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Characterization of a novel M-CSF induced effector macrophage

URN to cite this document:
urn:nbn:de:bvb:355-epub-156856
Riedhammer, Sebastian Matthias
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Dissertation Sebastian Riedhammer 2010
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Date of publication of this fulltext: 15 Jul 2010 14:23


Abstract (English)

The results of this study establish that monocyte adhesion, which undoubtedly is responsible for many substantial changes in the monocyte, is not essential for monocyte survival and differentiation to a macrophage-like cell. As monocytes and their dfferentiated forms are found, not only in the extra cellular matrix, but also in suspension in the blood and the peritoneal fluid, this can help to ...

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Translation of the abstract (German)

Monozyten und die aus ihnen hervorgehenden Makrophagen und dendritischen Zellen (DC) haben im Immunsystem des Menschen eine besondere Rolle als Bindeglied zwischen dem angeborenen und dem adaptiven Immunsystem. In vielen Experimenten zur Differenzierung von Makrophagen aus Monozyten erwies sich der Wachstumsfaktor M-CSF als überlebensnotwendig. Dabei wurden jedoch die Monozyten stets adhärent ...

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