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Transforming growth factor-beta1 is a negative modulator of adult neurogenesis

Wachs, Frank-Peter ; Winner, Beate ; Couillard-Despres, Sebastien ; Schiller, Thorsten ; Aigner, Robert ; Winkler, Jürgen ; Bogdahn, Ulrich ; Aigner, Ludwig
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

Transforming growth factor (TGF)-beta1 has multiple functions in the adult central nervous system (CNS). It modulates inflammatory responses in the CNS and controls proliferation of microglia and astrocytes. In the diseased brain, TGF-beta1 expression is upregulated and, depending on the cellular context, its activity can be beneficial or detrimental regarding regeneration. We focus on the role ...

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