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Enantioselective synthesis of tetrahydrofuran-imidazole based human histamine H3 and H4 receptor agonists

Kashamalla, Chinna Ashalu (2010) Enantioselective synthesis of tetrahydrofuran-imidazole based human histamine H3 and H4 receptor agonists. PhD, Universität Regensburg.

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Date of publication of this fulltext: 11 Oct 2010 08:47

Abstract (English)

A new strategy for the enantioselective synthesis of tetrahydrofuran imidazole based human histamine H3 and H4 receptor potential agonists was designed based on the lead structures imifuramine and OUP-16. In the first part of thesis application of y-butyrolactones for the synthesis of analogues of imifuramine (histamine H3 receptor agonist) and OUP-16 (histamine H4 receptor agonist) was shown ...


Translation of the abstract (German)

Eine neue auf Tetrahydrofuranimidazole basierende Strategie für die enantioselektive Synthese potentieller menschlicher Histamin H3- und H4-Rezeptoragonisten wurde auf Grundlage der Leitstrukturen Imifuramin und OUP-16 entworfen. Im ersten Teil der Arbeit wurde die Verwendung von y-Butyrolactonen für die Synthese von Analogverbindungen des Imifuramins (Histamin H3-Rezeptoragonist) und OUP-16 ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:11 October 2010
Referee:Prof. Dr. Oliver Reiser
Date of exam:2 October 2009
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Interdisciplinary Subject Network:Not selected
Keywords:H3-Rezeptor, H4-Rezeptor, asymmetrische Synthese, Imidazolderivate, enantioselektive Synthese, Tetrahyrofuranimidazol, Histamin H3 und H4 Rezeptorliganden, enantioselective synthesis, tetrahydrofuran-imidazole, histamine H3 and H4 receptor agonists
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13421
Owner only: item control page


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