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Ex vivo/in vitro absorption of STW 5 (Iberogast) and its extract components

Kelber, O., Wittwer, A., Lapke, C., Kroll, U., Weiser, D., Okpanyi, S. N. and Heilmann, Jörg (2006) Ex vivo/in vitro absorption of STW 5 (Iberogast) and its extract components. Phytomedicine 13 (Suppl.), pp. 107-113.

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Abstract

To correlate the pharmacol. effects of the fixed herbal combination STW 5 (Iberogast) contg. nine ext. components with its confirmed clin. efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco-2-cell model were used. The absorption rate of the exts. was detd. by measuring characteristic marker substances of ...

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Item type:Article
Date:2006
Additional Information (public):CAN 146:394269 1-2 Pharmacology 99-49-0 (Carvone) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Carum carvi ext. carvone showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 99-32-1 (Chelidonic acid) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Chelidonium majus ext. chelidonic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 1405-86-3 (Glycyrrhizic acid) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Glycyrhiza glabra ext. glycyrrhizic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 554-88-1 (Glucoiberin); 2222-07-3; 18444-66-1 (Cucurbitacine E) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Iberis amara ext. glucoberin, cucurbitamine E and I showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 371973-50-1 (Iberogast) Role: NPO (Natural product occurrence), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), OCCU (Occurrence), USES (Uses) (Iberogast contg. Iberis, Matricaria, Carum, Silybum, Melissa, Mentha, Chelidonium, Glycyrhiza, Angelicae ext. showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 22567-36-8 (Bisabololoxide A) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Matricaria reticulata ext. bisabololoxide A showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 20283-92-5 (Rosmarinic acid) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Melissa officinalis ext. rosamarinic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 1490-04-6 (Menthol) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Mentha piperita ext. menthol showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell); 22888-70-6 (Silibinin) Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Iberogast contg. Silybum marianum ext. silibinin showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2007:280058Other
Keywords:Angelica archangelica (Iberogast contg. Angelicae radix ext. showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Carum carvi (Iberogast contg. Carum carvi ext. carvone showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Chelidonium majus (Iberogast contg. Chelidonium majus ext. chelidonic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Glycyrrhiza glabra (Iberogast contg. Glycyrhiza glabra ext. glycyrrhizic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Iberis amara (Iberogast contg. Iberis amara ext. glucoberin, cucurbitamine E and I showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Bioavailability Human (Iberogast contg. Iberis, Matricaria, Carum, Silybum, Melissa, Mentha, Chelidonium, Glycyrhiza, Angelicae ext. showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Matricaria chamomilla (Iberogast contg. Matricaria reticulata ext. bisabololoxide A showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Melissa officinalis (Iberogast contg. Melissa officinalis ext. rosamarinic acid showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Mentha piperita (Iberogast contg. Mentha piperita ext. menthol showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Silybum marianum (Iberogast contg. Silybum marianum ext. silibinin showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Adenocarcinoma Colon neoplasm (colon adenocarcinoma Iberogast contg. Iberis, Matricaria, Carum, Silybum, Melissa, Mentha, Chelidonium, Glycyrhiza, Angelicae ext. showed good bioavailability, therapeutic efficacy in human adenocarcinoma cell) Iberogast natural pharmaceutical absorption bioavailability colon adenocarcinoma
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17228
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