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Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease

Ewing, Patricia ; Miklos, Sandra ; Olkiewicz, Krystyna M. ; Müller, Gunnar ; Andreesen, Reinhard ; Holler, Ernst ; Cooke, Kenneth R. ; Hildebrandt, Gerhard C.


OBJECTIVE: Tumor necrosis factor alpha (TNFalpha) is an old foe in allogeneic bone marrow transplantation (allo-BMT) promoting acute graft-versus-host disease (aGVHD). We investigated to what extent donor T cells contribute to TNFalpha production. METHODS: Lethally irradiated B6D2F1 mice were transplanted with bone marrow (BM) and T cells from syngeneic B6D2F1 or allogeneic B6 donors and assessed ...


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