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PGE2 hemmt die Migration intestinaler Myofibroblasten

Georgieva, Martina (2010) PGE2 hemmt die Migration intestinaler Myofibroblasten. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Jul 2010 09:48

Abstract (German)

Die chronisch entzündlichen Darmerkrankungen (CED) sind eine multifaktoriell bedingte Störung, die durch chronischen Schaden der intestinalen Epithelzellschicht und des tiefer liegenden Bindegewebes charakterisiert ist. Die Ätiologie der chronisch entzündlichen Darmkrankheiten Morbus Crohn und Colitis Ulcerosa ist vielschichtig und bisher noch weitgehend unbekannt. Die Migration und die ...


Translation of the abstract (English)

Background: Migration of colonic lamina propria fibroblasts (CLPF) is an important mechanism during wound healing in inflammatory bowel disease (IBD). The concentration of prostaglandin E2 (PGE2) is increased in the intestinal mucosa of IBD patients. This study therefore investigated the role of PGE2 in CLPF migration. Methods: Primary cultures of CLPF were isolated from healthy controls and ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:16 July 2010
Referee:Prof. Dr. Dr. Gerhard Rogler and PD Dr. Frauke Bataille
Date of exam:24 June 2010
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Keywords:Fibroblast, Fibrose, PGE2, Migration, CED, fibroblast, fibrosis, PGE2, migration, Crohn’s disease
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:15699
Owner only: item control page


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