Startseite UR

Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents

Rook, Yvonne, Schmidtke, Kai-Uwe, Gaube, Friedemann, Schepmann, Dirk, Wuensch, Bernhard, Heilmann, Jörg, Lehmann, Jochen und Winckler, Thomas (2010) Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents. Journal of medicinal chemistry 53 (9), S. 3611-3617.

Im Publikationsserver gibt es leider keinen Volltext zu diesem Eintrag.


Zusammenfassung

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with multifactorial causes that requires multitargeted treatment. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) improve cholinergic signaling in the central nervous system and thus AChE inhibitors are well established in the therapy of AD to improve memory disturbances and other cognitive symptoms. On ...

plus


Bibliographische Daten exportieren



Dokumentenart:Artikel
Datum:2010
Zusätzliche Informationen (Öffentlich):CAN 152:516583 1-3 Pharmacology 9000-81-1 (Acetylcholinesterase); 9001-08-5 Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 103800-21-1P; 1225056-56-3P; 1225056-70-1P; 1225056-71-2P; 1225056-72-3P; 1225056-73-4P; 1225056-74-5P; 1225056-75-6P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 244-63-3 (9H-Pyrido[3,4-b]indole); 30684-42-5; 58982-28-8 (9H-Pyrido[3,4-b]indol-6-ol) Role: PAC (Pharmacological activity), RCT (Reactant), THU (Therapeutic use), BIOL (Biological study), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 5667-11-8P; 53952-75-3P; 950993-91-6P; 1225056-47-2P; 1225056-48-3P; 1225056-49-4P; 1225056-50-7P; 1225056-51-8P; 1225056-52-9P; 1225056-53-0P; 1225056-54-1P; 1225056-55-2P; 1225056-57-4P; 1225056-58-5P; 1225056-59-6P; 1225056-60-9P; 1225056-61-0P; 1225056-62-1P; 1225056-63-2P; 1225056-64-3P; 1225056-65-4P; 1225056-68-7P; 1225056-69-8P; 1225056-76-7P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 7212-59-1; 16502-01-5 (1,2,3,4-Tetrahydro-beta -carboline); 20315-68-8 (6-Methoxy-1,2,3,4-Tetrahydro-beta -carboline); 30684-43-6; 59444-69-8 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 74-88-4 (Methyl iodide); 110-52-1; 110-86-1 (Pyridine); 111-24-0; 112-60-7; 623-24-5; 629-03-8 (1,6-Dibromohexane); 629-27-6; 3344-70-5; 4101-68-2; 4549-31-9; 4549-32-0; 4549-33-1; 16696-65-4; 746549-76-8 Role: RCT (Reactant), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 31255-26-2P; 1225056-66-5P; 1225056-67-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents)
Institutionen:Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann)
Identifikationsnummer:
WertTyp
2010:421734Andere
Stichwörter / Keywords:Alzheimer disease Cognitive disorders Enzyme inhibitors NMDA receptor antagonists Neurodegenerative disease Structure-activity relationship (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) NMDA receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) Toxins Role: BSU (Biological study, unclassified), BIOL (Biological study) (excitotoxins bivalent beta -carbolines as potential multitarget anti-alzheimer agents) acetylcholinesterase inhibitor NMDA Alzheimers disease carboline deriv SAR prepn
Dewey-Dezimal-Klassifikation:500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
500 Naturwissenschaften und Mathematik > 540 Chemie
Status:Veröffentlicht
Begutachtet:Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:Ja
Eingebracht am:18 Okt 2010 14:08
Zuletzt geändert:08 Mrz 2017 08:27
Dokumenten-ID:17255
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de

Dissertationen: dissertationen@ur.de

Forschungsdaten: daten@ur.de

Ansprechpartner