Negatively cis-acting elements in the distal part of the promoter of Epstein-Barr virus trans-activator gene BZLF1

URN to cite this document:: urn:nbn:de:bvb:355-epub-203915
DOI to cite this document:: 10.5283/epub.20391

Schwarzmann, F. ; Prang, N. ; Reichelt, B. ; Rinkes, B. ; Haist, S. ; Marschall, M. ; Wolf, Hans J.

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Date of publication of this fulltext: 06 Apr 2011 08:04

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Abstract

Epstein-Barr virus (EBV) replicates in a latent or a lytic way in the infected organism, depending on the type and level of differentiation of the host cell. The switch between latency and lytic replication was previously shown, for Burkitt's lymphoma cell lines, to depend on the viral BZLF1 gene product. Protein-DNA assays were used to identify the cis-acting elements that represent the link ...