer, Peter, Schmid, Karin, Hundsrucker, Christian, Koestler, Josef, Peter, Katrin, Zhu, Wentao, Sporrer, Daniela, Hehlgans, Thomas, Kreutz, Marina, Holler, Barbara, Wolff, Daniel, Edinger, Matthias, Andreesen, Reinhard, Levine, John E., Ferrara, James L., Gessner, Andre, Spang, Rainer und Oefner, Peter J. (2014) Metagenomic analysis of the stool microbiome in patients receiving allogeneic SCT: Loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal GvHD. Biology of Blood and Marrow Transplantation 20 (5), S. 640-645. Volltext nicht vorhanden.

Dorn, Christoph, Engelmann, Julia C., Saugspier, Michael Sebastian, Koch, Andreas, Hartmann, Arndt, Spang, Rainer, Bosserhoff, Anja Katrin und Hellerbrand, Claus (2014) Increased expression of c-Jun in nonalcoholic fatty liver disease. Laboratory Investigation 94, S. 394-408. Volltext nicht vorhanden.

Dümcke, Sebastian, Bräuer, Johannes, Anchang, Benedict Nchang, Spang, Rainer, Beerenwinkel, Niko und Tresch, Achim (2014) Exact likelihood computation in Boolean networks with probabilistic time delays, and its application in signal network reconstruction. Bioinformatics 30 (3), S. 414-419.

Salaverria, Itziar, Martin-Guerrero, Idoia, Wagener, Rabea, Kreuz, Markus, Kohler, Christian, Richter, Julia, Pienkowska-Grela, Barbara, Adam, Patrick, Burkhardt, Birgit, Claviez, Alexander, Damm-Welk, Christine, Drexler, H. G., Hummel, Michael, Jaffe, Elaine S., Kueppers, Ralf, Lefebvre, Christine, Lisfeld, Jasmin, Loeffler, Markus, Mcleod, Roderick A., Nagel, Inga, Oschlies, Ilske, Rosolowski, Maciej, Russell, Robert B., Rymkiewicz, Grzegorz, Schindler, Detlev, Schlesner, Matthias, Scholtysik, Rene, Schwaenen, Carsten, Spang, Rainer, Szczepanowski, Monika, Truemper, Lorenz, Vater, Inga, Wessendorf, Swen, Klapper, Wolfram und Siebert, Rainer (2014) A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma. Blood 123, S. 1187-1198. Volltext nicht vorhanden.

Dorn, Christoph , Engelmann, Julia C., Saugspier, Michael, Koch, Andreas, Hartmann, Arndt, Müller, Martina, Spang, Rainer, Bosserhoff, Anja und Hellerbrand, Claus (2014) Increased expression of c-Jun in nonalcoholic fatty liver disease. Laboratory Investigation 94 (4), S. 394-408. Volltext nicht vorhanden.

2013

Schmid, Rainer, Meyer, Katharina, Spang, Rainer, Schittek, Birgit und Bosserhoff, Anja-Katrin (2013) YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis. PLoS ONE 8 (12).

Sadeh, Mohammad Javad, Moffa, Giusi und Spang, Rainer (2013) Considering unknown unknowns: reconstruction of nonconfoundable causal relations in biological networks. Journal of computational biology 20 (11), S. 920-932. Volltext nicht vorhanden.

Burghardt, Tillmann, Kastner, Jürgen, Suleiman, Hani, Rivera-Milla, Eric, Stepanova, Natalya, Lottaz, Claudio, Kubitza, Marion, Böger, Carsten A., Schmidt, Sarah, Gorski, Mathias, de Vries, Uwe, Schmidt, Helga, Hertting, Irmgard, Kopp, Jeffrey, Rascle, Anne, Moser, Markus, Heid, Iris M., Warth, Richard, Spang, Rainer, Wegener, Joachim, Mierke, Claudia T., Englert, Christoph und Witzgall, Ralph (2013) LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys. Journal of the American Society of Nephrology : JASN 24 (11), S. 1830-1848. Volltext nicht vorhanden.

Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D., Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R., Glimm, Hanno, Spang, Rainer und Boutros, Michael (2013) Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nature communications 4, S. 2610.

Masqué-Soler, Neus, Szczepanowski, Monika, Kohler, Christian, Spang, Rainer und Klapper, Wolfram (2013) Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens. Blood 122 (11), S. 1985-1986.

Schmid, Rainer, Meyer, Katharina, Spang, Rainer, Schittek, Birgit und Bosserhoff, Anja-Katrin (2013) Melanoma inhibitory activity promotes melanoma development through activation of YBX1. Pigment cell & melanoma research 26 (5), S. 685-696. Volltext nicht vorhanden.

Walther, Neele, Ulrich, Antje, Vockerodt, Martina, von Bonin, Frederike, Klapper, Wolfram, Meyer, Katharina, Eberth, Sonja, Pukrop, Tobias, Spang, Rainer, Trümper, Lorenz und Kube, Dieter (2013) Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma. The American journal of pathology 182 (4), S. 1092-1098. Volltext nicht vorhanden.

Kelly, Gemma L, Stylianou, Julianna, Rasaiyaah, Jane, Wei, Wenbin, Thomas, Wendy, Croom-Carter, Deborah, Kohler, Christian, Spang, Rainer, Woodman, Ciaran, Kellam, Paul, Rickinson, Alan N. und Bell, Andrew I. (2013) Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature. Journal of virology 87 (5), S. 2882-2894.

Aukema, Sietse M., Kreuz, Markus, Kohler, Christian, Rosolowski, Maciej, Hasenclever, Dirk, Hummel, Michael, Küppers, Ralf, Lenze, Dido, Ott, German, Pott, Christiane, Richter, Julia, Rosenwald, Andreas, Szczepanowski, Monika, Schwaenen, Carsten, Stein, Harald, Trautmann, Heiko, Wessendorf, Swen, Trümper, Lorenz, Loeffler, Markus, Spang, Rainer, Kluin, Philip M., Klapper, Wolfram und Siebert, Reiner (2013) Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma. Haematologica 99 (4), S. 726-735.

Schif, Birgit, Lennerz, Jochen K., Kohler, Christian, Bentink, Stefan, Kreuz, Markus, Melzner, Ingo, Ritz, Olga, Trümper, Lorenz, Loeffler, Markus, Spang, Rainer und Möller, Peter (2013) SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients. Oncotarget 4 (1), S. 35-47.

2012

Hochrein, Jochen, Klein, Matthias S., Zacharias, Helena, Li, Juan, Wijffels, Gene, Schirra, Horst Joachim, Spang, Rainer, Oefner, Peter J. und Gronwald, Wolfram (2012) Performance evaluation of algorithms for the classification of metabolic 1H NMR fingerprints. Journal of proteome research 11 (12), S. 6242-6251. Volltext nicht vorhanden.

Richter, Julia, Schlesner, Matthias, Hoffmann, Steve, Kreuz, Markus, Leich, Ellen, Burkhardt, Birgit, Rosolowski, Maciej, Ammerpohl, Ole, Wagener, Rabea, Bernhart, Stephan H., Lenze, Dido, Szczepanowski, Monika, Paulsen, Maren, Lipinski, Simone, Russell, Robert B., Adam-Klages, Sabine, Apic, Gordana, Claviez, Alexander, Hasenclever, Dirk, Hovestadt, Volker, Hornig, Nadine, Korbel, Jan O., Kube, Dieter, Langenberger, David, Lawerenz, Chris, Lisfeld, Jasmin, Meyer, Katharina, Picelli, Simone, Pischimarov, Jordan, Radlwimmer, Bernhard, Rausch, Tobias, Rohde, Marius, Schilhabel, Markus, Scholtysik, René, Spang, Rainer, Trautmann, Heiko, Zenz, Thorsten, Borkhardt, Arndt, Drexler, Hans G., Möller, Peter, MacLeod, Roderick A. F., Pott, Christiane, Schreiber, Stefan, Trümper, Lorenz, Loeffler, Markus, Stadler, Peter F., Lichter, Peter, Eils, Roland, Küppers, Ralf, Hummel, Michael, Klapper, Wolfram, Rosenstiel, Philip, Rosenwald, Andreas, Brors, Benedikt und Siebert, Reiner (2012) Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nature genetics 44 (12), S. 1316-1320. Volltext nicht vorhanden.

Beier, Christoph P., Kumar, Praveen, Meyer, Katharina, Leukel, Petra, Bruttel, Valentin, Aschenbrenner, Ines, Riemenschneider, Markus J., Fragoulis, Athanassios, Rümmele, Petra, Lamszus, Katrin, Schulz, Jörg B., Weis, Joachim, Bogdahn, Ulrich, Wischhusen, Jörg, Hau, Peter, Spang, Rainer und Beier, Dagmar (2012) The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem Cells and Development 21 (15), S. 2753-2761. Volltext nicht vorhanden.

Schrader, Alexandra, Bentink, Stefan, Spang, Rainer, Lenze, Dido, Hummel, Michael, Kuo, Michael, Arrand, John R., Murray, Paul G., Trümper, Lorenz, Kube, Dieter und Vockerodt, Martina (2012) High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas. International journal of cancer 131 (4), E348-E361. Volltext nicht vorhanden.

Odoardi, Francesca, Sie, Christopher, Streyl, Kristina, Ulaganathan, Vijay K., Schläger, Christian, Lodygin, Dmitri, Heckelsmiller, Klaus, Nietfeld, Wilfried, Ellwart, Joachim, Klinkert, Wolfgang E. F., Lottaz, Claudio, Nosov, Mikhail, Brinkmann, Volker, Spang, Rainer, Lehrach, Hans, Vingron, Martin, Wekerle, Hartmut, Flügel-Koch, Cassandra und Flügel, Alexander (2012) T cells become licensed in the lung to enter the central nervous system. Nature 488 (7413), S. 675-679. Volltext nicht vorhanden.

Hertwig, Falk, Meyer, Katharina, Braun, Sebastian, Ek, Sara, Spang, Rainer, Pfenninger, Cosima V., Artner, Isabella, Prost, Gaëlle, Chen, Xinbin, Biegel, Jaclyn A., Judkins, Alexander R., Englund, Elisabet und Nuber, Ulrike A. (2012) Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer research 72 (13), S. 3381-3392. Volltext nicht vorhanden.

Kohl, Stefanie M., Klein, Matthias S., Hochrein, Jochen, Oefner, Peter J., Spang, Rainer und Gronwald, Wolfram (2012) State-of-the art data normalization methods improve NMR-based metabolomic analysis. Metabolomics 8 (Suppl), S. 146-160. Volltext nicht vorhanden.

Klapper, Wolfram, Kreuz, Markus, Kohler, Christian, Burkhardt, Birgit, Szczepanowski, Monika, Salaverria, Itziar, Hummel, Michael, Loeffler, Markus, Pellissery, Shoji, Woessmann, Wilhelm, Schwänen, Carsten, Trümper, Lorenz, Wessendorf, Swen, Spang, Rainer, Hasenclever, Dirk und Siebert, Reiner (2012) Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. Blood 119 (8), S. 1882-1887. Volltext nicht vorhanden.

Engelmann, Julia C. und Spang, Rainer (2012) A least angle regression model for the prediction of canonical and non-canonical miRNA-mRNA interactions. PloS ONE 7 (7), e40634.

2011

Appel, Inka, Gronwald, Wolfram und Spang, Rainer (2011) Estimating classification probabilities in high-dimensional diagnostic studies. Bioinformatics 27 (18), S. 2563-2570. Volltext nicht vorhanden.

Maneck, Matthias, Schrader, Alexandra, Kube, Dieter und Spang, Rainer (2011) Genomic data integration using guided clustering. Bioinformatics 27 (16), S. 2231-2238. Volltext nicht vorhanden.

Salaverria, Itziar, Philipp, Claudia, Oschlies, Ilske, Kohler, Christian, Kreuz, Markus, Szczepanowski, Monika, Burkhardt, Birgit, Trautmann, Heiko, Gesk, Stefan, Andrusiewicz, Miroslaw, Berger, Hilmar, Fey, Miriam, Harder, Lana, Hasenclever, Dirk, Hummel, Michael, Loeffler, Markus, Mahn, Friederike, Martin-Guerrero, Idoia, Pellissery, Shoji, Pott, Christiane, Pfreundschuh, Michael, Reiter, Alfred, Richter, Julia, Rosolowski, Maciej, Schwaenen, Carsten, Stein, Harald, Trümper, Lorenz, Wessendorf, Swen, Spang, Rainer, Küppers, Ralf, Klapper, Wolfram und Siebert, Reiner (2011) Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults. Blood 118 (1), S. 139-147. Volltext nicht vorhanden.

VerMilyea, Matthew, Maneck, Matthias, Yoshida, Naoko, Blochberger, Isabell, Suzuki, Emi, Suzuki, Toru, Spang, Rainer, Klein, Christoph A. und Perry, Anthony C. F. (2011) Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. The EMBO journal 30 (9), S. 1841-1851. Volltext nicht vorhanden.

Seitz, Volkhard, Butzhammer, Peter, Hirsch, Burkhard, Hecht, Jochen, Gütgemann, Ines, Ehlers, Anke, Lenze, Dido, Oker, Elisabeth, Sommerfeld, Anke, von der Wall, Edda, König, Christoph, Zinser, Christian, Spang, Rainer und Hummel, Michael (2011) Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One 6 (11), e26837.

2010

Scholtysik, René, Kreuz, Markus, Klapper, Wolfram, Burkhardt, Birgit, Feller, Alfred, Hummel, Michael, Loeffler, Markus, Rosolowski, Maciej, Schwaenen, Carsten, Spang, Rainer, Stein, Harald, Thorns, Christoph, Trümper, Lorenz, Vater, Inga, Wessendorf, Swen, Zenz, Thorsten, Siebert, Reiner und Küppers, Ralf (2010) Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis. Haematologica 95 (12), S. 2047-2055.

Lottaz, Claudio, Beier, Dagmar, Meyer, Katharina, Kumar, Praveen, Hermann, Andreas, Schwarz, Johannes, Junker, Markus, Oefner, Peter J., Bogdahn, Ulrich, Wischhusen, J., Spang, Rainer, Storch, Alexander und Beier, Christoph P. (2010) Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of origin. Cancer research 70 (5), S. 2030-2040. Volltext nicht vorhanden.

2009

Thieme, Marian, Lottaz, Claudio, Niederstätter, Harald, Parson, Walther, Spang, Rainer und Oefner, Peter J. (2009) ReseqChip: automated integration of multiple local context probe data from the MitoChip array in mitochondrial DNA sequence assembly. BMC bioinformatics 10, S. 440.

Almstetter, Martin F., Appel, Inka, Gruber, Michael, Lottaz, Claudio, Timischl, Birgit, Spang, Rainer, Dettmer, Katja und Oefner, Peter J. (2009) Integrative normalization and comparative analysis for metabolic fingerprinting by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Analytical chemistry 81 (14), S. 5731-5739. Volltext nicht vorhanden.

Vlad, Marcel O., Corlan, Alexandru D., Morán, Federico, Spang, Rainer, Oefner, Peter J. und Ross, John (2009) Kinetic laws, phase-phase expansions, renormalization group, and INR calibration. Proceedings of the National Academy of Sciences of the United States of America 106 (16), S. 6465-6470. Volltext nicht vorhanden.

Anchang, Benedict Nchang, Sadeh, Mohammad Javad, Jacob, Juby, Tresch, Achim, Vlad, Marcel O., Oefner, Peter J. und Spang, Rainer (2009) Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models. Proceedings of the National Academy of Sciences of the United States of America 106 (16), S. 6447-6452. Volltext nicht vorhanden.

Martín-Subero, José I., Kreuz, Markus, Bibikova, Marina, Bentink, Stefan, Ammerpohl, Ole, Wickham-Garcia, Eliza, Rosolowski, Maciej, Richter, Julia, Lopez-Serra, Lidia, Ballestar, Esteban, Berger, Hilmar, Agirre, Xabier, Bernd, Heinz-Wolfram, Calvanese, Vincenzo, Cogliatti, Sergio B., Drexler, Hans G., Fan, Jian-Bing, Fraga, Mario F., Hansmann, Martin L., Hummel, Michael, Klapper, Wolfram, Korn, Bernhard, Küppers, Ralf, Macleod, Roderick A. F., Möller, Peter, Ott, German, Pott, Christiane, Prosper, Felipe, Rosenwald, Andreas, Schwaenen, Carsten, Schübeler, Dirk, Seifert, Marc, Stürzenhofecker, Benjamin, Weber, Michael, Wessendorf, Swen, Loeffler, Markus, Trümper, Lorenz, Stein, Harald, Spang, Rainer, Esteller, Manel, Barker, David, Hasenclever, Dirk und Siebert, Reiner (2009) New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood 113 (11), S. 2488-2497. Volltext nicht vorhanden.

Schwaenen, Carsten, Viardot, Andreas, Berger, Hilmar, Barth, Thomas F. E., Bentink, Stefan, Döhner, Hartmut, Enz, Martina, Feller, Alfred C., Hansmann, Martin-Leo, Hummel, Michael, Kestler, Hans A., Klapper, Wolfram, Kreuz, Markus, Lenze, Dido, Loeffler, Markus, Möller, Peter, Müller-Hermelink, Hans-Konrad, Ott, German, Rosolowski, Maciej, Rosenwald, Andreas, Ruf, Sandra, Siebert, Reiner, Spang, Rainer, Stein, Harald, Truemper, Lorenz, Lichter, Peter, Bentz, Martin und Wessendorf, Swen (2009) Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes, Chromosomes and Cancer 48 (1), S. 39-54. Volltext nicht vorhanden.

2008

Fröhlich, H., Beissbarth, T., Tresch, A., Kostka, D., Jacob, Juby, Spang, Rainer und Markowetz, F. (2008) Analyzing gene perturbation screens with nested effects models in R and bioconductor. Bioinformatics 24 (21), S. 2549-2550. Volltext nicht vorhanden.

Bentink, Stefan, Wessendorf, S., Schwaenen, C., Rosolowski, M., Klapper, W., Rosenwald, A., Ott, G., Banham, A. H., Berger, H., Feller, A. C., Hansmann, M. L., Hasenclever, D., Hummel, M., Lenze, D., Möller, P., Stuerzenhofecker, B., Loeffler, M., Truemper, L., Stein, H., Siebert, R. und Spang, Rainer (2008) Pathway activation patterns in diffuse large B-cell lymphomas. Leukemia 22 (9), S. 1746-1754. Volltext nicht vorhanden.

Klapper, W., Szczepanowski, M., Burkhardt, B., Berger, H., Rosolowski, M., Bentink, Stefan, Schwaenen, C., Wessendorf, S., Spang, Rainer, Moller, P., Hansmann, M. L., Bernd, H. W., Ott, G., Hummel, M., Stein, H., Loeffler, M., Trumper, L., Zimmermann, M., Reiter, A. und Siebert, R. (2008) Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials. Blood 112 (4), S. 1374-1381. Volltext nicht vorhanden.

Dierlamm, J., Murga Penas, E. M., Bentink, Stefan, Wessendorf, S., Berger, H., Hummel, M., Klapper, W., Lenze, D., Rosenwald, A., Haralambieva, E., Ott, G., Cogliatti, S. B., Möller, Peter, Schwaenen, C., Stein, H., Löffler, M., Spang, Rainer, Trumper, L. und Siebert, Reiner (2008) Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma. Haematologica 93 (5), S. 688-696.

Jacob, Juby, Jentsch, M., Kostka, Dennis, Bentink, Stefan und Spang, Rainer (2008) Detecting hierarchical structure in molecular characteristics of disease using transitive approximations of directed graphs. Bioinformatics 24 (7), S. 995-1001. Volltext nicht vorhanden.

Lottaz, Claudio, Kostka, Dennis und Spang, Rainer (2008) 26. Classification of Patients. In: Lengauer, Thomas, (ed.) Bioinformatics-From Genomes to Therapies. Wiley-VCH, Weinheim, S. 957-991. ISBN 9783527619368 (online). Volltext nicht vorhanden.

Hirsch, Burkhard, Hummel, M., Bentink, Stefan, Fouladi, F., Spang, Rainer, Zollinger, R., Stein, H. und Durkop, H. (2008) CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. The American Journal of Pathology 172 (2), S. 510-520. Volltext nicht vorhanden.

Montesinos-Rongen, M., Brunn, A., Bentink, Stefan, Basso, K., Lim, W. K., Klapper, Wolfram, Schaller, C., Reifenberger, G., Rubenstein, J., Wiestler, O. D., Spang, Rainer, Dalla-Favera, R., Siebert, Reiner und Deckert, M. (2008) Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. Leukemia 22 (2), S. 400-405. Volltext nicht vorhanden.

Kostka, Dennis und Spang, Rainer (2008) Microarray Based Diagnosis Profits from Better Documentation of Gene Expression Signatures. PLoS Computational Biology 4 (2), e22.

Lottaz, Claudio, Kostka, Dennis, Markowetz, Florian und Spang, Rainer (2008) 15. Computational diagnostics with gene expression profiles. In: Bioinformatics. Methods in Molecular Biology, 453 (15). Humana Press, Totowa, NJ, S. 281-296. ISBN 978-1-60327-428-9. Volltext nicht vorhanden.

2007

Roesch, Alexander, Becker, Bernd, Bentink, Stefan, Spang, Rainer, Vogl, Annegret, Hagen, Ilja, Landthaler, Michael und Vogt, Thomas (2007) Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Prevention 16 (11), S. 2486-2490. Volltext nicht vorhanden.

Lottaz, Claudio, Toedling, Joern und Spang, Rainer (2007) Annotation-based distance measures for patient subgroup discovery in clinical microarray studies. Bioinformatics 23 (17), S. 2256-2264. Volltext nicht vorhanden.

Markowetz, Florian und Spang, Rainer (2007) Inferring cellular networks - a review. BMC bioinformatics 8 Suppl 6, S5.

Markowetz, F., Kostka, D., Troyanskaya, O. G. und Spang, Rainer (2007) Nested effects models for high-dimensional phenotyping screens. Bioinformatics 23 (13), i305-i312.

Scheid, Stefanie und Spang, Rainer (2007) Compensating for unknown confounders in microarray data analysis using filtered permutations. Journal of computational biology 14 (5), S. 669-681. Volltext nicht vorhanden.

Scheid, Stefanie und Spang, Rainer (2007) Compensating for unknown confounders in microarray data analysis using filtered permutations. Journal of Computational Biology 14 (5), S. 669-681. Volltext nicht vorhanden.

Rhein, P., Scheid, S., Ratei, R., Hagemeier, C., Seeger, K., Kirschner-Schwabe, R., Moericke, A., Schrappe, M., Spang, Rainer, Ludwig, W.-D. und Karawajew, L. (2007) Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia. Leukemia 21 (5), S. 897-905. Volltext nicht vorhanden.

Jaeger, Jochen, Koczan, Dirk, Thiesen, Hans-Juergen, Ibrahim, Saleh M., Gross, Gerd, Spang, Rainer und Kunz, Manfred (2007) Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues. Clinical cancer research 13 (3), S. 806-815. Volltext nicht vorhanden.

2006

Jaeger, J. und Spang, Rainer (2006) Selecting normalization genes for small diagnostic microarrays. BMC Bioinformatics 7, S. 388.

Kirschner-Schwabe, R., Lottaz, Claudio, Todling, J., Rhein, P., Karawajew, L., Eckert, C., von Stackelberg, A., Ungethum, U., Kostka, Dennis, Kulozik, A. E., Ludwig, W. D., Henze, G., Spang, Rainer, Hagemeier, C. und Seeger, K. (2006) Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia. Clinical Cancer Research 12 (15), S. 4553-4561. Volltext nicht vorhanden.

Lottaz, Claudio, Yang, Xinan, Scheid, Stefanie und Spang, Rainer (2006) OrderedList - a bioconductor package for detecting similarity in ordered gene lists. Bioinformatics 22 (18), S. 2315-2316. Volltext nicht vorhanden.

Hummel, M., Bentink, S., Berger, H., Klapper, W., Wessendorf, S., Barth, T. F., Bernd, H. W., Cogliatti, S. B., Dierlamm, J., Feller, A. C. und Spang, Rainer (2006) A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. New England Journal of Medicine 354 (23), S. 2419-2430. Volltext nicht vorhanden.

Toedling, J., Rhein, P., Ratei, R., Karawajew, L. und Spang, Rainer (2006) Automated in-silico detection of cell populations in flow cytometry readouts and its application to leukemia disease monitoring. BMC Bioinformatics 7, S. 282.

Yang, X., Bentink, S., Scheid, S. und Spang, Rainer (2006) Similarities of ordered gene lists. Journal of Bioinformatics and Computational BiologyJ Bioinform Comput Biol 4 (3), S. 693-708. Volltext nicht vorhanden.

2005

Markowetz, F., Bloch, J. und Spang, Rainer (2005) Non-transcriptional pathway features reconstructed from secondary effects of RNA interference. Bioinformatics 21 (21), S. 4026-4032. Volltext nicht vorhanden.

Yang, X., Bentink, Stefan und Spang, Rainer (2005) Detecting common gene expression patterns in multiple cancer outcome entities. Biomedical Microdevices 7 (3), S. 247-251. Volltext nicht vorhanden.

Lottaz, Claudio und Spang, Rainer (2005) stam – a Bioconductor compliant R package for structured analysis of microarray data. BMC Bioinformatics 6, S. 211.

Scheid, S. und Spang, Rainer (2005) twilight; a Bioconductor package for estimating the local false discovery rate. Bioinformatics 21 (12), S. 2921-2922. Volltext nicht vorhanden.

Jaeger, J., Weichenhan, D., Ivandic, B. und Spang, Rainer (2005) Early diagnostic marker panel determination for microarray based clinical studies. Statistical Applications in Genetics and Molecular Biology 4 (1), article 9. Volltext nicht vorhanden.

Lottaz, Claudio und Spang, Rainer (2005) Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data. Bioinformatics 21 (9), S. 1971-1978.

Lottaz, Claudio, Kostka, Dennis, Markowetz, Florian und Spang, Rainer (2005) Traces of molecular disease mechanisms on microarrays. Methods in Molecular Biology 453, S. 281-296. Volltext nicht vorhanden.

2004

Kostka, Dennis und Spang, Rainer (2004) Finding disease specific alterations in the co-expression of genes. Bioinformatics 20 Suppl 1, i194-i199. Volltext nicht vorhanden.

Scheid, Stefanie und Spang, Rainer (2004) A stochastic downhill search algorithm for estimating the local false discovery rate. IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB 1 (3), S. 98-108. Volltext nicht vorhanden.

2003

Blaxall, B. C., Spang, Rainer, Rockman, H. A. und Koch, W. J. (2003) Differential myocardial gene expression in the development and rescue of murine heart failure. Physiological Genomics 15 (2), S. 105-114. Volltext nicht vorhanden.

Grzeskowiak, R., Witt, Henning, Drungowski, M., Thermann, R., Hennig, S., Perrot, A., Osterziel, K., Klingbiel, D., Scheid, Stefanie und Spang, Rainer (2003) Expression profiling of human idiopathic dilated cardiomyopathy. Cardiovascular Research 59, S. 400-411. Volltext nicht vorhanden.

2002

Muller, Tobias, Spang, Rainer und Vingron, M. (2002) Estimating amino acid substitution models: a comparison of Dayhoff's estimator, the resolvent approach and a maximum likelihood method. Molecular Biology and Evolution 19 (1), S. 8-13. Volltext nicht vorhanden.

Spang, Rainer, Rehmsmeier, M. und Stoye, J. (2002) A novel approach to remote homology detection: jumping alignments. Journal of Computational Biology 9 (5), S. 747-760. Volltext nicht vorhanden.

Spang, Rainer, Zuzan, H., West, M., Nevins, J., Blanchette, C. und Marks, J. R. (2002) Prediction and uncertainty in the analysis of gene expression profiles. In Silico Biology 2 (3), S. 369-381. Volltext nicht vorhanden.

2001

West, M., Blanchette, C., Dressman, H., Huang, E., Ishida, S., Spang, Rainer, Zuzan, H., Olson, J. A., Marks, J. R. und Nevins, J. R. (2001) Predicting the clinical status of human breast cancer by using gene expression profiles. Proc. Natl. Acad. Sci. U.S.A. 98 (20), S. 11462-11467. Volltext nicht vorhanden.

Ishida, S., Huang, E., Zuzan, H., Spang, Rainer, Leone, G., West, M. und Nevins, J. R. (2001) Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol. Cell. Biol. 21 (14), S. 4684-4699. Volltext nicht vorhanden.

Spang, Rainer und Vingron, M. (2001) Limits of homology detection by pairwise sequence comparison. Bioinformatics 17 (4), S. 338-342. Volltext nicht vorhanden.

2000

Spang, Rainer, Rehmsmeier, M. und Stoye, J. (2000) Sequence database search using jumping alignments. Proc Int Conf Intell Syst Mol Biol 8, S. 367-375. Volltext nicht vorhanden.

1998

Spang, Rainer und Vingron, M. (1998) Statistics of large-scale sequence searching. Bioinformatics 14 (3), S. 279-284. Volltext nicht vorhanden.

Diese Liste wurde erzeugt am Fri Mar 29 06:44:43 2024 CET.
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