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Zusammenfassung
The D and L enantiomers of phthalyl amino acids I (R = Me, CHMe2, CHPh, indol-3-ylmethyl) and the L enantiomers of I [CH2CHMe2, CH2C6H4(OR)-p (R = H, CH2Ph)] were prepd. in 55.8-83.6% yields by treating phthalic anhydride with the appropriate amino acid for 3-5 min in boiling DMF. The influence of reaction times and R on racemization of L enantiomers of I are given. I were also prepd. in 20-91% ...
Zusammenfassung
The D and L enantiomers of phthalyl amino acids I (R = Me, CHMe2, CHPh, indol-3-ylmethyl) and the L enantiomers of I [CH2CHMe2, CH2C6H4(OR)-p (R = H, CH2Ph)] were prepd. in 55.8-83.6% yields by treating phthalic anhydride with the appropriate amino acid for 3-5 min in boiling DMF. The influence of reaction times and R on racemization of L enantiomers of I are given. I were also prepd. in 20-91% yields by conducting the above reaction for 10-15 min at 150-160 Deg and in 20-68.2% yields by treating N-carboethoxyphthalimide with the appropriate amino acid in aq. Na2CO3.
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