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Development of selective, active platinum complexes

Schönenberger, Helmut ; Wappes, B. ; Jennerwein, M. ; Berger, M.


The development of Pt-complexes of the type 1,2-bis(4-hydroxyphenyl)ethylenediamines as ligands for estrogen receptors of receptor-pos. and -neg. mammary cancer cells is discussed. The degree of receptor affinity of the ligand was dependent on its configuration, i.e. the R,R- and the S,S-conformations, in contrast to the R,S conformation, were more effective for inhibition of estradiol-receptor ...


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