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Synthetic efforts towards the total synthesis of furanolactone cembranoids and discovery of antimicrobial and anticancer benzyloxylated congeners

URN to cite this document:
urn:nbn:de:bvb:355-epub-207048
Macabeo, Allan Patrick
Date of publication of this fulltext: 08 May 2012 09:07


Abstract (English)

Within the framework of the study’s interest on bioactive structure synthesis and discovery, chemical explorations have been undertaken to develop methods to synthesize complex, highly oxidized furanolactone cembranoids and antiproliferative benzyloxylated derivatives. Bulk of the study has been centered on synthetic strategies en route to the furanocembranoids bielschowskysin, verrillin and ...

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Translation of the abstract (German)

Hauptinteresse dieser Arbeit war die Synthese und Entdeckung von bioaktiven Strukturen. Chemische Untersuchungen wurden durchgeführt um Methoden zu entwickeln, um komplexe, hoch oxygenierte, Furanolakton Cembranoide und um antiproliverative Benzyloxygenierte Derivate davon herzustellen. Der Großteil dieser Arbeit war auf Synthesestrategien in Richtung der Furancembranoiden Bielschowskysin, ...

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