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Enantioselektive Synthese bi- und trizyklischer gamma-Butyrolacton Naturstoff-Analoga

Jezek, Eva (2006) Enantioselektive Synthese bi- und trizyklischer gamma-Butyrolacton Naturstoff-Analoga. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Jul 2006 07:40

Abstract (German)

Von allen bekannten Naturstoffen tragen etwa 10% eine gamma-Butyrolacton-Einheit. Eine einfache, asymmetrische Synthese eines neuen, chlor-funktionalisierten anti-2,3-disubstituierten gamma-Butyrolactons konnte ausgehend von Furancarbonsäuremethylester in einer dreistufigen Reaktionssequenz erzielt werden. Dieses Lacton erwies sich als ein zentraler Baustein in einer hoch diastereoselektiven ...


Translation of the abstract (English)

Gamma-butyrolactones are prominent constituents in biologically active compounds and are found in about 10 % of all natural products. A facile asymmetric synthesis of a novel chloro-functionalized anti 2,3-disubstituted gamma-butyrolactone starting from furan-carboxylicester is presented. This lactone was used as a precursor for a highly diastereoselective radical mediated cyclization strategy ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:2 July 2006
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:29 June 2005
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Totalsynthese , Naturstoff , Butyrolactone , Butyrolactonderivate , Asymmetrische Synthese , , natural product synthesis , butyrolactones , enantioselective synthesis
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10391
Owner only: item control page


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