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Bivalent beta -Carbolines as Potential Multitarget Anti-Alzheimer Agents

Rook, Yvonne ; Schmidtke, Kai-Uwe ; Gaube, Friedemann ; Schepmann, Dirk ; Wuensch, Bernhard ; Heilmann, Jörg ; Lehmann, Jochen ; Winckler, Thomas



Abstract

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with multifactorial causes that requires multitargeted treatment. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) improve cholinergic signaling in the central nervous system and thus AChE inhibitors are well established in the therapy of AD to improve memory disturbances and other cognitive symptoms. On ...

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