The gag proteins of human immunodeficiency virus type 1: mechanisms of virus assembly and possibilities for interference

URN to cite this document:: urn:nbn:de:bvb:355-epub-203909
DOI to cite this document:: 10.5283/epub.20390

Modrow, Susanne ; Kattenbeck, Bernhard ; von Poblotzki, A. ; Niedrig, M. ; Wagner, R. ; Wolf, Hans J.

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Date of publication of this fulltext: 06 Apr 2011 08:01

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Abstract

Using two different experimental systems we were able to define two distinct regions in the sequence of gag proteins of HIV which function in the assembly of structural components of the virus and particle morphogenesis. Since assembly could be inhibited by addition of synthetic non-toxic peptide compounds, a new group of antiviral agents may be developed. This approach represents a completely ...