Link, Martin, Li, Xiaohua, Kleim, Jana and Wolfbeis, Otto S. (2010) Click Chemistry Based Method for the Preparation of Maleinimide-Type Thiol-Reactive Labels. European Journal of Organic Chemistry 2010 (36), pp. 6922-6927.
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Abstract
Maleinimides are widely used to label proteins and to derivatize thiols. The so-called click reaction was shown to allow the efficient introduction of the maleinimido group into azido-modified fluorophores (benzoxazines) by reacting them with an alkyne-modified maleinimide to yield new thiol-reactive fluorescent labels 5–7. The reaction proceeds under mild experimental conditions and provides a ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 12 November 2010 | ||||
| Institutions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) | ||||
| Identification Number: |
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| Keywords: | Click chemistry; Fluorescent probes; Imaging agents; Proteins; Thiols | ||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Unknown | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 19953 |
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