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Effect of fluoride on aluminum-induced bone disease in rats with renal failure

Ittel, T. H., Gruber, E., Heinrichs, A., Handt, S., Hofstädter, Ferdinand and Sieberth, H.G. (1992) Effect of fluoride on aluminum-induced bone disease in rats with renal failure. Kidney international 41 (5), pp. 1340-1348.

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Abstract

Aluminum (Al) accumulation in renal failure is an etiological factor in the pathogenesis of low turnover bone disease. Aluminum-induced impairment of mineralization has been related to a reduced extent of active bone-forming surface. The present study investigated the effect of fluoride, a potent stimulator of osteoblast number, on the toxicity of aluminum in rats with renal failure (Nx). ...

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Item type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
1614048PubMed ID
Classification:
NotationType
Aluminum/toxicityMESH
AnimalsMESH
Bone Diseases/pathologyMESH
Fluorides/pharmacologyMESH
Kidney Failure, Chronic/complicationsMESH
MaleMESH
Minerals/metabolismMESH
Osteoblasts/pathologyMESH
Osteomalacia/pathologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:15257
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