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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-203959
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.20395
Zusammenfassung
Mutations of the p53 gene are the most frequently observed genetic changes in human cancers; often leading to an overexpression of the wild-type (wt) p53 protein. Demonstrable T cell reactivity against tumor cells overexpressing wt or mutant p53-derived peptides could support the application of such epitopes in cancer immunotherapies. As the binding of peptide to MHC class I molecules is a ...
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