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Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease

Ewing, Patricia, Miklos, Sandra, Olkiewicz, Krystyna M., Müller, Gunnar, Andreesen, Reinhard, Holler, Ernst, Cooke, Kenneth R. and Hildebrandt, Gerhard C. (2007) Donor CD4+ T-cell production of tumor necrosis factor alpha significantly contributes to the early proinflammatory events of graft-versus-host disease. Experimental hematology 35 (1), pp. 155-63.

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Abstract

OBJECTIVE: Tumor necrosis factor alpha (TNFalpha) is an old foe in allogeneic bone marrow transplantation (allo-BMT) promoting acute graft-versus-host disease (aGVHD). We investigated to what extent donor T cells contribute to TNFalpha production. METHODS: Lethally irradiated B6D2F1 mice were transplanted with bone marrow (BM) and T cells from syngeneic B6D2F1 or allogeneic B6 donors and assessed ...

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Item type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
17198884PubMed ID
10.1016/j.exphem.2006.09.012DOI
Classification:
NotationType
AnimalsMESH
Bone Marrow Transplantation/adverse effectsMESH
CD4-Positive T-Lymphocytes/transplantationMESH
CD8-Positive T-LymphocytesMESH
Graft vs Host Disease/pathologyMESH
Inflammation/etiologyMESH
KineticsMESH
MiceMESH
Mice, Inbred StrainsMESH
Survival RateMESH
T-Lymphocytes/transplantationMESH
Tissue DonorsMESH
Transplantation, HomologousMESH
Transplantation, IsogeneicMESH
Tumor Necrosis Factor-alpha/physiologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14497
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