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Synthetic incorporation of Nile Blue into DNA using 2′-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker

URN to cite this document:
urn:nbn:de:bvb:355-epub-199858
Lachmann, Daniel ; Berndl, Sina ; Wolfbeis, Otto S. ; Wagenknecht, Hans-Achim
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Date of publication of this fulltext: 18 Mar 2011 06:55


Abstract

Open AccessThe Nile Blue chromophore was incorporated into oligonucleotides using “click” chemistry for the postsynthetic modification of oligonucleotides. These were synthesized using DNA building block 3 bearing an alkyne group and reacted with the azide 4. (R)-3-amino-1,2-propanediol was applied as the linker between the phosphodiester bridges. Two sets of DNA duplexes were prepared. One set ...

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