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Development of selective, active platinum complexes

Schönenberger, Helmut, Wappes, B., Jennerwein, M. and Berger, M. (1984) Development of selective, active platinum complexes. Contributions to oncology = Beiträge zur Onkologie 18 (Resist), pp. 48-57.

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The development of Pt-complexes of the type 1,2-bis(4-hydroxyphenyl)ethylenediamines as ligands for estrogen receptors of receptor-pos. and -neg. mammary cancer cells is discussed. The degree of receptor affinity of the ligand was dependent on its configuration, i.e. the R,R- and the S,S-conformations, in contrast to the R,S conformation, were more effective for inhibition of estradiol-receptor ...


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Item type:Article
Additional Information (public):CAN 102:89669 1-3 Pharmacology 7440-06-4D; 91265-66-6; 91326-62-4; 91326-63-5 Role: BIOL (Biological study) (neoplasm inhibitory activity of, estrogen receptor interaction and structure in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Receptors Role: BIOL (Biological study) (estrogen, platinum complexes interaction with, neoplasm-inhibiting activity in relation to) Neoplasm inhibitors (platinum complexes) Molecular structure-biological activity relationship (neoplasm-inhibiting, of platinum complexes) platinum complex antitumor structure estrogen receptor platinum complex antitumor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17649
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