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NMR structure of inactivation gates from mammalian voltage-dependent potassium channels

Antz, C. ; Geyer, M. ; Fakler, B. ; Schott, M. K. ; Guy, H. R. ; Franke, R. ; Ruppersberg, J. P. ; Kalbitzer, Hans Robert



Abstract

The electrical signalling properties of neurons originate largely from the gating properties of their ion channels. N-type inactivation of voltage-gated potassium (Kv) channels is the best-understood gating transition in ion channels, and occurs by a 'ball-and-chain' type mechanism. In this mechanism an N-terminal domain (inactivation gate), which is tethered to the cytoplasmic side of the ...

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