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Cytostatics. 22. Tumor inhibitory N-[bis(2-chloroethyl)aminomethyl]urethanes

Schönenberger, Helmut, Schmidt, F. and Bindl, L. (1975) Cytostatics. 22. Tumor inhibitory N-[bis(2-chloroethyl)aminomethyl]urethanes. Zeitschrift für Krebsforschung und klinische Onkologie 84 (3), pp. 227-240.

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Six title compds. inhibited Yoshida ascites sarcoma in rats. The most active compds., N-[bis(2-chloroethyl)aminomethyl]benzylurethane [58050-46-7] and N-[bis(2-chloroethyl)aminomethyl]phenylurethane [58050-47-8], were curative when given at 60% of the LD50 i.m. distributed over 10 days. The LD50 values of the compds. in rats were 11-55 mg/kg i.m. N,N'-di[bis(2-chloroethyl)aminomethyl]urea ...


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Item type:Article
Additional Information (public):CAN 84:69431 1-5 Pharmacodynamics 1195149-62-2P; 1195267-67-4P Role: SPN (Synthetic preparation), PRP (Properties), PREP (Preparation) (Cytostatics. 22. Tumor inhibitory N-[bis(2-chloroethyl)aminomethyl]urethanes); 51-79-6; 55-86-7; 5027-16-7; 6781-05-1; 7750-75-6; 7751-31-7; 7751-32-8; 10070-94-7; 58050-49-0 Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (neoplasm inhibition by, bis(chloroethyl)aminomethylurethanes in relation to); 58050-42-3P; 58050-43-4P; 58050-44-5P; 58050-45-6P; 58050-46-7P; 58050-47-8P; 58050-48-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. and neoplasm inhibitory activity of); 543-28-2; 598-55-0; 621-84-1; 622-46-8; 1746-77-6 Role: BIOL (Biological study) (reaction with bis(chloroethyl)aminomethanol); 821-48-7 Role: BIOL (Biological study) (reaction with formaldehyde); 50-00-0 Role: RCT (Reactant), RACT (Reactant or reagent) (with bis(chloroethyl)amine)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
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Keywords:Neoplasm inhibitors (bis(chloroethyl)aminomethylurethanes) chloroethylaminomethylurethane neoplasm inhibitor urethane chloroethylaminomethyl neoplasm inhibitor sarcoma inhibitor chloroethylaminomethylurethane cytostatic chloroethylaminomethylurethane
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:18181
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