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Oximether-verbrückte Liganden auf Zuckerbasis in der stereoselektiven Hydrierung von Folsäure

Keck, Christian (2005) Oximether-verbrückte Liganden auf Zuckerbasis in der stereoselektiven Hydrierung von Folsäure. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Mar 2005 06:58

Abstract (German)

Neue chirale Liganden wurden dargestellt, indem zur Koordination befähigte Aldehyde und Ketone mit Einfach- und Zweifachzuckern über hydrolysestabile Oximetherbrücken verbunden wurden. Aufgrund ihrer OH-Gruppen sind sie wasserlöslich, während sich ihre acetylierten Analoga in organischen Lösungsmitteln lösen. Die neuen Liganden wurden in homogenen und heterogenisierten Katalysatoren zur ...

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Translation of the abstract (English)

New chiral ligands were synthesized by combining aldehydes and ketones, able for coordination, with mono- and disaccharides via oxime ether bridges stable towards hydrolysis. Due to their OH groups they were water-soluble, whereas their acetylated analogs dissolved in organic solvents. The new ligands were used in homogeneous and heteregenized catalysts for the stereoselective hydrogenation of folic acid, the formylated hydrogenation product of which is the anticancer drug Leucovorine.


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Item type:Thesis of the University of Regensburg (PhD)
Date:13 March 2005
Referee:Henri (Prof. Dr.) Brunner
Date of exam:28 January 2005
Institutions:Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Henri Brunner
Keywords:Katalytische Hydrierung , Folsäure , Oximether , Ligand , , catalytic hydrogenation , folic acid , oximether , ligand
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10293
Owner only: item control page

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