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Correlations between chemical structure and antimycotic activity in isomeric hydroxybenzamides

Schönenberger, Helmut ; Holzheu-Eckardt, Juergen ; Bamann, Eugen ; Mehnert, Brigitte


Among the hydroxybenzamide compds. tested, the halogenated o-, m-, and p-hydroxybenzanilides are of special importance in view of their high degree of activity. The effect is highly dependent on the position of the hydroxyl group and the halogen atoms. Optimal effects against dermatophytes were found in the compd. with the OH group in ortho position and the halogen substituted groups in 3- and ...


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