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Control of epithelial Na+ channels by CFTR, receptors and kinases

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Bachhuber, Tanja
Date of publication of this fulltext: 30 Jan 2008 16:19

Abstract (English)

The epithelial Na+ channel (ENaC) is located in the apical membrane of salt (re-) absorbing epithelia in kidney, colon, airways and glandular excretory ducts. In this thesis it is demonstrated that both stimulation of purinergic receptors and activation of the cystic fibrosis transmembrane conductance regulator (CFTR) and other Cl- channels lead to inhibition of epithelial Na+ channels, ...


Translation of the abstract (German)

Der epitheliale Na+-Kanal (ENaC) wird in der apikalen Membran von Kochsalz-(re-) absorbierenden Epithelien in Niere, Kolon, Luftwegen und exkretorischen Drüsen exprimiert. In dieser Arbeit wird gezeigt, dass sowohl die Stimulation purinerger Rezeptoren als auch die Aktivierung des cystic fibrosis transmembrane conductance regulator (CFTR) und anderer Cl--Kanäle die Hemmung epithelialer ...


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