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Cytostatics. 22. Tumor inhibitory N-[bis(2-chloroethyl)aminomethyl]urethanes

Schönenberger, Helmut ; Schmidt, F. ; Bindl, L.



Abstract

Six title compds. inhibited Yoshida ascites sarcoma in rats. The most active compds., N-[bis(2-chloroethyl)aminomethyl]benzylurethane [58050-46-7] and N-[bis(2-chloroethyl)aminomethyl]phenylurethane [58050-47-8], were curative when given at 60% of the LD50 i.m. distributed over 10 days. The LD50 values of the compds. in rats were 11-55 mg/kg i.m. N,N'-di[bis(2-chloroethyl)aminomethyl]urea ...

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