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Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class

Beck, D., Fink, K., Hoelzl, J., Krieglstein, J., Petter, A., Rieger, H. and Schönenberger, Helmut (1983) Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta -phenylalkylamine class. Arzneimittel-Forschung = Drug research 33 (3), pp. 404-410.

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Ten title compds., PhCH2CH(NH2)CONR3CHR2CHR1Ph (R1 = H or OH; R2 and R3 = H or Me), were screened for antidepressant activity. The most active deriv. was N-L-phenylalanyl L-2-amino-1-phenylpropane (I) [85562-33-0]. I exhibited adrenergic activity (noradrenaline potentiation in the rat vas deferens, tetrabenozine antagonism in the mouse), cholinergic blocking activity (acetylcholine antagonism in ...


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Item type:Article
Additional Information (public):CAN 98:172581 1-3 Pharmacology 35402-94-9; 35402-94-9D; 61925-91-5; 61925-92-6; 61925-93-7; 61925-94-8; 61925-95-9; 61950-61-6; 61950-62-7; 61950-63-8; 61950-64-9 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antidepressant activity of, structure in relation to)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Antidepressants (phenylalanylphenylalkylamine derivs. as, structure in relation to) Molecular structure-biological activity relationship (antidepressant, of phenylalanylphenylalkylamines) phenylalanylphenylalkylamine deriv antidepressant structure
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18111
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