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Effect of N-acetyl-L-cysteine on ROS production and cell death caused by HEMA in human primary gingival fibroblasts

Spagnuolo, Gianrico ; D'Antò, Vincenzo ; Cosentino, Claudia ; Schmalz, Gottfried ; Schweikl, Helmut ; Rengo, Sandro
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Date of publication of this fulltext: 05 Aug 2009 13:35


Abstract

Previous investigations have shown that 2-hydroxyethyl methacrylate (HEMA) causes reactive oxygen species (ROS) production, which in turn affects cell survival and cell death. The purpose of this study was to evaluate the effects of the antioxidant N-acetyl-L-cysteine (NAC) on HEMA-induced toxicity in human primary gingival fibroblasts (HGF). HGF were treated with various concentrations of HEMA ...

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