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Constitution and pharmacological activity of N-aminoacylephedrines, a new class of local anesthetics

Schönenberger, Helmut ; Brinkmann, R. ; Bamann, E.



Abstract

Reaction of ephedrine or amphetamine with mixed anhydrides of dialkylamino acids and carboxylic acid half esters yields a novel series of acyl derivs. which have local anesthetic activity. Their mechanism of activity is discussed. The acyl derivs. synthesized [Arch. Pharm. 296(1), 33-7(1963)], e.g. N-(DL-N-dimethylphenylalanyl)-L-y-ephedrine, are sepd. into diastereoisomers by the Craig ...

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