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Asymmetric methodologies for the construction of 5,7,5- and 6,6,6-tricyclic sesquiterpene lactones towards the synthesis of Arglabin

URN to cite this document:
urn:nbn:de:bvb:355-opus-6860
Jeong, Won Boo
Date of publication of this fulltext: 06 Aug 2007 08:11


Abstract (English)

Many naturally extracted guaianolides (i.e. GLs) and pseudoguaianolides are based on the 5,7,5-fused ring skeleton and they show a broad biological profile. Among them, Arglabin has attracted special attention due to its promising antitumor and cytotoxic activity as an inhibitor of Farnesyltransferase. In the present work the asymmetric synthesis towards Arglabin was investigated via ...

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Translation of the abstract (German)

Viele der identifizierten Naturstoffe der Guaianolide (GLs) und Pseudoguaianolide basieren auf 5,7,5-verknüpften Ring-Systemen und zeigen ein breites biologisches Wirkungsprofil. Des Weiteren ist Arglabin wegen seiner antitumor und cytotoxischen Aktivität als Farnesyltransferase Inhibitor interessant. In der vorliegenden Arbeit wurde die Synthese von Arglabin über ein ...

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