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Layer by Layer fabricated gold nanoparticles for nucleic acid delivery

Elbakry, Asmaa Mohamed (2012) Layer by Layer fabricated gold nanoparticles for nucleic acid delivery. PhD, Universität Regensburg.

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Date of publication of this fulltext: 25 Sep 2012 09:34

Abstract (English)

The delivery of nucleic acids to cells has gained significant attention and shown tremendous promise for the treatment of genetic and acquired diseases. The delivery of siRNA into cells requires a carrier, since the siRNA is prone to enzymatic degradation, very large, and too negatively charged to cross cellular membranes. Common approaches for siRNA delivery include the creation of nanoparticles ...

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Translation of the abstract (German)

Der Transport von Nukleinsäuren in Zellen hat großes Interesse erlangt und zeigt enorm vielversprechende Möglichkeiten zur Behandlung von genetischen und erworbenen Krankheiten auf. Die Überführung von siRNA in Zellen erfordert einen Träger, da die siRNA zum einen sehr groß und anfällig für den enzymatischen Abbau ist, und zum anderen zu negativ geladen um Zellmembranen zu durchqueren. Übliche ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:25 September 2012
Referee:Prof. Dr. Achim Göpferich
Date of exam:17 September 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Interdisciplinary Subject Network:Not selected
Keywords:layer-by-layer, gold nanoparticles, polyelectrolyte, siRNA delivery
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:16473
Owner only: item control page

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