Go to content
UR Home

Design of peptidomimetics towards new foldamers and 26S proteasome inhibitors

Formicola, Lucia (2010) Design of peptidomimetics towards new foldamers and 26S proteasome inhibitors. PhD, Universität Regensburg.

License: Publishing license for publications excluding print on demand
Download (2MB)
Date of publication of this fulltext: 17 May 2010 07:58

Abstract (English)

The 26S proteasome is a multicatalytic protease complex which is responsible for intracellular protein turnover. The proteasome is a promising target for the development of drugs for the treatment of many different diseases. In the first part of the presented work, we designed and synthesized a new original series of proteasome inhibitors introducing fluorinated peptidomimetics. These compounds ...


Translation of the abstract (German)

Das 26S Proteasome ist ein multikatalytisch aktiver Proteasen Komplex welcher für den intrazellulären Proteinabbau verantwortlich ist. Das Proteasom ist ein vielversprechendes Target für die Entwicklung neuer Medikamente für zahlreiche Erkrankungen. Der erste Teil dieser Arbeit beschäftigt sich mit dem Design und Synthese neuer fluorierter peptidomimetischer Proteasom Inhibitoren. Diese ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:17 May 2010
Referee:Prof. Dr. Oliver Reiser and Prof. Dr. Sames Sicsic
Date of exam:15 December 2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:peptidomimetics, pseudopeptides, foldamers, proteasome, fluorinated scaffold, non covalent inhibitors, solid-phase chemistry
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13410
Owner only: item control page


Downloads per month over past year

  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons