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Transforming growth factor-beta1 is a negative modulator of adult neurogenesis

Wachs, Frank-Peter, Winner, Beate, Couillard-Despres, Sebastien, Schiller, Thorsten, Aigner, Robert, Winkler, Jürgen, Bogdahn, Ulrich and Aigner, Ludwig (2006) Transforming growth factor-beta1 is a negative modulator of adult neurogenesis. Journal of neuropathology and experimental neurology 65 (4), pp. 358-370.

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Other URL: http://dx.doi.org/10.1097/01.jnen.0000218444.53405.f0


Abstract

Transforming growth factor (TGF)-beta1 has multiple functions in the adult central nervous system (CNS). It modulates inflammatory responses in the CNS and controls proliferation of microglia and astrocytes. In the diseased brain, TGF-beta1 expression is upregulated and, depending on the cellular context, its activity can be beneficial or detrimental regarding regeneration. We focus on the role ...

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Item type:Article
Date:April 2006
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.1097/01.jnen.0000218444.53405.f0DOI
16691117PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:1236
Owner only: item control page

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