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Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer

Köhne, C. H. ; Schöffski, P. ; Wilke, H. ; Käufer, C. ; Andreesen, Reinhard ; Ohl, U. ; Klaasen, U. ; Westerhausen, M. ; Hiddemann, W. ; Schott, G. ; Harstick, A. ; Bade, J. ; Horster, A. ; Schubert, U. ; Hecker, H. ; Dörken, B. ; Schmoll, H. J.


PURPOSE: To determine whether high-dose infusional fluorouracil (FU) is effectively modulated by leucovorin (LV), interferon (IFN) alpha-2b, or both when given to patients with metastatic colorectal cancer. PATIENTS AND METHODS: Patients (n = 236) with progressive, measurable disease were randomized to three groups and received FU 2,600 mg/m2 as a 24-hour continuous infusion (CI) weekly for 6 ...


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