Data collection forms in folder data_collection_forms/
Figures 1 - 5 in folder figures/
- Figure 1. PRISMA flow diagram; * there were two cases of two records being based on the same study population; from Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021, 372, n71.
- Figure 2. Postoperative development of white blood cell count (WBC), relative change in means with preoperative values set at 100%.
- Figure 3. Forest plot of white blood cell (WBC) count at postoperative day (POD)1, POD4, POD6–8; ⨁⨁ indicates low, ⨁⨁⨁ indicates moderate confidence in estimates of effect; bold numbers indicate the pooled number of participants, pooled mean difference and the pooled 95% confidence interval with the mean difference of each study being indicated by a green square; data from Kvarnström et al. are depicted but not included in the analysis [49–51,53–55,61,62].
- Figure 4. Postoperative development of natural killer (NK) cell count, relative change in means with preoperative values set at 100%.
- Figure 5. Forest plot of natural killer (NK) cell count at postoperative day (POD)1, POD4, POD6–8; ⨁⨁⨁ indicates moderate, ⨁⨁⨁⨁ indicates high confidence in estimates of effect; bold numbers indicate the pooled number of participants, pooled mean difference and the pooled 95% confidence interval with the mean difference of each study being indicated by a green square; [55,57,61,62].
Supplementary Tables S1 - S4
- Table S1: Extensive table of characteristics of included studies; LS = laparoscopic surgery, OS = open surgery; n.a. = information not available; cellular outcomes: WBC = white blood cell count, NKC = natural killer cell count, NKC Akt = natural killer cell activity, Lym = number of total lymphocytes, CD4/8 = ratio odf CD4+/CD8+ T-lymphocytes, HLA-DR II = HLA-DR II expression on CD14+ monocytes, CD3+ or CD4+ or CD8+ = cell count of these lymphocyte subfractions, BC = number of b-lymphocytes, Mono = number of monocytes; eligibility for anallyses: MA = eligible for meta-analysis, G = eligible for graphical display, NA = eligible for narrative synthesis; * data was not included in meta-analysis with absolute numbers because reported results deviated from common values by factor 1000 (Kvarnström et al.) or authors did not report units (Wang et al.).
- Table S2: Table of narrative results; red indicating outcome favouring the open approach, green indicating outcome favouring the laparoscopic approach, n.s. = not significantly differing between groups according to these studies.
- Table S3: Sensitivity analyses of meta-analyses with exclusion of mathematically estimated data.
- Table S4: Risk of bias (RoB) assessments with ratings for each domain.
Supplementary Figures S1 - S5 in folder supplementary_figures/
- Figure S1: Postoperative development of total lymphocyte count relative to preoperative measurements, relative change in means with preoperative values set at 100%.
- Figure S2: Postoperative development of CD4+ T cell count relative to preoperative measurements, relative change in means with preoperative values set at 100%.
- Figure S3: Forest plot of total lymphocyte and CD3+ T lymphocyte counts at postoperative day (POD)1; ⨁⨁⨁ indicates moderate confidence in estimates of effect [50,55,60–62].
- Figure S4: Postoperative development of CD4+/CD8+ ratio relative to preoperative measurements, relative change in means with preoperative values set at 100%.
- Figure S5: Forest plot of CD4+/CD8+ ratio at postoperative day (POD)1, POD3, POD6–8; ⨁⨁⨁ indicates moderate confidence in estimates of effect [48,49,52,60].
PRISMA-2020 Checklist
PRISMA-S Checklist. The full search documentation was published separately, see the article.
