Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft | ||||
Verlag: | Verl. Chemie | ||||
Band: | 229 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 11 | ||||
Seitenbereich: | S. 952-965 | ||||
Datum: | 1966 | ||||
Zusätzliche Informationen (Öffentlich): | CAN 66:49281 64 Pharmaceutical Analysis 299-42-3 Role: ANST (Analytical study) (aminoacyl derivs., sepn. by Craig partition); 90-82-4 (Pseudoephedrine, (+)-) Role: ANST (Analytical study) (aminoacyl derivs., sepn. of, by Craig partition); 2480-20-8; 2673-32-7; 7275-84-5; 14383-64-3; 14482-57-6; 14536-74-4; 14536-75-5; 14536-76-6; 14645-39-7; 14645-40-0; 14680-43-4; 14680-44-5; 14680-45-6; 14980-42-8; 14980-68-8; 14980-69-9; 14980-70-2; 14980-71-3; 14980-72-4; 14980-73-5; 14980-82-6; 14980-84-8; 14980-85-9; 14980-86-0; 15269-48-4 Role: PROC (Process) (sepn. of, by Craig partition) | ||||
Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | Partition (of aminoacylephedrines) Benzyl alcohol Role: PROC (Process) (sepn. of, by Craig partition) AMPHETAMINES SEPN PERVITAMINES SEPN EPHEDRINES SEPN | ||||
Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe | ||||
Dokumenten-ID: | 18149 |
Zusammenfassung
cf. CA 62, 7857h. A series of diastereomeric aminoacylephedrine compds. were sepd. in a Craig phase distribution process in a mixt. of CHCl3, MeOH, and citrate buffer soln. (vol. 10:1:9) at 20 Deg (distribution coeff., K, and sepn. factor, beta = K2/KD, given): (L-N-dimethylphenylalanyl)-L-amphetamine, 1.1, (D-N-dimethylphenylalanyl)-L-amphetamine, 0.75, 1.4; ...
Zusammenfassung
cf. CA 62, 7857h. A series of diastereomeric aminoacylephedrine compds. were sepd. in a Craig phase distribution process in a mixt. of CHCl3, MeOH, and citrate buffer soln. (vol. 10:1:9) at 20 Deg (distribution coeff., K, and sepn. factor, beta = K2/KD, given): (L-N-dimethylphenylalanyl)-L-amphetamine, 1.1, (D-N-dimethylphenylalanyl)-L-amphetamine, 0.75, 1.4; N-(L-N-dimethylphenylalanyl)-L-norephedrine, 2.5, -; (N-(L-N-dimethylphenylalanyl)-D-norephedrine, 0.7, 3.5; N-(L-N-dimethylphenylalanyl)-L-nor-y-ephedrine, 1.2, -; N-(D-N-dimethylphenylalanyl)-L-nor-y-ephedrine, 0.35, 3.4; (L-N-dimethylphenylalanyl)-L-pervitine, 4.3, -; (D-N-dimethylphenylalanyl)-L-pervitine, 4.8, 1.1; N-(D-N-dimethylphenylalanyl)-L-ephedrine, 4.0, -; N-(D-N-dimethylphenylalanyl)-L-ephedrine, 0.87, 3.1; N-(D-N-dimethylphenylalanyl)-L-y-ephedrine, 7.2, -; N-(D-N-dimethylphenylalanyl)-L-y-ephedrine, 0.95, 7.9; N-(L-N-dimethylphenylalanyl)-D-erythro-diphenylethanolamine, 0.62, -; N-(D-N-dimethylphenylalanyl)-D-erythro-diphenylethanolamine, 0.58, 1.07; N-(L-N-dimethylalanyl)-D-threo-diphenylethanolamine, 0.61, -; N-(L-N-dimethylalanyl)-L-threo-diphenylethanolamine, 0.52, 1.17; N-(L-N-dimethylphenylalanyl)-D-erythro-diphenylethanolamine, 1.4, -; N-(D-N-dimethylphenylalanyl)-D-erythro-diphenylethanolamine, 0.35, 4.0; N-(L-N-dimethylphenylalanyl)-D-threo-diphenylethanolamine, 0.9, -; N-(D-N-dimethylphenylalanyl)-D-threo-diphenylethanolamine, 0.51, 1.75. The varying behavior of these compds. is based on interactions between the amide group and the OH group which are exposed to different configurational effects at the three asym. centers of the mol.
Metadaten zuletzt geändert: 24 Mai 2018 12:19