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Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique

URN to cite this document:
Segerer, Hugo ; van Gelder, W. ; Angenent, F. W. ; van Woerkens, L. J. ; Curstedt, T. ; Obladen, M. ; Lachmann, B.
Date of publication of this fulltext: 10 May 2011 08:36


Surfactant bolus instillation has been reported to cause changes in arterial blood pressure (BP) and cerebral blood flow velocities which may increase the risk of intraventricular haemorrhage. To avoid these effects, slow tracheal infusion was evaluated as a possible alternative method of surfactant administration. Saline lung lavages were performed in 13 anesthetized and artificially ventilated ...


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