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Effect of fluoride on aluminum-induced bone disease in rats with renal failure

Ittel, T. H. ; Gruber, E. ; Heinrichs, A. ; Handt, S. ; Hofstädter, Ferdinand ; Sieberth, H.G.



Abstract

Aluminum (Al) accumulation in renal failure is an etiological factor in the pathogenesis of low turnover bone disease. Aluminum-induced impairment of mineralization has been related to a reduced extent of active bone-forming surface. The present study investigated the effect of fluoride, a potent stimulator of osteoblast number, on the toxicity of aluminum in rats with renal failure (Nx). ...

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