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Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties

Decker, Michael ; Kraus, Birgit ; Heilmann, Jörg


A set of hybrid mols. were synthesized out of lipoic acid, alpha ,w-diamines of different lengths serving as spacers, and cholinesterase (ChE) inhibiting [2,1-b]quinazolinimines. Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6 micro M and inhibitors of butyrylcholinesterase (BChE) with activities ...


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