Ovid MEDLINE(R) ALL <1946 to July 29, 2021>

1	exp Platelet-Rich Plasma/	5134
2	Endodontics/ or endodont*.jw. or Root Canal Therapy/ or (Dental Pulp/ or Dental Pulp Cavity/ or exp Tooth Root/) or exp Tooth/	132808
3	(1 and 2) or Regenerative Endodontics/ or ((RET or REP) and endodont*).ti,ab,kf. or ((revitali#ation or revasculari#ation or regenerat* or blood clot* or platelet-rich plasma or platelet-rich fibrin) adj9 (endodont* or pulp* or "root" or tooth or teeth or dens or dentes or canin$ or incisor$ or incisivi or cuspid$ or bicuspid or premolar$ or molar$)).ti,ab,kf. [Regenerative Endodontics]	5848
4	meta-analysis.pt. or (meta-analysis/ or systematic review/ or meta-analysis as topic/ or "meta analysis (topic)"/ or "systematic review (topic)"/ or exp technology assessment, biomedical/) or ((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab,kf,kw. or ((quantitative adj3 (review* or overview* or synthes*)) or (research adj3 (integrati* or overview*))).ti,ab,kf,kw. or ((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab,kf,kw. or (data synthes* or data extraction* or data abstraction*).ti,ab,kf,kw. or (handsearch* or hand search*).ti,ab,kf,kw. or (mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab,kf,kw. or (met analy* or metanaly* or technology assessment* or HTA or HTAs or technology overview* or technology appraisal*).ti,ab,kf,kw. or (meta regression* or metaregression*).ti,ab,kf,kw. or (meta-analy* or metaanaly* or systematic review* or biomedical technology assessment* or bio-medical technology assessment*).mp,hw. or (medline or cochrane or pubmed or medlars or embase or cinahl).ti,ab,hw. or (cochrane or (health adj2 technology assessment) or evidence report).jw. or (comparative adj3 (efficacy or effectiveness)).ti,ab,kf,kw. or (outcomes research or relative effectiveness).ti,ab,kf,kw. or ((indirect or indirect treatment or mixed-treatment) adj comparison*).ti,ab,kf,kw. [CADTH Search Filter for Systematic Reviews/Meta-Analysis/Health Technology Assessment  OVID Medline, Embase]	542837
5	randomized controlled trial.pt.	538895
6	controlled clinical trial.pt.	94314
7	randomized.ab.	528339
8	placebo.ab.	220017
9	clinical trials as topic.sh.	196802
10	randomly.ab.	362499
11	trial.ti.	244465
12	5 or 6 or 7 or 8 or 9 or 10 or 11	1383144
13	exp animals/ not humans.sh.	4867563
14	12 not 13 [Cochrane Highly Sensitive Search Strategy 2008 sensitive and precise MEDLINE Ovid]	1272821
15	exp cohort studies/ or exp epidemiologic studies/ or exp clinical trial/ or exp evaluation studies as topic/ or exp statistics as topic/	5943004
16	((control and (group* or study)) or (time and factors) or program or survey* or ci or cohort or comparative stud* or evaluation studies or follow-up*).mp.	7776641
17	or/15-16	10235315
18	(animals/ not humans/) or comment/ or editorial/ or exp review/ or meta analysis/ or consensus/ or exp guideline/	8879786
19	hi.fs. or case report.mp.	646563
20	or/18-19	9440989
21	17 not 20 [Filter for controlled non-randomized studies with best sensitivity Ovid MEDLINE. Waffenschmidt et al. (2020) https://doi.org/10.1002/jrsm.1425]	7939575
22	3 and 4 [Regenerative Endodontics AND Systematic Reviews, Meta-Analyses]	186
23	3 and 14 [Regenerative Endodontics AND RCTs]	402
24	3 and 21 [Regenerative Endodontics AND Controlled Non-Randomized Studies]	1284
25	or/22-24 [Regenerative Endodontics AND Study Filters]	1513