Startseite UR

Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells

Kraus, Birgit, Wolff, Horst, Heilmann, Jörg und Elstner, Erich F. (2007) Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life sciences 81 (11), S. 884-894.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.


Zusammenfassung

As immunocompetent cells of the brain, microglia are able to counteract the damaging effects of amyloid-beta in Alzheimer's disease by phagocytosis-mediated clearance of protein aggregates. The survival and health of microglia are therefore crit. for attenuating and preventing neurodegenerative diseases. In a microglial cell line pretreated with St. John's wort (Hypericum perforatum L.) ext. ...

plus


Bibliographische Daten exportieren



Dokumentenart:Artikel
Datum:2007
Zusätzliche Informationen (Öffentlich):CAN 148:24236 1-11 Pharmacology 7782-44-7D (Oxygen) Role: BSU (Biological study, unclassified), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia); 117-39-5 (Quercetin); 153-18-4 (Rutin); 154-23-4 ((+)-Catechin); 482-36-0 (Hyperosid); 490-46-0 ((-)-Epicatechin); 522-12-3 (Quercitrin) Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2007:1045807Andere
Stichwörter / Keywords:Alzheimer disease Anti-Alzheimer's agents Antioxidants Hypericum perforatum Phagocytosis (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) beta -Amyloid Role: ADV (Adverse effect, including toxicity), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Reactive oxygen species Role: BSU (Biological study, unclassified), BIOL (Biological study) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Flavanols Flavonoids Role: DMA (Drug mechanism of action), PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Cell membrane (fluidity Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Neuroglia (microglia Hypericum perforatum ext. and compds. effect on amyloid-beta -mediated toxicity in microglia) Hypericum perforatum ext compd amyloid toxicity microglia Alzheimer's
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 13:19
Zuletzt geändert:24 Mai 2018 12:16
Dokumenten-ID:17232
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de

Dissertationen: dissertationen@ur.de

Forschungsdaten: daten@ur.de

Ansprechpartner