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Induction of a MHC class I-restricted, CD8 positive cytolytic T-cell response by chimeric HIV-1 virus-like particles in vivo: implications on HIV vaccine development

URN to cite this document:
urn:nbn:de:bvb:355-epub-203887
Wagner, Ralf ; Deml, L. ; Schirmbeck, R. ; Reimann, J. ; Wolf, Hans J.
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Date of publication of this fulltext: 06 Apr 2011 07:50


Abstract

New insights into HIV-pathogenesis suggest that the cell mediated immune response might play a crucial role in controlling HIV infection by suppressing HIV-replication in CD4-positive cells by a lymphokine-like soluble factor and by killing HIV-infected cells via classical CTL mediated lysis. This type of a cellular immune response rather than an antibody response seems to be most promising to ...

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