Only the chemotactic subpopulation of human blood monocytes expresses receptors for the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine

URN to cite this document:: urn:nbn:de:bvb:355-epub-159656
DOI to cite this document:: 10.5283/epub.15965

Falk, Werner ; Harvath, L. ; Leonard, E.J.

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Date of publication of this fulltext: 20 Jul 2010 09:13

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Abstract

Human peripheral blood monocytes comprise a subpopulation of 20 to 40% that is capable of responding to chemoattractants and a remaining subpopulation that cannot respond. We were able to obtain 99%-pure attractant-responsive monocytes by using a newly constructed separation chamber. The binding of the radioactive chemotactic peptide N-formylmethionyl-leucyl-[3H]phenylalanine to migrating and ...