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Modulation of conformational equilibria of human H-Ras protein by metal-chelate derivatives and high pressure studied by NMR spectroscopy

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Rosnizeck, Ina
Date of publication of this fulltext: 05 Jul 2011 06:35

Abstract (English)

The small guanine nucleotide binding protein Ras is essentially involved in the regulation of cell proliferation, differentiation and apoptosis. Alternating between an inactive GDP and an active GTP-bound form, Ras acts as molecular switch. Only active Ras can bind different effectors and transduce the signal. In about 30% of all human tumors Ras is locked in the active GTP-bound form, which ...


Translation of the abstract (German)

Das kleine Guaninnukleotid-bindende Protein Ras ist essentiell an der Regulierung der Proliferation, Differenzierung und Apoptose von Zellen beteiligt. Es fungiert als molekularer Schalter indem es zwischen einer inkativen Form, gebunden an GDP und einer aktiven Form, gebunden an GTP wechselt. Nur aktives Ras kann verschiedene Effektoren binden und somit Signale weiterleiten. In circa 30% aller ...


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