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Inhibition of ABC transporters associated with multidrug resistance

Egger, Michael (2010) Inhibition of ABC transporters associated with multidrug resistance. PhD, Universität Regensburg.

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Date of publication of this fulltext: 10 May 2010 08:52

Abstract (English)

The first part of this dissertation (chapters 1 and 2) deals with the inhibition of the ABC transporters ABCB1 (p-glycoprotein) and ABCG2 (breast cancer resistance protein). Less lipophilic and better water soluble analogues of the known ABCB1 inhibitor tariquidar were synthesized from one central building block via Cu(I)-catalyzed N/O-arylation reactions. These compounds were tested for their ...


Translation of the abstract (German)

Im ersten Teil dieser Arbeit (Kapitel 1 und 2) wird die Hemmung der ABC-Transporter ABCB1 (p-Glycoprotein) und ABCG2 (breast cancer resistance protein) beschrieben. Ausgehend von einer zentralen Vorstufe wurden durch Cu(I)-katalysierte N- und O-Arylierungen weniger lipophile und besser wasserlösliche Analoga des ABCB1-Inhibitors Tariquidar synthetisiert. Die inhibitorische Aktivität dieser neuen ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:10 May 2010
Referee:Prof. Dr. Burkhard König
Date of exam:24 April 2009
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Organische Synthese , ABC-Transporter , Forskolin , Igelkopf , Allylierung , N-Arylierung , O-Arylierung , Ketoalkene , N-arylation , O-arylation , ketoalkenes
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13404
Owner only: item control page


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