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Laser microdissection and microsatellite analyses of breast cancer reveal a high degree of tumor heterogeneity

Wild, P. ; Knuechel, R. ; Dietmaier, W. ; Hofstaedter, Ferdinand ; Hartmann, A.


Carcinomas with productive fibrosis are the most common forms of breast cancer. Analysis of tumor-specific genomic alterations can be compromised by the presence of normal cells, demanding microdissection of small tumor areas to detect loss of heterozygosity (LOH) and microsatellite instability (MSI). The aim of this study was to evaluate the importance of precise laser microdissection for ...


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