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Human pulp-derived cells immortalized with Simian Virus 40 T-antigen

DOI to cite this document:
Galler, Kerstin M. ; Schweikl, Helmut ; Thonemann, Birger ; D'Souza, Rena N. ; Schmalz, Gottfried
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Date of publication of this fulltext: 05 Aug 2009 13:26


Primary cells in culture have a limited capacity to divide and soon reach a non-proliferative state. This cellular senescence limits the investigation of cells derived from human pulp concerning cellular pathways, gene regulation, mechanisms of dentin formation, or responses to material exposure. To overcome this problem, primary human pulp-derived cells were established and transfected with a ...


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