Macrophage heterogeneity and differentiation: defined serum-free culture conditions induce different types of macrophages in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-142782
DOI to cite this document:: 10.5283/epub.14278

Kreutz, Marina ; Krause, S. W. ; Hennemann, B. ; Rehm, A. ; Andreesen, Reinhard

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Date of publication of this fulltext: 14 Apr 2010 05:19

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Abstract

Macrophages (MAC) are important effector cells of the immune system. They arise from circulating blood monocytes (MO), which undergo further maturation upon leaving the vasculature and migrating into the various tissues and body cavities. A similar differentiation process can be followed in vitro when monocytes are cultured in the presence of serum. In this study, different factors and serum ...