Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1

DOI to cite this document:: 10.5283/epub.1289

Calzada, Maria J. ; Annis, Douglas S. ; Zeng, Bixi ; Marcinkiewicz, Cezary ; Banas, Bernhard ; Lawler, Jack ; Mosher, Deane F. ; Roberts, David D.

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

In addition to the three known beta(1) integrin recognition sites in the N-module of thrombospondin-1 (TSP1), we found that beta(1) integrins mediate cell adhesion to the type 1 and type 2 repeats. The type 1 repeats of TSP1 differ from typical integrin ligands in that recognition is pan-beta(1)-specific. Adhesion of cells that express one dominant beta(1) integrin on immobilized type 1 repeats ...