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Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe

Gronwald, W. ; Huber, F. ; Grünewald, P. ; Spörner, M. ; Wohlgemuth, S. ; Herrmann, C. ; Kalbitzer, Hans Robert



Abstract

BACKGROUND: After activation, small GTPases such as Ras transfer the incoming signal to effectors by specifically interacting with the binding domain of these proteins. Structural details of the binding domain of different effectors determine which pathway is predominantly activated. Byr2 from fission yeast is a functional homolog of Raf, which is the direct downstream target of Ras in mammalians ...

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