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Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells

Kraus, Birgit, Wolff, Horst, Heilmann, Jörg and Elstner, Erich F. (2007) Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life sciences 81 (11), pp. 884-894.

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Abstract

As immunocompetent cells of the brain, microglia are able to counteract the damaging effects of amyloid-beta in Alzheimer's disease by phagocytosis-mediated clearance of protein aggregates. The survival and health of microglia are therefore crit. for attenuating and preventing neurodegenerative diseases. In a microglial cell line pretreated with St. John's wort (Hypericum perforatum L.) ext. ...

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Item type:Article
Date:2007
Additional Information (public):CAN 148:24236 1-11 Pharmacology 7782-44-7D (Oxygen) Role: BSU (Biological study, unclassified), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia); 117-39-5 (Quercetin); 153-18-4 (Rutin); 154-23-4 ((+)-Catechin); 482-36-0 (Hyperosid); 490-46-0 ((-)-Epicatechin); 522-12-3 (Quercitrin) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2007:1045807Other
Keywords:Alzheimer disease Anti-Alzheimer's agents Antioxidants Hypericum perforatum Phagocytosis (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) beta -Amyloid Role: ADV (Adverse effect, including toxicity), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Reactive oxygen species Role: BSU (Biological study, unclassified), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Flavanols Flavonoids Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Cell membrane (fluidity Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Neuroglia (microglia Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Hypericum perforatum ext compd amyloid toxicity microglia Alzheimer's
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17232
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