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Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes

Gust, Ronald, Schönenberger, Helmut, Kritzenberger, Juergen, Range, Klaus Juergen, Klement, Ulrich and Burgemeister, Thomas (1993) Crystal structure, solution chemistry, and antitumor activity of diastereomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complexes. Inorganic chemistry 32 (26), pp. 5939-5950.

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Complete 3-dimensional x-ray crystal structure analyses of meso- and S,S-PtCl2L (L = 1,2-bis(2-hydroxyphenyl)ethylenediamine] (I and II, resp.) were carried out. After anisotropic refinement of F-values by least squares, R is 0.098 for I and 0.048 for II. I and II crystallize with Z = 4, monoclinic symmetry and space group P21/n for I and space group P21 for II. I and II build dimeric units. The ...


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Item type:Article
Additional Information (public):CAN 120:22364 78-7 Inorganic Chemicals and Reactions 20461-54-5 (Iodide) Role: RCT (Reactant), RACT (Reactant or reagent) (kinetics of substitution of chloride in platinum hydroxyphenylethylenediamine complex by); 138258-84-1P; 142760-37-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and crystal structure leukemia inhibitor activity and kinetics of substitution of chloride in, by iodide)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Projects:SFB 234
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Keywords:Crystal structure Molecular structure (of platinum hydroxyphenylethylenediamine diastereomeric complexes) Substitution reaction (of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Kinetics of substitution reaction (coordinative, of platinum hydroxyphenylethylenediamine diastereomeric complexes with iodide) Isomerism and Isomers (diastereo-, of platinum hydroxyphenylethylenediamine complexes) Neoplasm inhibitors (leukemia, platinum hydroxyphenylethylenediamine diastereomeric complexes as) crystal structure platinum hydroxyphenylethylenediamine complex leukemia inhibitor platinum hydroxyphenylethylenediamine complex kinetics substitution halo platinum hydroxyphenylethylenediamine complex platinum hydroxyphenylethylenediamine structure substitution kinetics
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17701
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