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Structural investigations on N'-substituted N-acylguanidines - Intermolecular interactions with solvents, anions and receptors

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Kleinmaier, Roland
Date of publication of this fulltext: 30 May 2011 06:11

Abstract (English)

Acylguanidines are an abundant class of compounds with various applications in organic and pharmaceutical chemistry. Within the subgroup of N’-substituted and especially monoalkylated N-acylguanidines, highly potent and selective ligands for G protein coupled receptors have been identified in recent years. In the field of molecular recognition, acylguanidines are valued for their ability to form ...


Translation of the abstract (German)

Acylguanidine stellen eine vielfältig vertretene Verbindungsklasse dar, die breite Verwendung in der organischen und pharmazeutischen Chemie findet. In den vergangenen Jahren wurden zahlreiche biologisch aktive Substanzen entwickelt, die die Substruktur des monoalkylierten Acylguanidins enthalten, darunter hochpotente und selektive Liganden zur Bindung an G-Protein-gekoppelte Rezeptoren, sowie ...


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