Synthetic incorporation of Nile Blue into DNA using 2′-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker

URN to cite this document:: urn:nbn:de:bvb:355-epub-199858
DOI to cite this document:: 10.5283/epub.19985

Lachmann, Daniel ; Berndl, Sina ; Wolfbeis, Otto S.

; Wagenknecht, Hans-Achim

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Date of publication of this fulltext: 18 Mar 2011 06:55

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Abstract

The Nile Blue chromophore was incorporated into oligonucleotides using "click" chemistry for the postsynthetic modification of oligonucleotides. These were synthesized using DNA building block 3 bearing an alkyne group and reacted with the azide 4. (R)-3-amino-1,2-propanediol was applied as the linker between the phosphodiester bridges. Two sets of DNA duplexes were prepared. One set carried the ...