Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents
Rook, Yvonne, Schmidtke, Kai-Uwe, Gaube, Friedemann, Schepmann, Dirk, Wuensch, Bernhard, Heilmann, Jörg, Lehmann, Jochen und Winckler, Thomas (2010) Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents. Journal of medicinal chemistry 53 (9), S. 3611-3617.Veröffentlichungsdatum dieses Volltextes: 18 Okt 2010 14:08
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| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Journal of medicinal chemistry | ||||
| Verlag: | American Chemical Society | ||||
|---|---|---|---|---|---|
| Band: | 53 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 9 | ||||
| Seitenbereich: | S. 3611-3617 | ||||
| Datum | 2010 | ||||
| Zusätzliche Informationen (Öffentlich) | CAN 152:516583 1-3 Pharmacology 9000-81-1 (Acetylcholinesterase); 9001-08-5 Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 103800-21-1P; 1225056-56-3P; 1225056-70-1P; 1225056-71-2P; 1225056-72-3P; 1225056-73-4P; 1225056-74-5P; 1225056-75-6P Role: PAC (Pharmacological activity), RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 244-63-3 (9H-Pyrido[3,4-b]indole); 30684-42-5; 58982-28-8 (9H-Pyrido[3,4-b]indol-6-ol) Role: PAC (Pharmacological activity), RCT (Reactant), THU (Therapeutic use), BIOL (Biological study), USES (Uses), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 5667-11-8P; 53952-75-3P; 950993-91-6P; 1225056-47-2P; 1225056-48-3P; 1225056-49-4P; 1225056-50-7P; 1225056-51-8P; 1225056-52-9P; 1225056-53-0P; 1225056-54-1P; 1225056-55-2P; 1225056-57-4P; 1225056-58-5P; 1225056-59-6P; 1225056-60-9P; 1225056-61-0P; 1225056-62-1P; 1225056-63-2P; 1225056-64-3P; 1225056-65-4P; 1225056-68-7P; 1225056-69-8P; 1225056-76-7P Role: PAC (Pharmacological activity), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 7212-59-1; 16502-01-5 (1,2,3,4-Tetrahydro-beta -carboline); 20315-68-8 (6-Methoxy-1,2,3,4-Tetrahydro-beta -carboline); 30684-43-6; 59444-69-8 Role: PAC (Pharmacological activity), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 74-88-4 (Methyl iodide); 110-52-1; 110-86-1 (Pyridine); 111-24-0; 112-60-7; 623-24-5; 629-03-8 (1,6-Dibromohexane); 629-27-6; 3344-70-5; 4101-68-2; 4549-31-9; 4549-32-0; 4549-33-1; 16696-65-4; 746549-76-8 Role: RCT (Reactant), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents); 31255-26-2P; 1225056-66-5P; 1225056-67-6P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) | ||||
| Institutionen | Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische Biologie (Prof. Heilmann) | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | Alzheimer disease Cognitive disorders Enzyme inhibitors NMDA receptor antagonists Neurodegenerative disease Structure-activity relationship (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) NMDA receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (bivalent beta -carbolines as potential multitarget anti-alzheimer agents) Toxins Role: BSU (Biological study, unclassified), BIOL (Biological study) (excitotoxins bivalent beta -carbolines as potential multitarget anti-alzheimer agents) acetylcholinesterase inhibitor NMDA Alzheimers disease carboline deriv SAR prepn | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| Dokumenten-ID | 17255 |
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