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Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen

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Oehm, A. ; Behrmann, I. ; Falk, Werner ; Pawlita, M. ; Maier, G. ; Klas, C. ; Li-Weber, M. ; Richards, S. ; Dhein, J. ; Trauth, B. C.
Date of publication of this fulltext: 08 Sep 2010 05:17


The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 was previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. Cross-linking of the APO-1 antigen by anti-APO-1 induced programmed cell death, apoptosis, of APO-1 positive cells. To characterize the APO-1 cell surface molecule and to ...


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