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Characterization of the monocyte to macrophage differentiation (MMD) protein and its homologue MMD2

URN to cite this document:
urn:nbn:de:bvb:355-opus-7131
El Chartouni, Carol
Date of publication of this fulltext: 12 Oct 2007 08:13


Abstract (German)

During the course of this work the monocyte to macrophage differentiation factor (MMD) and its homologue MMD2 were characterized. Both genes encodes for orphan proteins with a predicted seven transmembrane domain very well conserved between species. MMD mRNA expression could be shown to be upregulated in macrophages and to be ubiquitously distributed in mouse and human. In contrast, MMD2 mRNA was ...

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Translation of the abstract (German)

Im Rahmen dieser Arbeit wurde der �Monocyte to Macrophage Differentiation� (MMD) Faktor und dessen Homologes MMD2 charakterisiert. Beide Gene kodieren für ein unbekanntes Sieben-Transmembran-Protein, das zwischen verschiedenen Spezies sehr stark konserviert ist. Es konnte gezeigt werden, dass die MMD-mRNA ubiquitär in Mensch und Maus exprimiert wird und in Makrophagen hochreguliert ist. Im ...

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