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Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents

Rook, Yvonne, Schmidtke, Kai-Uwe, Gaube, Friedemann, Schepmann, Dirk, Wuensch, Bernhard, Heilmann, Jörg, Lehmann, Jochen and Winckler, Thomas (2010) Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents. Journal of medicinal chemistry 53 (9), pp. 3611-3617.

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Abstract

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with multifactorial causes that requires multitargeted treatment. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) improve cholinergic signaling in the central nervous system and thus AChE inhibitors are well established in the therapy of AD to improve memory disturbances and other cognitive symptoms. On ...

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Item type:Article
Date:2010
Additional Information (public):CAN 152:516583 1-3 Pharmacology 9000-81-1 (Acetylcholinesterase); 9001-08-5 Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 103800-21-1P; 1225056-56-3P; 1225056-70-1P; 1225056-71-2P; 1225056-72-3P; 1225056-73-4P; 1225056-74-5P; 1225056-75-6P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 244-63-3 (9H-Pyrido[3,4-b]indole); 30684-42-5; 58982-28-8 (9H-Pyrido[3,4-b]indol-6-ol) Role: PAC (Pharmacological activity), RCT (Reactant), THU (Therapeutic use), BIOL (Biological study), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 5667-11-8P; 53952-75-3P; 950993-91-6P; 1225056-47-2P; 1225056-48-3P; 1225056-49-4P; 1225056-50-7P; 1225056-51-8P; 1225056-52-9P; 1225056-53-0P; 1225056-54-1P; 1225056-55-2P; 1225056-57-4P; 1225056-58-5P; 1225056-59-6P; 1225056-60-9P; 1225056-61-0P; 1225056-62-1P; 1225056-63-2P; 1225056-64-3P; 1225056-65-4P; 1225056-68-7P; 1225056-69-8P; 1225056-76-7P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 7212-59-1; 16502-01-5 (1,2,3,4-Tetrahydro-beta -carboline); 20315-68-8 (6-Methoxy-1,2,3,4-Tetrahydro-beta -carboline); 30684-43-6; 59444-69-8 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 74-88-4 (Methyl iodide); 110-52-1; 110-86-1 (Pyridine); 111-24-0; 112-60-7; 623-24-5; 629-03-8 (1,6-Dibromohexane); 629-27-6; 3344-70-5; 4101-68-2; 4549-31-9; 4549-32-0; 4549-33-1; 16696-65-4; 746549-76-8 Role: RCT (Reactant), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 31255-26-2P; 1225056-66-5P; 1225056-67-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
2010:421734Other
Keywords:Alzheimer disease Cognitive disorders Enzyme inhibitors NMDA receptor antagonists Neurodegenerative disease Structure-activity relationship (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) NMDA receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) Toxins Role: BSU (Biological study, unclassified), BIOL (Biological study) (excitotoxins bivalent beta -carbolines as potential multitarget anti-alzheimer agents) acetylcholinesterase inhibitor NMDA Alzheimers disease carboline deriv SAR prepn
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17255
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