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Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells

Kraus, Birgit ; Wolff, Horst ; Heilmann, Jörg ; Elstner, Erich F.



Abstract

As immunocompetent cells of the brain, microglia are able to counteract the damaging effects of amyloid-beta in Alzheimer's disease by phagocytosis-mediated clearance of protein aggregates. The survival and health of microglia are therefore crit. for attenuating and preventing neurodegenerative diseases. In a microglial cell line pretreated with St. John's wort (Hypericum perforatum L.) ext. ...

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