Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties
Decker, Michael, Kraus, Birgit und Heilmann, Jörg (2008) Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties. Bioorganic & medicinal chemistry 16 (8), S. 4252-4261.Veröffentlichungsdatum dieses Volltextes: 18 Okt 2010 13:28
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| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Bioorganic & medicinal chemistry | ||||
| Verlag: | Elsevier | ||||
|---|---|---|---|---|---|
| Band: | 16 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 | ||||
| Seitenbereich: | S. 4252-4261 | ||||
| Datum | 2008 | ||||
| Zusätzliche Informationen (Öffentlich) | CAN 149:464 1-3 Pharmacology 9000-81-1 (Acetylcholinesterase) Role: BSU (Biological study, unclassified), BIOL (Biological study) (hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties); 1029034-02-3P; 1029034-03-4P; 1029034-04-5P; 1029034-05-6P; 1029034-06-7P; 1029034-07-8P; 1029034-08-9P; 1029034-09-0P; 1029034-10-3P; 1029034-11-4P; 1029034-12-5P; 1029034-13-6P; 1029034-14-7P; 1029034-15-8P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties); 745837-16-5; 911366-60-4 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties); 109-76-2 (1,3-Propanediamine); 110-60-1 (1,4-Butanediamine); 124-09-4 (1,6-Hexanediamine); 373-44-4 (1,8-Octanediamine); 462-94-2 (1,5-Pentanediamine); 646-19-5 (1,7-Heptanediamine); 1200-22-2 (Lipoic acid); 881890-07-9; 911366-48-8 Role: RCT (Reactant), RACT (Reactant or reagent) (hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties); 9001-08-5 (Butyrylcholinesterase) Role: BSU (Biological study, unclassified), BIOL (Biological study) (inhibitors; hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties) | ||||
| Institutionen | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | Antioxidants Cholinesterase inhibitors Structure-activity relationship (hybrid mols. of quinazolinimines and lipoic acid as butyrylcholinesterase inhibitors with antioxidant properties) butyrylcholinesterase inhibitor antioxidant quinazolinimine lipoate prepn SAR | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| Dokumenten-ID | 17237 |
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