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Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class

Beck, D. ; Fink, K. ; Hoelzl, J. ; Krieglstein, J. ; Petter, A. ; Rieger, H. ; Schönenberger, Helmut


Ten title compds., PhCH2CH(NH2)CONR3CHR2CHR1Ph (R1 = H or OH; R2 and R3 = H or Me), were screened for antidepressant activity. The most active deriv. was N-L-phenylalanyl L-2-amino-1-phenylpropane (I) [85562-33-0]. I exhibited adrenergic activity (noradrenaline potentiation in the rat vas deferens, tetrabenozine antagonism in the mouse), cholinergic blocking activity (acetylcholine antagonism in ...


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