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Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay

URN to cite this document:
urn:nbn:de:bvb:355-epub-203959
Stuber, G. ; Leder, G. H. ; Storkus, W. T. ; Lotze, M. T. ; Modrow, Susanne ; Székely, L. ; Wolf, Hans J. ; Klein, E. ; Kärre, K. ; Klein, G.
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Date of publication of this fulltext: 06 Apr 2011 07:44


Abstract

Mutations of the p53 gene are the most frequently observed genetic changes in human cancers; often leading to an overexpression of the wild-type (wt) p53 protein. Demonstrable T cell reactivity against tumor cells overexpressing wt or mutant p53-derived peptides could support the application of such epitopes in cancer immunotherapies. As the binding of peptide to MHC class I molecules is a ...

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