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Click Chemistry Based Method for the Preparation of Maleinimide-Type Thiol-Reactive Labels

Link, Martin, Li, Xiaohua, Kleim, Jana and Wolfbeis, Otto S. (2010) Click Chemistry Based Method for the Preparation of Maleinimide-Type Thiol-Reactive Labels. European Journal of Organic Chemistry 2010 (36), pp. 6922-6927.

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Date of publication of this fulltext: 18 Mar 2011 06:41

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Abstract

Maleinimides are widely used to label proteins and to derivatize thiols. The so-called click reaction was shown to allow the efficient introduction of the maleinimido group into azido-modified fluorophores (benzoxazines) by reacting them with an alkyne-modified maleinimide to yield new thiol-reactive fluorescent labels 5–7. The reaction proceeds under mild experimental conditions and provides a ...

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Item type:Article
Date:12 November 2010
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis)
Identification Number:
ValueType
10.1002/ejoc.201001085DOI
Keywords:Click chemistry; Fluorescent probes; Imaging agents; Proteins; Thiols
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Item ID:19953
Owner only: item control page

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